Palavras-chave
hanseníase
polimorfismo de um único nucleotídeo
susceptibilidade genética
polimorfismo de um único nucleotídeo
susceptibilidade genética
Como Citar
1.
Souza VNB de, Pereira AC. Genética humana na susceptibilidade à hanseníase. Hansen. Int. [Internet]. 30º de junho de 2007 [citado 7º de novembro de 2024];32(1):81-93. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199
Resumo
Dados de investigações familiares, de estudos com gêmeos e da genômica do Mycobacterium leprae, bem como observações sobre a epidemiologia da hanseníase, têm apontado a importância da genética humana como determinante do curso da doença desde a resistência à dicotomia imunológica que definem os pólos tuberculóide e virchowiano. Nesse contexto, estudos de varredura genômica e de associação têm apontado algumas regiões genômicas cujas variações são candidatas a fatores de risco para a doença. Entretanto, as associações já descritas são discretas e não se replicam em todos os estudos, o que evidencia a distinção entre os fatores de risco para diferentes populações, além de divergências nos desenhos destes estudos, como causadores destas controvérsias. Assim, esta revisão tem o propósito de compilação dos dados já descritos para as diversas regiões genômicas humanas que devem participar do controle genético da hanseníase.
Referências
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2 Beiguelman, B. Some remarks on the genetics of leprosy resistance. Acta Genet Med Gemellol 1968;17: 584-594.
3 Ávila JL, Convit J. Studies on cellular immunity in leprosy. I Lysossomal enzymes. Int J Leprosy 1970;38(4): 359-64.
4 Modlin RL. Th1-Th2 paradigm: Insights from Leprosy. J Invest Dermatol 1994; 102(6): 828-32.
5 Foss NT. Aspectos Imunológicos da hanseníase. In: Simpósio: Hanseníase. Medicina Ribeirão Preto 1997; 30: 335-9.
6 Goulart IMB, Penha GO, Cunha G. Imunopatologia da hanseníase: a complexidade dos mecanismos da resposta imune do hospedeiro ao Mycobacterium leprae. Rev Soc Bras Méd Trop 2002; 35(4): 365-375.
7 Convit J, Pinardi ME, Rojas FA. Some considerations regardings the immunology of leprosy. Int J Leprosy 1971; 39(2):556-64.
8 Rea TH, Quismorio FP, Harding B et al. Immunologic responses in pacients with lepromatous leprosy. Arch Dermatol 1976; 112(6): 791-800.
9 Nogueira MES, Vilani-Moreno FR, Silva EA et al. Imunologia. In: Noções de Hansenologia. 2ed. Bauru, 2000.
10 Cole ST, Eiglmeier K, Parkhill J et al. Massive gene decay in the leprosy bacillus. Nature 2001; 409(6823): 1007-11.
11 Monot M, Honore N, Garnier T et al. On the origin of leprosy. Science 2005; 308(5724): 1040-2.
12 Blackwell JM, Black GF, Peacock CS et al. Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study. Philos Trans R Soc Lond B Biol Sci 1997; 352(1359): 1331-45.
13 Blackwell JM. Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil. Int J Parasitol 1998; 28(1): 21-8.
14 Mira MT, Alcais A, Van Thuc N et al. Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. Nat Genet 2003; 33(3): 412-5.
15 Shaw MA, Donaldson IJ, Collins A et al. Associat i o n a n d l i n k a g e o f l e p ro s y p h e n ot y p e s w i t h HL A class II and tumour necrosis fac tor genes. Genes Immun 2001; 2(4): 196-204.
16 Miller EN, Jamieson SE, Joberty C et al. Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. Genes Immun 2004; 5(1):63-7.
17 Todd JR, West BC, McDonald JC. Human leukocyte antigen and leprosy: study in northern Louisiana and review. Rev Infect Dis 1990; 12(1): 63-74.
18 Hegazy AA, Abdel-Hamid IA, Ahmed SF et al. Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors. Int J Dermatol 2002; 41(10): 681-686.
19 Izumi S, Sugiyama K, Matsumoto Y et al. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Vox Sang 1982; 42(5): 243-7.
20 Wang LM, Kimura A, Satoh M et al. HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy. Int J Lepr Other Mycobact Dis 1999; 67(4): 403-8.
21 van Eden W, de Vries RR, Mehra NK et al. HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker. J Infect Dis 1980; 141(6): 693-701.
22 van Eden W, Gonzalez NM, Vries RR et al. HLA-linked control of predisposition to lepromatous leprosy. J Infect Dis 1985; 151(1): 9-14.
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