Keywords
Staphylococcal Infections
Bacteremia
Blood Culture
Anti-Infective Agents
Bacteremia
Blood Culture
Anti-Infective Agents
How to Cite
1.
Aguiar ALR, Barboza MM de O, Costa A da C, Holanda MSB, Dantas AJ, Costa G de S, Dantas GM, Sousa PCP de. Epidemiological profile of Staphylococcus spp. isolated from hemocultures of interned patients in a tertiary attention hospital of the Ceará public network. Rev Inst Adolfo Lutz [Internet]. 2021 Dec. 30 [cited 2024 Jul. 3];80:1-8,e37275. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/37275
Abstract
Staphylococcus spp. has been highlighted among bloodstream infections (BI), presenting high prevalence, multidrug resistance and considerable lethality. The present study aimed to analyze the prevalence and the susceptibility profile of Staphylococcus spp. isolated from positive blood cultures from a tertiary care public hospital of Ceará, from January 2015 to December 2018. Of the 3292 blood cultures performed during this period, only 15.88% were positive, of which 24.85% were Gram positive cocci. S. aureus represented 1.53% of positive blood cultures, of which 50% were oxacilin resistant. Isolates of coagulase-negative Staphylococcus spp. showed a prevalence of 10.89%, represented by: S. epidermidis (n = 23), S. haemolyticus (n = 17), S. hominis (n = 13), S. saprophyticus (n = 2) and S. warneri (n = 2). Multiresistance occurrence was verified in several of the analyzed isolates, presenting intra and inters species variations. Therefore, our findings improve the understanding of the epidemiology of BI caused by Staphylococcus spp. in the studied institution, as well as its susceptibility profile. Early identification of the infectious agent might aid in the appropriate choice of treatment, increasing the chance of cure and reducing the patient length stay in hospital.
References
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22. Sousa MA, Medeiros NM, Carneiro JR, Cardoso AM. Hemoculturas positivas de pacientes da unidade de terapia intensiva de um hospital escola de Goiânia-GO, entre 2010 e 2013. Rev EVS. 2014;41(3):627-35. http://dx.doi.org/10.18224/est.v41i3.3612
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24. Szemraj M, Czekaj T, Kalisz J, Szewczyk EM. Differences in distribution of MLS antibiotics resistance genes in clinical isolates of staphylococci belonging to species: S. epidermidis, S. hominis, S. haemolyticus, S. simulans and S. warneri. BMC Microbiol. 2019;19(1):124. https://doi.org/10.1186 / s12866-019-1496-5
2. World Health Organization. Report on the burden of endemic health care-associated infection worldwide; 2011. Disponível em: https://apps.who.int/iris/handle/10665/80135
3. Azambuja EP, Pires PP, Vaz MRC. Prevenção e controle da infecção hospitalar: as interfaces com o processo de formação do trabalhador. Texto Contexto Enferm. 2004;13(n. esp):79–85. https://doi.org/10.1590/S0104-07072004000500009
4. Butler-Laporte G, De L’Étoile-Morel S, Cheng MP, McDonald EG, Lee TC. MRSA colonization status as a predictor of clinical infection: A systematic review and meta-analysis. J Infect. 2018;77(6):489–95. https://doi.org/10.1016/j.jinf.2018.08.004
5. Araujo MRE. Hemocultura: recomendações de coleta, processamento e interpretação dos resultados. J Infect Control. 2012;1(1):8–19. Disponível em: https://jic-abih.com.br/index.php/jic/article/view/12/11
6. Fernandes DD, Ramos LR, Oliveira MV, Souza CL. Hemocultura em Unidade de Terapia Intensiva: prevalência, perfil de solicitações e susceptibilidade microbiana em um hospital do Sudoeste da Bahia. Rev Bras Pesq Saúde. 2018;20(3):85–94. Disponível em: https://periodicos.ufes.br/rbps/article/view/24506/16705
7. Almeida NR, de Carvalho BMDF, do Nascimento Neta AB, da Páscoa Queiroz S. Perfil epidemiológico das infecções relacionadas à assistência à saúde em Unidades de Terapia Intensiva. Cadernos ESP. 2015;9(1):42–51. Disponível em: https://cadernos.esp.ce.gov.br/index.php/cadernos/article/view/92
8. Zurita J, Mejía C, Guzmán-Blanco M. Diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus in Latin America. Braz J Infect Dis. 2010;14(Suppl 2):S97-106. https://doi.org/10.1590/S1413-86702010000800005
9. Van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL, Gosbell IB. Predictors of mortality in Staphylococcus aureus bacteremia. Clin Microbiol Rev. 2012;25(2):362–86. https://doi.org/10.1128/cmr.05022-11
10. Thorlacius-Ussing L, Sandholdt H, Larsen AR, Petersen A, Benfield T. Age-dependent increase in incidence of Staphylococcus aureus bacteremia, Denmark, 2008–2015. Emerg Infect Dis. 2019;25(5):875-82. https://dx.doi.org/10.3201/eid2505.181773
11. Bastos ECB, Costa ANB, Sousa PDL, Moreira NS, Sousa MVA, Aragão BP, et al. Prevalência de microrganismos isolados de hemoculturas em uma UTI adulto de um hospital de ensino no interior do CEARÁ. Braz J Develop, Curitiba. 2020; 6(8): 59043-47. https://doi.org/10.34117/bjdv6n8-353
12. Naue CR, Ribeiro T, Ribeiro R, Batista K, Aquino S. Ocorrência e perfil bacteriano de culturas coletadas em pacientes internados na unidade de terapia intensiva em um hospital terciário. HU Rev. 2019;45(2):122-33. https://doi.org/10.34019/1982-8047.2019.v45.25933
13. Pedroso SHSP, Sandes SHC, Filho RAT, Nunes AC, Serufo JC, Farias LM et al. Coagulase-negative staphylococci isolated from human bloodstream infections showed multidrug resistance profile. Microb Drug Resist. 2018;24(5):635–47. https://doi.org/10.1089 / mdr.2017.0309
14. Clinical Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically—Eleventh Edition: M07-Ed11. CLSI Wayne, PA, USA; 2018.
15. Libertin CR, Sacco KA, Peterson JH. Education and coaching to optimise blood culture volumes: continuous quality improvement in microbiology. BMJ Open Qual. 2018;7(3):e000228. https://doi.org/10.1136 / bmjoq-2017-000228
16. Sydnor ER, Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011;24(1):141–73. https://doi.org/10.1128/CMR.00027-10
17. Ruschel DB, Rodrigues AD, Formolo F. Perfil de resultados de hemoculturas positivas e fatores associados. RBAC. 2017;49(2):158–63. https://doi.org/10.21877/2448-3877.201600503
18. Dallacorte TS, Indras DM, Teixeira JJV, Peder LD, Silva CM. Prevalência e perfil de sensibilidade antimicrobiana de bactérias isoladas de hemoculturas realizadas em hospitais particulares. Rev Inst Adolfo Lutz. 2016;75:1-11. Disponível em: https://periodicos.saude.sp.gov.br/index.php/RIAL/article/view/33515
19. Oliveira WV, Santos WS, Gomes BS, Costa Lima JL. Etiologia e perfil de susceptibilidade dos microrganismos isolados de hemoculturas no Hospital das Clínicas da UFPE no período de janeiro a dezembro de 2014. RBAC. 2019;51(1):40–5. https://doi.org/10.21877/2448-3877.201900755
20. Alves LNS, Oliveira CR, Silva LAP, Gervásio SMD, Alves SR, Sgavioli GM. Hemoculturas: estudo da prevalência dos microrganismos e o perfil de sensibilidade dos antibióticos utilizados em Unidade de Terapia Intensiva. J Health Sci Inst. 2012;30(1):44–7. Disponível em: https://repositorio.unip.br/wp-content/uploads/2020/12/V30_n1_2011_p44-47.pdf
21. Luna CM, Rodríguez-Noriega E, Bavestrello L, Gotuzzo E. Treatment of methicillin-resistant Staphylococcus aureus in Latin America. Braz J Infect Dis. 2010;14(Suppl 2):S119–27. https://doi.org/10.1590/S1413-86702010000800007
22. Sousa MA, Medeiros NM, Carneiro JR, Cardoso AM. Hemoculturas positivas de pacientes da unidade de terapia intensiva de um hospital escola de Goiânia-GO, entre 2010 e 2013. Rev EVS. 2014;41(3):627-35. http://dx.doi.org/10.18224/est.v41i3.3612
23. Candel FJ, Baos E, Nieto M, Picazo JJ. Could ceftaroline be an alternative therapy for linezolid resistant Staphylococcus epidermidis infections in Intensive Care Medicine? Rev Esp Quimioter. 2015;28(4):214–6. Disponível em: http://www.seq.es/seq/0214-3429/28/4/completo.pdf
24. Szemraj M, Czekaj T, Kalisz J, Szewczyk EM. Differences in distribution of MLS antibiotics resistance genes in clinical isolates of staphylococci belonging to species: S. epidermidis, S. hominis, S. haemolyticus, S. simulans and S. warneri. BMC Microbiol. 2019;19(1):124. https://doi.org/10.1186 / s12866-019-1496-5
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