Alteración de la inminidad mediada por células frente a Mycobacterium leprae y mycobacterium marinum en pacientes hansenianos
DOI:
https://doi.org/10.47878/hi.1983.v8.35579Palavras-chave:
Inmunidad mediada por células, Mycobacterium leprae, Mycobacterium marinumResumo
Se estudió la inmunidad mediada por células (IMC) frente a derivados proteicos purificados de Mycobacterium leprae, Mycobacterium tuberculosis, Myco- bacterium avium y Mycobacterium marinum. Se efectuaron tests cutineos de hipersensibilidad retardada einhibicién de la migración de leucocitos in vitro en 44 pacientes hansenianos (20 virchowianos quiescentes, 13 virchowianos reaccionales y 11 tuberculoides) y en 15 testigos sanos. Se observóuna alteración de la inhibicifin de la migración de leucocitos y de la hipersensibilidad cutinea frente a M. leprae y M. marinum en los pacientes vircho- wianos, quiescentes y reaccionales. La respuesta de la IMC frente a todos los antigenos micobacterianos se encontró aumentada en los pacientes tuberculoides, y se observó una respuesta débil frente a M. leprae y M. marinum en los controles sanos. Los resultados obtenidos muestran una estrecha correlación entre la IMC frente a M. leprae y M. marinum en todos los casos, la cual podria expresar reactividad cruzada entre ambos antígenos.
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Referências
1 BALIA, L.M.; FLIESS, E.L.; BACH- MANN, A.E.; CARDAMA, J.E.; GATTI, J.C. Similar alterations of lymphoblastic differentiation in
lepromatous leprosy patients and their healthy lepromin-negative consaguineons offspring. Int. J. Lepr., 41(1): 7-13, 1973.
2 BALIA, L.M.; VALDEZ, R.P.; BIAN- CHI, O.; MENDIETA, S.; DIAZ, P.; GARCIA, N. Estudios y adaptación de D. hybridus y Ch. villosus. Leprología, 21(2):14-17, 1979.
3 BEIGUELMAN, B. & PISANI, R.C.B. Effect of DDS on phytohemagglutinin-induced lymphocyte transforma- tion. Int. J. Lepr., 42(4): 412-415, 1974.
4 BENDIXEN, G. & SOBORG, M. Com- ments on the leukocyte migration technique as in vitro method for de- monstrating cellular
hypersensitivity in man. J. Immunol., 104 (6):1551- -1552, 1970.
5 BJUNE, G. In vitro lymphocyte stimulation in leprosy; simultaneous stimulations with Mycobacterium leprae antigens and
phytohemagglutinin. Clin. Exp. Immunol., 37:479-487, 1979.
6 BRAUN, M.; SEN, L.; BACHMAN, A.E.; PAVLOVSKY, A. Cell migration inhibition in human lymphomas using lymph nodes and cell line antigens. Blood, 39:368-376, 1972.
7 CONVIT, J.; ARANZAZU, N.; PINAR- DI, M.; ULRICH, M. Immunological changes observed in indeterminate and lepromatous
leprosy patients and Mitsuda negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp.
Immunol., 36(2) :214-220, 1979.
8 DHARMENDRA Immunological skin tests in leprosy; isolation of protein antigen of Mycobacterium leprae. Indian J. Med. Res., 30:1-7, 1942.
9 DIERKS, R.E. & SHEPARD, C.C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc. Soc. Exp. Biol., 127(2):391-395, 1968.
10 FERNANDEZ, J.M.M. The early reac- tion induced by lepromin. Int. J. Lepr., 8(1):1-14, 1940.
11 FLIESS, EL. Inmunopatologia de la lepra. Tem. Lepr., 20(59):3-32, 1976.
12 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2):141-150, 1978.
13 FLIESS, E.L. & BACHMANN, A.E. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Argent. Mierobiol. 9(1):28-36, 1977.
14 FLIESS, E.L.; BACHMANN, A.E.; CA- ROSELLA, E.D. Exploración de la inmunidad mediada por células en pacientes de lepra. Tem
Lepr., 20 (60) :3-53, 1977.
15 FLIESS, E.L.; RUIBAL-ARES, B.; BRAUN, M. Serum factors affecting the cell migration inhibition response to lepromin. Int. J. Lepr.,
43(4): 320-326, 1975.
16 GARCIA SABATER, J.F.; AMADOR YSCLA, A.; PERALES OBENICH, J.A. Clasificación e identificaei6n del género Mycobacterium. Rev. Lat. Amer. Microbiol., 19(1):7-15, 1977.
17 GEEI, S.K.; SENGUPTA, U.; DESI- KAN, K.V. In vitro effect of DDS on phytohemagglutinin (PHA) — induced lymphocyte transformation. Hansen. Int., 5(2): 112-118, 1980.
18 GOIHMAN-YAHR, M.; RAFFEL, S.; FERRARESI, R.W. Cross reactivities on lepromin. ht. Arch. Allergy Appl. Imunol., 36:450-454, 1969.
19 GODAL, T. Immunological aspects of leprosy. Present status. Prog. Allergy, 25:211-242, 1978.
20 GODAL, T.; MYRVANG, B.; STAN- FORD, J.L.; SAMUEL, D.R. Recent advances in the immunology of lepro- sy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72(3) :273-310, 1974.
21 GOVIL, D.C. & BHUTANI, L.K. Delayed hypersensitivity skin reactions to le- promin and antigens prepared from four other
mycobacteria. Lepr. 50(4):550-554, 1978.
22 HANKS, J.H. & FERNANDEZ, J.M.M. Enhancement of resistance to murine leprosy by BCG plus specific antigen. Int. J. Lepr., 24(1) :65-73, 1956.
23 KIRCHHEIMER, W.F. & STORRS, E.E. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study
of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo. Int J. Lepr., 39(3) :693-702, 1971.
24 MEHRA, V.; MASON, L.H.; ROTHMAN, W.; REINHERZ, E.; SCHLOS- SMAN, S.F.; BLOOM, B.R. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J. Immunol., 125(3) :1183-1188, 1980.
25 MORINI, J.C. & CORONA, C. Lepra y tolerancia inmunologica. Leprologia, 21(2) :71-75, 1979.
26 MUSTAFA, A.S. & TALWAR, G.P. Five cultivable mycobacterial strains giv- ing transformation and leukocyte migration inhibition of
leukocytes analogous to Mycobacterium leprae. Lepr. India., 50(4) :498-508, 1978.
27 MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. Immune responsiveness to Mycobacterium lepro, e
and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553, 1973.
28 NATH, I. & SINGE, R. The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol., 41:406-414, 1980.
29 OPROMOLLA, D.V.A.; ARRUDA, 0.S.; _ FLEURY, R.N. Manutenção de tatus em cativeiro e resultados de inoculação do Mycobacterium leprae. Hansen. Int., 5(1):28-36, 1980.
30 REA, T.H. & LEVAN, N.E. Current concepts in the immunology of leprosy. Arch. Dom., 113:(3) :345-352, 1977.
31 RODRIGUEZ PARADISI, E.; BONA- PARTE, Y.P. de; MORGENFELD, M.G. Cultivo de linfocitos en enfermos con lepra lepromatosa. Leprologia, 12(2):61-63, 1967.
32 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromintested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97, 1937.
33 SHARMA, R.C. & SINGE, R. Comparative study of skin reactions in leprosy patients to M. leprae - lepromin and toantigens from cultivable saprophytic mycobacteria. Lepr. India, 50 (4): 572-578, 1978.
34 SHEPARD, C.C.; VAN LANDINGHAM, R.; WALKER, L.L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect. Immun., 14(4):919-928, 1976.
35 STONER, G.L.; TOUW, J.; ATLAW, T.; BELEHU, A. Antigen-specific suppressor cells in subclinical leprosy infection. Lancet, 2(8260/61):1372- -1377, 1981.
36 WOLINSKY, E. Non-tuberculous mycobacteria and associated diseases. Amer. Rev. Reap. Dig., 119 (1) : 107-159, 1979.
lepromatous leprosy patients and their healthy lepromin-negative consaguineons offspring. Int. J. Lepr., 41(1): 7-13, 1973.
2 BALIA, L.M.; VALDEZ, R.P.; BIAN- CHI, O.; MENDIETA, S.; DIAZ, P.; GARCIA, N. Estudios y adaptación de D. hybridus y Ch. villosus. Leprología, 21(2):14-17, 1979.
3 BEIGUELMAN, B. & PISANI, R.C.B. Effect of DDS on phytohemagglutinin-induced lymphocyte transforma- tion. Int. J. Lepr., 42(4): 412-415, 1974.
4 BENDIXEN, G. & SOBORG, M. Com- ments on the leukocyte migration technique as in vitro method for de- monstrating cellular
hypersensitivity in man. J. Immunol., 104 (6):1551- -1552, 1970.
5 BJUNE, G. In vitro lymphocyte stimulation in leprosy; simultaneous stimulations with Mycobacterium leprae antigens and
phytohemagglutinin. Clin. Exp. Immunol., 37:479-487, 1979.
6 BRAUN, M.; SEN, L.; BACHMAN, A.E.; PAVLOVSKY, A. Cell migration inhibition in human lymphomas using lymph nodes and cell line antigens. Blood, 39:368-376, 1972.
7 CONVIT, J.; ARANZAZU, N.; PINAR- DI, M.; ULRICH, M. Immunological changes observed in indeterminate and lepromatous
leprosy patients and Mitsuda negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp.
Immunol., 36(2) :214-220, 1979.
8 DHARMENDRA Immunological skin tests in leprosy; isolation of protein antigen of Mycobacterium leprae. Indian J. Med. Res., 30:1-7, 1942.
9 DIERKS, R.E. & SHEPARD, C.C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc. Soc. Exp. Biol., 127(2):391-395, 1968.
10 FERNANDEZ, J.M.M. The early reac- tion induced by lepromin. Int. J. Lepr., 8(1):1-14, 1940.
11 FLIESS, EL. Inmunopatologia de la lepra. Tem. Lepr., 20(59):3-32, 1976.
12 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2):141-150, 1978.
13 FLIESS, E.L. & BACHMANN, A.E. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Argent. Mierobiol. 9(1):28-36, 1977.
14 FLIESS, E.L.; BACHMANN, A.E.; CA- ROSELLA, E.D. Exploración de la inmunidad mediada por células en pacientes de lepra. Tem
Lepr., 20 (60) :3-53, 1977.
15 FLIESS, E.L.; RUIBAL-ARES, B.; BRAUN, M. Serum factors affecting the cell migration inhibition response to lepromin. Int. J. Lepr.,
43(4): 320-326, 1975.
16 GARCIA SABATER, J.F.; AMADOR YSCLA, A.; PERALES OBENICH, J.A. Clasificación e identificaei6n del género Mycobacterium. Rev. Lat. Amer. Microbiol., 19(1):7-15, 1977.
17 GEEI, S.K.; SENGUPTA, U.; DESI- KAN, K.V. In vitro effect of DDS on phytohemagglutinin (PHA) — induced lymphocyte transformation. Hansen. Int., 5(2): 112-118, 1980.
18 GOIHMAN-YAHR, M.; RAFFEL, S.; FERRARESI, R.W. Cross reactivities on lepromin. ht. Arch. Allergy Appl. Imunol., 36:450-454, 1969.
19 GODAL, T. Immunological aspects of leprosy. Present status. Prog. Allergy, 25:211-242, 1978.
20 GODAL, T.; MYRVANG, B.; STAN- FORD, J.L.; SAMUEL, D.R. Recent advances in the immunology of lepro- sy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72(3) :273-310, 1974.
21 GOVIL, D.C. & BHUTANI, L.K. Delayed hypersensitivity skin reactions to le- promin and antigens prepared from four other
mycobacteria. Lepr. 50(4):550-554, 1978.
22 HANKS, J.H. & FERNANDEZ, J.M.M. Enhancement of resistance to murine leprosy by BCG plus specific antigen. Int. J. Lepr., 24(1) :65-73, 1956.
23 KIRCHHEIMER, W.F. & STORRS, E.E. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study
of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo. Int J. Lepr., 39(3) :693-702, 1971.
24 MEHRA, V.; MASON, L.H.; ROTHMAN, W.; REINHERZ, E.; SCHLOS- SMAN, S.F.; BLOOM, B.R. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J. Immunol., 125(3) :1183-1188, 1980.
25 MORINI, J.C. & CORONA, C. Lepra y tolerancia inmunologica. Leprologia, 21(2) :71-75, 1979.
26 MUSTAFA, A.S. & TALWAR, G.P. Five cultivable mycobacterial strains giv- ing transformation and leukocyte migration inhibition of
leukocytes analogous to Mycobacterium leprae. Lepr. India., 50(4) :498-508, 1978.
27 MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. Immune responsiveness to Mycobacterium lepro, e
and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553, 1973.
28 NATH, I. & SINGE, R. The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol., 41:406-414, 1980.
29 OPROMOLLA, D.V.A.; ARRUDA, 0.S.; _ FLEURY, R.N. Manutenção de tatus em cativeiro e resultados de inoculação do Mycobacterium leprae. Hansen. Int., 5(1):28-36, 1980.
30 REA, T.H. & LEVAN, N.E. Current concepts in the immunology of leprosy. Arch. Dom., 113:(3) :345-352, 1977.
31 RODRIGUEZ PARADISI, E.; BONA- PARTE, Y.P. de; MORGENFELD, M.G. Cultivo de linfocitos en enfermos con lepra lepromatosa. Leprologia, 12(2):61-63, 1967.
32 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromintested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97, 1937.
33 SHARMA, R.C. & SINGE, R. Comparative study of skin reactions in leprosy patients to M. leprae - lepromin and toantigens from cultivable saprophytic mycobacteria. Lepr. India, 50 (4): 572-578, 1978.
34 SHEPARD, C.C.; VAN LANDINGHAM, R.; WALKER, L.L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect. Immun., 14(4):919-928, 1976.
35 STONER, G.L.; TOUW, J.; ATLAW, T.; BELEHU, A. Antigen-specific suppressor cells in subclinical leprosy infection. Lancet, 2(8260/61):1372- -1377, 1981.
36 WOLINSKY, E. Non-tuberculous mycobacteria and associated diseases. Amer. Rev. Reap. Dig., 119 (1) : 107-159, 1979.
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30-06-1983
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FLIESS EL, ORTIZ MC, CORN J. Alteración de la inminidad mediada por células frente a Mycobacterium leprae y mycobacterium marinum en pacientes hansenianos. Hansen. Int. [Internet]. 30º de junho de 1983 [citado 6º de maio de 2024];8(1):9-17. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35579
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