Alteración de la inminidad mediada por células frente a Mycobacterium leprae y mycobacterium marinum en pacientes hansenianos
DOI:
https://doi.org/10.47878/hi.1983.v8.35579Keywords:
Cell mediated immunity, Mycobacterium leprae, Mycobacterium marinumAbstract
The cell mediated immunity (CMI) to protein purified derivates of Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium marinum was studied. Leukocyte Migration Inhibition (LMI) and Delayed Hypersensitivy skin reactions to these antigens were examined in 44 hanseniasis patients (20 quiescent Virchowians, 13 reactional Virchowians and 11 tuberculoid patients) and 15 healthy subjects. An impairment in LMI and Delayed Hypersensitivity tests to M. leprae and M. maximum was observed in Virchowians patients both quiescent and reactional. The CMI response to all mycobacterial antigens was increased in tuberculoid patients and was observed a poor response to M. leprae and M. marinum in healthy controls. Our results show a high correlation between the CMI response to M. leprae and to M. marinum (r = + 0,8). This close relationship between both antigens may express.
cross-reactivity.
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References
1 BALIA, L.M.; FLIESS, E.L.; BACH- MANN, A.E.; CARDAMA, J.E.; GATTI, J.C. Similar alterations of lymphoblastic differentiation in
lepromatous leprosy patients and their healthy lepromin-negative consaguineons offspring. Int. J. Lepr., 41(1): 7-13, 1973.
2 BALIA, L.M.; VALDEZ, R.P.; BIAN- CHI, O.; MENDIETA, S.; DIAZ, P.; GARCIA, N. Estudios y adaptación de D. hybridus y Ch. villosus. Leprología, 21(2):14-17, 1979.
3 BEIGUELMAN, B. & PISANI, R.C.B. Effect of DDS on phytohemagglutinin-induced lymphocyte transforma- tion. Int. J. Lepr., 42(4): 412-415, 1974.
4 BENDIXEN, G. & SOBORG, M. Com- ments on the leukocyte migration technique as in vitro method for de- monstrating cellular
hypersensitivity in man. J. Immunol., 104 (6):1551- -1552, 1970.
5 BJUNE, G. In vitro lymphocyte stimulation in leprosy; simultaneous stimulations with Mycobacterium leprae antigens and
phytohemagglutinin. Clin. Exp. Immunol., 37:479-487, 1979.
6 BRAUN, M.; SEN, L.; BACHMAN, A.E.; PAVLOVSKY, A. Cell migration inhibition in human lymphomas using lymph nodes and cell line antigens. Blood, 39:368-376, 1972.
7 CONVIT, J.; ARANZAZU, N.; PINAR- DI, M.; ULRICH, M. Immunological changes observed in indeterminate and lepromatous
leprosy patients and Mitsuda negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp.
Immunol., 36(2) :214-220, 1979.
8 DHARMENDRA Immunological skin tests in leprosy; isolation of protein antigen of Mycobacterium leprae. Indian J. Med. Res., 30:1-7, 1942.
9 DIERKS, R.E. & SHEPARD, C.C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc. Soc. Exp. Biol., 127(2):391-395, 1968.
10 FERNANDEZ, J.M.M. The early reac- tion induced by lepromin. Int. J. Lepr., 8(1):1-14, 1940.
11 FLIESS, EL. Inmunopatologia de la lepra. Tem. Lepr., 20(59):3-32, 1976.
12 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2):141-150, 1978.
13 FLIESS, E.L. & BACHMANN, A.E. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Argent. Mierobiol. 9(1):28-36, 1977.
14 FLIESS, E.L.; BACHMANN, A.E.; CA- ROSELLA, E.D. Exploración de la inmunidad mediada por células en pacientes de lepra. Tem
Lepr., 20 (60) :3-53, 1977.
15 FLIESS, E.L.; RUIBAL-ARES, B.; BRAUN, M. Serum factors affecting the cell migration inhibition response to lepromin. Int. J. Lepr.,
43(4): 320-326, 1975.
16 GARCIA SABATER, J.F.; AMADOR YSCLA, A.; PERALES OBENICH, J.A. Clasificación e identificaei6n del género Mycobacterium. Rev. Lat. Amer. Microbiol., 19(1):7-15, 1977.
17 GEEI, S.K.; SENGUPTA, U.; DESI- KAN, K.V. In vitro effect of DDS on phytohemagglutinin (PHA) — induced lymphocyte transformation. Hansen. Int., 5(2): 112-118, 1980.
18 GOIHMAN-YAHR, M.; RAFFEL, S.; FERRARESI, R.W. Cross reactivities on lepromin. ht. Arch. Allergy Appl. Imunol., 36:450-454, 1969.
19 GODAL, T. Immunological aspects of leprosy. Present status. Prog. Allergy, 25:211-242, 1978.
20 GODAL, T.; MYRVANG, B.; STAN- FORD, J.L.; SAMUEL, D.R. Recent advances in the immunology of lepro- sy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72(3) :273-310, 1974.
21 GOVIL, D.C. & BHUTANI, L.K. Delayed hypersensitivity skin reactions to le- promin and antigens prepared from four other
mycobacteria. Lepr. 50(4):550-554, 1978.
22 HANKS, J.H. & FERNANDEZ, J.M.M. Enhancement of resistance to murine leprosy by BCG plus specific antigen. Int. J. Lepr., 24(1) :65-73, 1956.
23 KIRCHHEIMER, W.F. & STORRS, E.E. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study
of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo. Int J. Lepr., 39(3) :693-702, 1971.
24 MEHRA, V.; MASON, L.H.; ROTHMAN, W.; REINHERZ, E.; SCHLOS- SMAN, S.F.; BLOOM, B.R. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J. Immunol., 125(3) :1183-1188, 1980.
25 MORINI, J.C. & CORONA, C. Lepra y tolerancia inmunologica. Leprologia, 21(2) :71-75, 1979.
26 MUSTAFA, A.S. & TALWAR, G.P. Five cultivable mycobacterial strains giv- ing transformation and leukocyte migration inhibition of
leukocytes analogous to Mycobacterium leprae. Lepr. India., 50(4) :498-508, 1978.
27 MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. Immune responsiveness to Mycobacterium lepro, e
and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553, 1973.
28 NATH, I. & SINGE, R. The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol., 41:406-414, 1980.
29 OPROMOLLA, D.V.A.; ARRUDA, 0.S.; _ FLEURY, R.N. Manutenção de tatus em cativeiro e resultados de inoculação do Mycobacterium leprae. Hansen. Int., 5(1):28-36, 1980.
30 REA, T.H. & LEVAN, N.E. Current concepts in the immunology of leprosy. Arch. Dom., 113:(3) :345-352, 1977.
31 RODRIGUEZ PARADISI, E.; BONA- PARTE, Y.P. de; MORGENFELD, M.G. Cultivo de linfocitos en enfermos con lepra lepromatosa. Leprologia, 12(2):61-63, 1967.
32 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromintested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97, 1937.
33 SHARMA, R.C. & SINGE, R. Comparative study of skin reactions in leprosy patients to M. leprae - lepromin and toantigens from cultivable saprophytic mycobacteria. Lepr. India, 50 (4): 572-578, 1978.
34 SHEPARD, C.C.; VAN LANDINGHAM, R.; WALKER, L.L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect. Immun., 14(4):919-928, 1976.
35 STONER, G.L.; TOUW, J.; ATLAW, T.; BELEHU, A. Antigen-specific suppressor cells in subclinical leprosy infection. Lancet, 2(8260/61):1372- -1377, 1981.
36 WOLINSKY, E. Non-tuberculous mycobacteria and associated diseases. Amer. Rev. Reap. Dig., 119 (1) : 107-159, 1979.
lepromatous leprosy patients and their healthy lepromin-negative consaguineons offspring. Int. J. Lepr., 41(1): 7-13, 1973.
2 BALIA, L.M.; VALDEZ, R.P.; BIAN- CHI, O.; MENDIETA, S.; DIAZ, P.; GARCIA, N. Estudios y adaptación de D. hybridus y Ch. villosus. Leprología, 21(2):14-17, 1979.
3 BEIGUELMAN, B. & PISANI, R.C.B. Effect of DDS on phytohemagglutinin-induced lymphocyte transforma- tion. Int. J. Lepr., 42(4): 412-415, 1974.
4 BENDIXEN, G. & SOBORG, M. Com- ments on the leukocyte migration technique as in vitro method for de- monstrating cellular
hypersensitivity in man. J. Immunol., 104 (6):1551- -1552, 1970.
5 BJUNE, G. In vitro lymphocyte stimulation in leprosy; simultaneous stimulations with Mycobacterium leprae antigens and
phytohemagglutinin. Clin. Exp. Immunol., 37:479-487, 1979.
6 BRAUN, M.; SEN, L.; BACHMAN, A.E.; PAVLOVSKY, A. Cell migration inhibition in human lymphomas using lymph nodes and cell line antigens. Blood, 39:368-376, 1972.
7 CONVIT, J.; ARANZAZU, N.; PINAR- DI, M.; ULRICH, M. Immunological changes observed in indeterminate and lepromatous
leprosy patients and Mitsuda negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp.
Immunol., 36(2) :214-220, 1979.
8 DHARMENDRA Immunological skin tests in leprosy; isolation of protein antigen of Mycobacterium leprae. Indian J. Med. Res., 30:1-7, 1942.
9 DIERKS, R.E. & SHEPARD, C.C. Effect of phytohemagglutinin and various mycobacterial antigens on lymphocyte cultures from leprosy patients. Proc. Soc. Exp. Biol., 127(2):391-395, 1968.
10 FERNANDEZ, J.M.M. The early reac- tion induced by lepromin. Int. J. Lepr., 8(1):1-14, 1940.
11 FLIESS, EL. Inmunopatologia de la lepra. Tem. Lepr., 20(59):3-32, 1976.
12 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2):141-150, 1978.
13 FLIESS, E.L. & BACHMANN, A.E. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Argent. Mierobiol. 9(1):28-36, 1977.
14 FLIESS, E.L.; BACHMANN, A.E.; CA- ROSELLA, E.D. Exploración de la inmunidad mediada por células en pacientes de lepra. Tem
Lepr., 20 (60) :3-53, 1977.
15 FLIESS, E.L.; RUIBAL-ARES, B.; BRAUN, M. Serum factors affecting the cell migration inhibition response to lepromin. Int. J. Lepr.,
43(4): 320-326, 1975.
16 GARCIA SABATER, J.F.; AMADOR YSCLA, A.; PERALES OBENICH, J.A. Clasificación e identificaei6n del género Mycobacterium. Rev. Lat. Amer. Microbiol., 19(1):7-15, 1977.
17 GEEI, S.K.; SENGUPTA, U.; DESI- KAN, K.V. In vitro effect of DDS on phytohemagglutinin (PHA) — induced lymphocyte transformation. Hansen. Int., 5(2): 112-118, 1980.
18 GOIHMAN-YAHR, M.; RAFFEL, S.; FERRARESI, R.W. Cross reactivities on lepromin. ht. Arch. Allergy Appl. Imunol., 36:450-454, 1969.
19 GODAL, T. Immunological aspects of leprosy. Present status. Prog. Allergy, 25:211-242, 1978.
20 GODAL, T.; MYRVANG, B.; STAN- FORD, J.L.; SAMUEL, D.R. Recent advances in the immunology of lepro- sy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72(3) :273-310, 1974.
21 GOVIL, D.C. & BHUTANI, L.K. Delayed hypersensitivity skin reactions to le- promin and antigens prepared from four other
mycobacteria. Lepr. 50(4):550-554, 1978.
22 HANKS, J.H. & FERNANDEZ, J.M.M. Enhancement of resistance to murine leprosy by BCG plus specific antigen. Int. J. Lepr., 24(1) :65-73, 1956.
23 KIRCHHEIMER, W.F. & STORRS, E.E. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study
of leprosy. I. Report of lepromatoid leprosy in an experimentally infected armadillo. Int J. Lepr., 39(3) :693-702, 1971.
24 MEHRA, V.; MASON, L.H.; ROTHMAN, W.; REINHERZ, E.; SCHLOS- SMAN, S.F.; BLOOM, B.R. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J. Immunol., 125(3) :1183-1188, 1980.
25 MORINI, J.C. & CORONA, C. Lepra y tolerancia inmunologica. Leprologia, 21(2) :71-75, 1979.
26 MUSTAFA, A.S. & TALWAR, G.P. Five cultivable mycobacterial strains giv- ing transformation and leukocyte migration inhibition of
leukocytes analogous to Mycobacterium leprae. Lepr. India., 50(4) :498-508, 1978.
27 MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. Immune responsiveness to Mycobacterium lepro, e
and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553, 1973.
28 NATH, I. & SINGE, R. The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin. Exp. Immunol., 41:406-414, 1980.
29 OPROMOLLA, D.V.A.; ARRUDA, 0.S.; _ FLEURY, R.N. Manutenção de tatus em cativeiro e resultados de inoculação do Mycobacterium leprae. Hansen. Int., 5(1):28-36, 1980.
30 REA, T.H. & LEVAN, N.E. Current concepts in the immunology of leprosy. Arch. Dom., 113:(3) :345-352, 1977.
31 RODRIGUEZ PARADISI, E.; BONA- PARTE, Y.P. de; MORGENFELD, M.G. Cultivo de linfocitos en enfermos con lepra lepromatosa. Leprologia, 12(2):61-63, 1967.
32 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromintested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97, 1937.
33 SHARMA, R.C. & SINGE, R. Comparative study of skin reactions in leprosy patients to M. leprae - lepromin and toantigens from cultivable saprophytic mycobacteria. Lepr. India, 50 (4): 572-578, 1978.
34 SHEPARD, C.C.; VAN LANDINGHAM, R.; WALKER, L.L. Immunity to Mycobacterium leprae infections in mice stimulated by M. leprae, BCG, and graft-versus-host reactions. Infect. Immun., 14(4):919-928, 1976.
35 STONER, G.L.; TOUW, J.; ATLAW, T.; BELEHU, A. Antigen-specific suppressor cells in subclinical leprosy infection. Lancet, 2(8260/61):1372- -1377, 1981.
36 WOLINSKY, E. Non-tuberculous mycobacteria and associated diseases. Amer. Rev. Reap. Dig., 119 (1) : 107-159, 1979.
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Published
1983-06-30
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FLIESS EL, ORTIZ MC, CORN J. Alteración de la inminidad mediada por células frente a Mycobacterium leprae y mycobacterium marinum en pacientes hansenianos. Hansen. Int. [Internet]. 1983 Jun. 30 [cited 2024 May 19];8(1):9-17. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35579
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