Keywords
leprosy
single nucleotide polymorphism
genetic susceptibility
single nucleotide polymorphism
genetic susceptibility
How to Cite
1.
Souza VNB de, Pereira AC. Human genetic in leprosy susceptibility. Hansen. Int. [Internet]. 2007 Jun. 30 [cited 2024 Nov. 22];32(1):81-93. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35199
Abstract
Data from familiar investigations, studies involving twins and from Mycobacterium leprae genomic, as well epidemiological observations of leprosy have shown the importance of the human genetic as determinant of the disease’s course, from the resistance, to the immunological dichotomy which defines tuberculoid and lepromatous poles. Thus, studies using genome-wide scan and association methods have shown some genomic regions whose alterations are candidates to risk factors for leprosy. However, these associations are weak and are not repeated in all different studies, which put in evidence the divergence in risk factors for different populations as well in design studies as causatives of this controversial data. In this manner, this review has as purpose the data collection which have already been described about human genomic regions that must participate in the genetic control of leprosy
References
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3 Ávila JL, Convit J. Studies on cellular immunity in leprosy. I Lysossomal enzymes. Int J Leprosy 1970;38(4): 359-64.
4 Modlin RL. Th1-Th2 paradigm: Insights from Leprosy. J Invest Dermatol 1994; 102(6): 828-32.
5 Foss NT. Aspectos Imunológicos da hanseníase. In: Simpósio: Hanseníase. Medicina Ribeirão Preto 1997; 30: 335-9.
6 Goulart IMB, Penha GO, Cunha G. Imunopatologia da hanseníase: a complexidade dos mecanismos da resposta imune do hospedeiro ao Mycobacterium leprae. Rev Soc Bras Méd Trop 2002; 35(4): 365-375.
7 Convit J, Pinardi ME, Rojas FA. Some considerations regardings the immunology of leprosy. Int J Leprosy 1971; 39(2):556-64.
8 Rea TH, Quismorio FP, Harding B et al. Immunologic responses in pacients with lepromatous leprosy. Arch Dermatol 1976; 112(6): 791-800.
9 Nogueira MES, Vilani-Moreno FR, Silva EA et al. Imunologia. In: Noções de Hansenologia. 2ed. Bauru, 2000.
10 Cole ST, Eiglmeier K, Parkhill J et al. Massive gene decay in the leprosy bacillus. Nature 2001; 409(6823): 1007-11.
11 Monot M, Honore N, Garnier T et al. On the origin of leprosy. Science 2005; 308(5724): 1040-2.
12 Blackwell JM, Black GF, Peacock CS et al. Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study. Philos Trans R Soc Lond B Biol Sci 1997; 352(1359): 1331-45.
13 Blackwell JM. Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil. Int J Parasitol 1998; 28(1): 21-8.
14 Mira MT, Alcais A, Van Thuc N et al. Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. Nat Genet 2003; 33(3): 412-5.
15 Shaw MA, Donaldson IJ, Collins A et al. Associat i o n a n d l i n k a g e o f l e p ro s y p h e n ot y p e s w i t h HL A class II and tumour necrosis fac tor genes. Genes Immun 2001; 2(4): 196-204.
16 Miller EN, Jamieson SE, Joberty C et al. Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. Genes Immun 2004; 5(1):63-7.
17 Todd JR, West BC, McDonald JC. Human leukocyte antigen and leprosy: study in northern Louisiana and review. Rev Infect Dis 1990; 12(1): 63-74.
18 Hegazy AA, Abdel-Hamid IA, Ahmed SF et al. Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors. Int J Dermatol 2002; 41(10): 681-686.
19 Izumi S, Sugiyama K, Matsumoto Y et al. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Vox Sang 1982; 42(5): 243-7.
20 Wang LM, Kimura A, Satoh M et al. HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy. Int J Lepr Other Mycobact Dis 1999; 67(4): 403-8.
21 van Eden W, de Vries RR, Mehra NK et al. HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker. J Infect Dis 1980; 141(6): 693-701.
22 van Eden W, Gonzalez NM, Vries RR et al. HLA-linked control of predisposition to lepromatous leprosy. J Infect Dis 1985; 151(1): 9-14.
23 Schauf V, Ryan S, Scollard D et al. Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens 1985; 26(4): 243-7.
24 Visentainer JE, Tsuneto LT, Serra MF et al. Association of leprosy with HLA-DR2 in a Southern Brazilian population. Braz J Med Biol Res 1997; 30(1): 51-9.
25 Rani R, Zaheer SA, Mukherjee R. Do human leukocyte antigens have a role to play in differential manifestation of multibacillary leprosy: a study on multibacillary leprosy patients from north India. Tissue Antigens 1992; 40(3): 124-127.
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