Síndrome de hipersensibilidade à dapsona: revisão sistemática dos critérios diagnósticos
DOI:
https://doi.org/10.47878/hi.2003.v28.35307Palavras-chave:
hanseníase, tratamento, dapsona, síndrome sulfônica, síndrome de hipersensibilidade à dapsonaResumo
A importância mundial da farmacovigilância vem aumentando, mesmo nos países subdesenvolvidos. Neste contexto, a síndrome de hipersensibilidade à dapsona (SHD), um efeito colateral raro e potencialmente grave, deve ser considerada, sem, entretanto, comprometer a segurança da droga e sua ampla utilização. Objetivando padronizar os critérios diagnósticos da síndrome, realizou-se uma revisão sistemática da literatura analisando trabalhos publicados de quinze países endêmicos entre 1956 e 2001. Cento e oito casos foram reportados neste período, destes 96,2% após 1980, com 13,3% de óbitos. Neste grupo, 59% apresentaram a síndrome completa – febre, rash, linfadenomegalia e hepatite, enquanto 41% expressaram forma incompleta. A taxa de mortalidade do grupo que preenche os critérios de SHD completa foi de 9,6% e não houve associação estatística com injúria hepática. Todavia ressalta-se a pouca qualidade dos dados coletados, o que reforça a necessidade de relatos mais precisos em futuras publicações.
Downloads
Não há dados estatísticos.
Referências
1 AGREWALA, J.N. Demonstration of antidapsone antibody in leprosy patient. Int. J. Leprosy, v.57, n.3, p.687-690, 1989.
2 AHMADI, M.A. Dapsone blood dyscrasia in the mouse: evidence for the role of an active metabolite. J. Pharmacol. Pharmacokinetic, v.48, n.2, p.228-232, 1996.
3 ALDDAY, E.J.; BARNES J. Toxic effects of diaminodiphenylsulphone in leprosy. Lancet, ii, p.205-206, 1951.
4 ANDRADE, Z.M.V.; FRANÇA, E.R.; TEIXEIRA, M.A.G.; SANTOS, I.B.S. Síndrome sulfônica: relato de um caso. An. bras. Dermatol., v.74, n.1, p. 59-61, 1999.
5 ARUNTHATHI, S.; JACOB, M.; THERASA, A. The dapsone syndrome. Indian J. Leprosy, v.56, p.206, 1984.
6 BARBOSA, A.M.; MARTINS, E.J.; FLEURY, R.N.; OPROMOLLA, D.V.A. One more case of sulfone syndrome. Hansen. Int., v.25, n.2, p.159-162, 2000.
7 BLETTNER, M.; SAUERBREI, W.; SCHLEHOFER, B.; SCHEUCHENPFLUG, T.; FRIEDENREICH, C. Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int. J. Epidemiol., v.28, p.1-9, 1999.
8 BLULUHM, R.E. Development of dapsone toxicity in patient with inflammatory dermatoses: Activity of acetylation and hydroxylation of dapsone as risk factors. Clin. Pharmacol. Ther., v.65, n.6, p.598-603, 1999.
9 CABRERA, H.N; VALENTE, E.; GALLEGOS, M.C.; GARCIA, S.M. Síndrome de hipersensibilidad a la dapsona. Arch. argent. Dermat., v.47, n.6, p.255-258, 1997.
10 CHAN, H.; LEE, K. Tonsillar membrane in the DDS(dapsone) syndrome. Int. J. Dermatol., v.30, n.3, p.216-217, 1991.
11 FREY, H.M.; GERSHON, A.A.; BORKOWSKY, W.; BULLOCK, W.E. Fatal reaction to dapsone during treatment of leprosy. Ann. Intern.
Med., v.94, p.777-779, 1981.
12 GALLO, M.E.N.; NERY, J.A.C.; GARCIA, C.C. Intercorrências pelas drogas utilizadas nos esquemas poliquimioterápicos em hanseníase. Hansen. Int., v.20, n.2, p.46-50, 1995.
13 GOKHALE, N.R.; SULE, R.R.; GHARPURE, M.B. Dapsone syndrome. Ind. J. Dermatol. Venereol. Leprol., v.58, p.376-378, 1992.
14 GUPTA, C.M.; BHATE, R.D.; SINGH, I.P. The dapsone syndrome - a case report. Indian J. Leprosy, v.57, p.193-195, 1985.
15 JAMROZIK, K. Dapsone syndrome occurring in two brothers. Leprosy Rev., v.57, p.57-62, 1986.
16 JOHNSON, D.A.; CATTAU, E.L.; KURITSKY, J.N.; ZIMMERMAN, H.J. Liver involvement in the sulfone syndrome. Arch. Intern. Med.,
v.145, p.875-877, 1986.
17 JOSEPH, M.S. Hypersensitivity reaction to dapsone. Four case reports. Leprosy Rev., v.56, p.315-320, 1985.
18 KHARE, A.K.; BANSAL, N.K.; MEENA, H.S. Dapsone syndrome - a case report. Indian J. Leprosy, v.59, n.1, p.106109, 1987.
19 KROMANN, N.P.; VIHELMSEN, R.; STAHL D. The dapsone syndrome. Arch. Dermatol., v.118, p.531-532, 1982.20 KUMAR, R.H.; KUMAR, M.V.; THAPPA, D.M. Dapsone syndrome – a five-year retrospective analysis. Indian J. Leprosy, v.70, n.3, p.271-276, 1998.
21 LEIKER, D.L. The mononucleosis syndrome in leprosy patients treated with sulfone. Int. J. Leprosy, v.24, p.402-405, 1956.
22 LOWE, J. Treatment of leprosy with diamino diphenylsulphone. Lancet, p.145-150, 1950.
23 MILLIAM, M. Role of lipid Peroxidation in dapsone -induced Hemolytic Anemia. J. Pharm. Exp. Ther., v.287, p.868-876, 1988.
24 MOHAMED, K.N. Hypersensitivity reaction to dapsone: report from Malaysia. Leprosy Rev., v.55, p.385-389, 1984.
25 NARASIMHA, P.; LAKSHMI, T.S.S. Increase in incidence of dapsone hypersensitivity syndrome – an appraisal. Leprosy Rev., v.72, p. 57-62, 2001.
26 OPROMOLLA, V.A.; FLEURY, R.N. Síndrome da sulfona e reação reversa. Hansen. Int., v.19, n.2, p.70-76, 1994.
27 POTTER, B.; SYZYMANSKI, F.J.; FRETZIN, D. Erythema elevatum diutinum and sulfone hypersensitivity. Arch. Dermatol., v.95, p.436-440, 1967.
28 PAVITHRAN, K. Dapsone syndrome with polyarthritis: a case report. Indian J. Leprosy, v.62, n.2, p.230-232, 1990.
29 PERISSÉ, A.R.S.; GOMES, M.M.; NOGEIRA, S.A. Revisões sistemáticas (inclusive metanálises) e diretrizes clínicas. In: GOMES, M.M. Medicina baseada em evidencias. Damus, p.131-148, 2001.
30 PRUSSICK, R.; SHEAR, N.H. Dapsone hypersensitivity syndrome. J. Amer. Acad. Dermatol., v.35, n.2, p.346-349, 1996.
31 QUEIROZ, R.H. Influence of acetylator phenotype on the haematologycal and biochemical effects associated with dapsone in
leprosy patients. Leprosy Rev., v.68, n.3, p.21-217, 1997.
32 RAMANAN, C.; GHORPADE; MANGLANI, P.R. Dapsone syndrome. Indian J. Leprosy, v.63, n.2, p.226-228, 1991.
33 REEVE, P.A., ALA, J. HALL, J.J. Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. J. Trop. Med. Hyg., v.95, n.4, p.266-270, 1992.
34 REGE, V.L.; SHUKLA, P.; MASCARENHAS, M.F. Dapsone syndrome in Goa. Indian J. Leprosy, v.66, n.1, p.59-64, 1994. 84 Hansenologia Internationalis
35 RICHARDUS, J.H.; SMITH, T.C. Increased incidence in leprosy of hypersensitivity reactions to dapsone after introduction of multidrug therapy. Leprosy Rev., v.60, p.267-273, 1989.
36 ROSE, P. Adverse reactions to rifampicin and dapsone. Leprosy Rev., v.56, p.171, 1985.
37 SANTOS, M.E.; LETA, G.C.; OLIVEIRA, M.L.W.; GOMES, M.K.; MACEIRA, J. Dapsone hypersensitivity syndrome(DHS): not so rare
to be minimezed in endemic countries. In: INTERNATIONAL LEPROSY CONGRESS, 16, Brazil, 4-9, August, 2002
38 SARDARI, L., GARG, B.R. Sulfone induced exfoliative dermatitis and hepatitis. Leprosy in India, v.52, n.2, p.302-305, 1980.
39 SHARMA, V.K.; KAUR, S.; KUMAR, B.; SINGH, M. Dapsone syndrome in India. Indian J. Leprosy, v.57, p.8, 1985.
40 SMITH, W.C.S. Hypersensitivity reaction to dapsone. Leprosy Rev., v.57, p.179-180, 1986.
41 SMITH, D.A. Speculation on the substrate-structure-activity relationship (SSR) of cytochrome P450 enzimes. Biochem. Pharmacol., v.44, p.2089-2098, 1992.
42 SMITH, W.C.S. Are hypersensitivity reactions to dapsone becoming more frequent? Leprosy Rev., v.59, p.53-58, 1988.
43 TOMECKI, K. J.; CATALANO C. J. Dapsone hypersensitivity: the sulfone sydrome revisited. Arch Dermatol,. v.117, n.1, p.38-39, 1981.
44 TROUB, B.V.W.; STUN, R.S. Cutaneous drug reactions. In: FAUCI, A.S. Harrison’s principles of internal medicine. 14ed. McGraw-Hill, 1998. p.304-310
45 WILLE, C.R.; MORROW, J.D. Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider. Am. J. Med. Sci., v.296, n.4, p.270-271, 1988.
46 WOZELL, G. Hypersensitivity to dapsone - an epidemiomological review. In: INTERNATIONAL LEPROSY CONGRESS, 15, Beijing
1998. Abstracts.
47 Homepage institucional da biblioteca de Cochrane - ano 2000. Disponível em: http://www.cochranelibrary.com acesso em
30/07/2002
2 AHMADI, M.A. Dapsone blood dyscrasia in the mouse: evidence for the role of an active metabolite. J. Pharmacol. Pharmacokinetic, v.48, n.2, p.228-232, 1996.
3 ALDDAY, E.J.; BARNES J. Toxic effects of diaminodiphenylsulphone in leprosy. Lancet, ii, p.205-206, 1951.
4 ANDRADE, Z.M.V.; FRANÇA, E.R.; TEIXEIRA, M.A.G.; SANTOS, I.B.S. Síndrome sulfônica: relato de um caso. An. bras. Dermatol., v.74, n.1, p. 59-61, 1999.
5 ARUNTHATHI, S.; JACOB, M.; THERASA, A. The dapsone syndrome. Indian J. Leprosy, v.56, p.206, 1984.
6 BARBOSA, A.M.; MARTINS, E.J.; FLEURY, R.N.; OPROMOLLA, D.V.A. One more case of sulfone syndrome. Hansen. Int., v.25, n.2, p.159-162, 2000.
7 BLETTNER, M.; SAUERBREI, W.; SCHLEHOFER, B.; SCHEUCHENPFLUG, T.; FRIEDENREICH, C. Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int. J. Epidemiol., v.28, p.1-9, 1999.
8 BLULUHM, R.E. Development of dapsone toxicity in patient with inflammatory dermatoses: Activity of acetylation and hydroxylation of dapsone as risk factors. Clin. Pharmacol. Ther., v.65, n.6, p.598-603, 1999.
9 CABRERA, H.N; VALENTE, E.; GALLEGOS, M.C.; GARCIA, S.M. Síndrome de hipersensibilidad a la dapsona. Arch. argent. Dermat., v.47, n.6, p.255-258, 1997.
10 CHAN, H.; LEE, K. Tonsillar membrane in the DDS(dapsone) syndrome. Int. J. Dermatol., v.30, n.3, p.216-217, 1991.
11 FREY, H.M.; GERSHON, A.A.; BORKOWSKY, W.; BULLOCK, W.E. Fatal reaction to dapsone during treatment of leprosy. Ann. Intern.
Med., v.94, p.777-779, 1981.
12 GALLO, M.E.N.; NERY, J.A.C.; GARCIA, C.C. Intercorrências pelas drogas utilizadas nos esquemas poliquimioterápicos em hanseníase. Hansen. Int., v.20, n.2, p.46-50, 1995.
13 GOKHALE, N.R.; SULE, R.R.; GHARPURE, M.B. Dapsone syndrome. Ind. J. Dermatol. Venereol. Leprol., v.58, p.376-378, 1992.
14 GUPTA, C.M.; BHATE, R.D.; SINGH, I.P. The dapsone syndrome - a case report. Indian J. Leprosy, v.57, p.193-195, 1985.
15 JAMROZIK, K. Dapsone syndrome occurring in two brothers. Leprosy Rev., v.57, p.57-62, 1986.
16 JOHNSON, D.A.; CATTAU, E.L.; KURITSKY, J.N.; ZIMMERMAN, H.J. Liver involvement in the sulfone syndrome. Arch. Intern. Med.,
v.145, p.875-877, 1986.
17 JOSEPH, M.S. Hypersensitivity reaction to dapsone. Four case reports. Leprosy Rev., v.56, p.315-320, 1985.
18 KHARE, A.K.; BANSAL, N.K.; MEENA, H.S. Dapsone syndrome - a case report. Indian J. Leprosy, v.59, n.1, p.106109, 1987.
19 KROMANN, N.P.; VIHELMSEN, R.; STAHL D. The dapsone syndrome. Arch. Dermatol., v.118, p.531-532, 1982.20 KUMAR, R.H.; KUMAR, M.V.; THAPPA, D.M. Dapsone syndrome – a five-year retrospective analysis. Indian J. Leprosy, v.70, n.3, p.271-276, 1998.
21 LEIKER, D.L. The mononucleosis syndrome in leprosy patients treated with sulfone. Int. J. Leprosy, v.24, p.402-405, 1956.
22 LOWE, J. Treatment of leprosy with diamino diphenylsulphone. Lancet, p.145-150, 1950.
23 MILLIAM, M. Role of lipid Peroxidation in dapsone -induced Hemolytic Anemia. J. Pharm. Exp. Ther., v.287, p.868-876, 1988.
24 MOHAMED, K.N. Hypersensitivity reaction to dapsone: report from Malaysia. Leprosy Rev., v.55, p.385-389, 1984.
25 NARASIMHA, P.; LAKSHMI, T.S.S. Increase in incidence of dapsone hypersensitivity syndrome – an appraisal. Leprosy Rev., v.72, p. 57-62, 2001.
26 OPROMOLLA, V.A.; FLEURY, R.N. Síndrome da sulfona e reação reversa. Hansen. Int., v.19, n.2, p.70-76, 1994.
27 POTTER, B.; SYZYMANSKI, F.J.; FRETZIN, D. Erythema elevatum diutinum and sulfone hypersensitivity. Arch. Dermatol., v.95, p.436-440, 1967.
28 PAVITHRAN, K. Dapsone syndrome with polyarthritis: a case report. Indian J. Leprosy, v.62, n.2, p.230-232, 1990.
29 PERISSÉ, A.R.S.; GOMES, M.M.; NOGEIRA, S.A. Revisões sistemáticas (inclusive metanálises) e diretrizes clínicas. In: GOMES, M.M. Medicina baseada em evidencias. Damus, p.131-148, 2001.
30 PRUSSICK, R.; SHEAR, N.H. Dapsone hypersensitivity syndrome. J. Amer. Acad. Dermatol., v.35, n.2, p.346-349, 1996.
31 QUEIROZ, R.H. Influence of acetylator phenotype on the haematologycal and biochemical effects associated with dapsone in
leprosy patients. Leprosy Rev., v.68, n.3, p.21-217, 1997.
32 RAMANAN, C.; GHORPADE; MANGLANI, P.R. Dapsone syndrome. Indian J. Leprosy, v.63, n.2, p.226-228, 1991.
33 REEVE, P.A., ALA, J. HALL, J.J. Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. J. Trop. Med. Hyg., v.95, n.4, p.266-270, 1992.
34 REGE, V.L.; SHUKLA, P.; MASCARENHAS, M.F. Dapsone syndrome in Goa. Indian J. Leprosy, v.66, n.1, p.59-64, 1994. 84 Hansenologia Internationalis
35 RICHARDUS, J.H.; SMITH, T.C. Increased incidence in leprosy of hypersensitivity reactions to dapsone after introduction of multidrug therapy. Leprosy Rev., v.60, p.267-273, 1989.
36 ROSE, P. Adverse reactions to rifampicin and dapsone. Leprosy Rev., v.56, p.171, 1985.
37 SANTOS, M.E.; LETA, G.C.; OLIVEIRA, M.L.W.; GOMES, M.K.; MACEIRA, J. Dapsone hypersensitivity syndrome(DHS): not so rare
to be minimezed in endemic countries. In: INTERNATIONAL LEPROSY CONGRESS, 16, Brazil, 4-9, August, 2002
38 SARDARI, L., GARG, B.R. Sulfone induced exfoliative dermatitis and hepatitis. Leprosy in India, v.52, n.2, p.302-305, 1980.
39 SHARMA, V.K.; KAUR, S.; KUMAR, B.; SINGH, M. Dapsone syndrome in India. Indian J. Leprosy, v.57, p.8, 1985.
40 SMITH, W.C.S. Hypersensitivity reaction to dapsone. Leprosy Rev., v.57, p.179-180, 1986.
41 SMITH, D.A. Speculation on the substrate-structure-activity relationship (SSR) of cytochrome P450 enzimes. Biochem. Pharmacol., v.44, p.2089-2098, 1992.
42 SMITH, W.C.S. Are hypersensitivity reactions to dapsone becoming more frequent? Leprosy Rev., v.59, p.53-58, 1988.
43 TOMECKI, K. J.; CATALANO C. J. Dapsone hypersensitivity: the sulfone sydrome revisited. Arch Dermatol,. v.117, n.1, p.38-39, 1981.
44 TROUB, B.V.W.; STUN, R.S. Cutaneous drug reactions. In: FAUCI, A.S. Harrison’s principles of internal medicine. 14ed. McGraw-Hill, 1998. p.304-310
45 WILLE, C.R.; MORROW, J.D. Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider. Am. J. Med. Sci., v.296, n.4, p.270-271, 1988.
46 WOZELL, G. Hypersensitivity to dapsone - an epidemiomological review. In: INTERNATIONAL LEPROSY CONGRESS, 15, Beijing
1998. Abstracts.
47 Homepage institucional da biblioteca de Cochrane - ano 2000. Disponível em: http://www.cochranelibrary.com acesso em
30/07/2002
Downloads
Publicado
30-06-2003
Como Citar
1.
Leta GC, Simas MEP de ADS, Oliveira MLW de, Gomes MK. Síndrome de hipersensibilidade à dapsona: revisão sistemática dos critérios diagnósticos. Hansen. Int. [Internet]. 30º de junho de 2003 [citado 26º de abril de 2024];28(1):79-84. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35307
Edição
Seção
Artigos originais
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Este periódico está licenciado sob uma Creative Commons Attribution 4.0 International License.
