Palavras-chave
Hanseníase
Reação reversa
Neurite
Reação reversa
Neurite
Como Citar
1.
CARAYON A. La réaction reverse ou inverse — point actuel. Hansen. Int. [Internet]. 30º de junho de 1981 [citado 26º de dezembro de 2024];6(1):10-8. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35604
Resumo
A reação reversa ou inversa, bem estudada em certos centros de pesquisa, continua ainda mal conhecida, contestada e mesmo negada. Este desconhecimento tem sido uma das causas das dificuldades na compreensão do mecanismo das nevrites hansenianas. Pretendeu-se respigar a evolução dos conceitos sobre essa questão desde Souza Lima e Souza Campos (1940), depois Tajiri (1955), atingindo o conceito atual de reação I de Jopling, que compreende a reação "up grading" e 'down grading", culminando-se por apresentar uma interpretação, cujo mecanismo permite melhor compreensão da fenomenologia clínica e conduta terapêutica mais adequada.
Referências
1 BARNETSON, R.S.; BARNETSON, A.; PEARSON, J.M.; KRONVALL, G. Does nonspecific T-lymphocyte stimulation of B lymphocytes
occur- during reversal reaction in borderline leprosy? Scand. J. Immunol., 5(3) : 287-291, 1976.
2 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, J.M. Antigenic heterogeneity in patients with reactions in borderline leprosy. Br. Med. J., 4(5994) :435-437, 1975.
3 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, -J.M.; KRONVALL, G. Cell mediated and humoral immunity in "reversal reactions". Int. J. Lepr.. 44(1/2) :267-274, 1976.
4 BARNETSON, R.S.; PEARSON, J.M.; REES, R.J. Evidence for prevention of borderline leprosy reactions by dapsone. Lancet, 2(7996): 1171-1172, 1976.
5 BJUNE, G. & BARNETSON, S.R. In vitro lymphocyte response in borderline leprosy reactions. In: INTERNATIONAL LEPROSY
CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2) :396, 1979.
6 B L E N S K A , W . P a t t e r n o f l e p r o s y reactions in Uganda. Int. J. Lepr.. 39 (2) :433-443, 1971.
7 BRYCESON, A. & PFALTZGRAFF, R.E. Leprosy for medicine students. 2. ed. Edinburg, Churchill-Livingstone, 1977.
8 HASTINGS, R.C. Clinical aspects — reactional episodes. In: INTERNATIONAL LEPROSY CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2): 348, 1979.
9 HASTINGS, R.C. & JOB, C.K. Reversal reactions in lepromatous leprosy following transfer factor therapy. Am. J. Trop. Med. Hyg.,
27(5) :995-1004, 1978.
10 JOLLIFFE, D.S. Leprosy reactional states and their treatment. Br. J. Derm., 97 (3) :345-352, 1977.
11 JOPLING, W.H. Handbook of leprosy. 2. ed. London, William Heinemann Medical Books, 1978. 139 p.
12 KARAT, S.; RANNEY, D.A.; KURIAN, H. Rehabilitation of the leprosy patient. Karigiri, Schieffler Leprosy Research, 1975.
13 LANGUILLON, J. Classification et pathogénie des états réactionnels: la nevrite lépreuse. Acta Leprol. (40/41) : 39-49,1970.
14 LANGUILLON, J. La réaction lépreuse. Med. Trop., 25(2) :171-182, 1965.
15 LANGUILON, J. & CARAYON, A. La régression tuberculoide dans la lepre lepromateuse. In: — Precis de léprologie clinique et therapeutique de la lèpre en Afrique Noire. Paris, Masson, 1969, p. 154-160.
1 6 M AH AP A TR A , S.B . & R A M U, G . Transformation from lepromatous to borderline leprosy under clofazimine therapy: a case report. Lepr. India, 48(2) :172-176, 1976.
17 MIRANDA, R.N. Aspectos clínicos da reação na lepra tuberculóide. Publ. Cent. Eat. Leprol., 8(2) :75-78, 1968.
18 NAAFS, B. & WHEATE, H.W. The time interval between the start of antileprosy treatment and the development of reactions in borderline patients. Lepr. Rev., 49 (2) :153-157, 1978.
1 9 N A A F S , B . ; P E A R S O N , J . M . H . ; WHEATE, H.W. Reversal reaction: the prevention of permanent nerve damage comparison of short and long-term steroid treatment. Int. J. Lepr., 47(1):7-12, 1979.
20 NOUSSITOU, F. Some aspects of tuberculoid leprosy and chemotherapeutic trials. Acta Leprol. (74) : 1-32, 1979.
21 RABELLO, F.E. The indeterminante group of hanseniasis and its basic connotation: the polar concept. An evaluation and a refutation of the socalled "spectral" approach. Hansen. Int., 1(2) :111-119, 1976.
22 RABELLO, F.E. Reflexões sobre a doutrina da hanseníase desde Bergen (1973) a México (1978). Rev. Leprol. Fontilles, 12 (1) :11-25, 1979.
23 RIDLEY, D.S. Reactions in leprosy. Lepr. Rev., 40(2) :77-81, 1969.
24 SCOTT, G.C.; RUSSEL, D.A.; BOUGHTON, C.R.; VINCIN, D.R. Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares" or disappearance of clinically apparent disease. Int. J. Lepr., 44(1/2):l10-122, 1976.
25 SOUZA L IM A, L . & SOUZA C AM - POS, N. Lepra tuberculóide. São Paulo, Renascença, 1947, 298 p.
26 TAJIRI, I. The "acute infiltration" reaction of lepromatous leprosy. Int. J. Lepr., 23(4) :370-384, 1955.
occur- during reversal reaction in borderline leprosy? Scand. J. Immunol., 5(3) : 287-291, 1976.
2 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, J.M. Antigenic heterogeneity in patients with reactions in borderline leprosy. Br. Med. J., 4(5994) :435-437, 1975.
3 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, -J.M.; KRONVALL, G. Cell mediated and humoral immunity in "reversal reactions". Int. J. Lepr.. 44(1/2) :267-274, 1976.
4 BARNETSON, R.S.; PEARSON, J.M.; REES, R.J. Evidence for prevention of borderline leprosy reactions by dapsone. Lancet, 2(7996): 1171-1172, 1976.
5 BJUNE, G. & BARNETSON, S.R. In vitro lymphocyte response in borderline leprosy reactions. In: INTERNATIONAL LEPROSY
CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2) :396, 1979.
6 B L E N S K A , W . P a t t e r n o f l e p r o s y reactions in Uganda. Int. J. Lepr.. 39 (2) :433-443, 1971.
7 BRYCESON, A. & PFALTZGRAFF, R.E. Leprosy for medicine students. 2. ed. Edinburg, Churchill-Livingstone, 1977.
8 HASTINGS, R.C. Clinical aspects — reactional episodes. In: INTERNATIONAL LEPROSY CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2): 348, 1979.
9 HASTINGS, R.C. & JOB, C.K. Reversal reactions in lepromatous leprosy following transfer factor therapy. Am. J. Trop. Med. Hyg.,
27(5) :995-1004, 1978.
10 JOLLIFFE, D.S. Leprosy reactional states and their treatment. Br. J. Derm., 97 (3) :345-352, 1977.
11 JOPLING, W.H. Handbook of leprosy. 2. ed. London, William Heinemann Medical Books, 1978. 139 p.
12 KARAT, S.; RANNEY, D.A.; KURIAN, H. Rehabilitation of the leprosy patient. Karigiri, Schieffler Leprosy Research, 1975.
13 LANGUILLON, J. Classification et pathogénie des états réactionnels: la nevrite lépreuse. Acta Leprol. (40/41) : 39-49,1970.
14 LANGUILLON, J. La réaction lépreuse. Med. Trop., 25(2) :171-182, 1965.
15 LANGUILON, J. & CARAYON, A. La régression tuberculoide dans la lepre lepromateuse. In: — Precis de léprologie clinique et therapeutique de la lèpre en Afrique Noire. Paris, Masson, 1969, p. 154-160.
1 6 M AH AP A TR A , S.B . & R A M U, G . Transformation from lepromatous to borderline leprosy under clofazimine therapy: a case report. Lepr. India, 48(2) :172-176, 1976.
17 MIRANDA, R.N. Aspectos clínicos da reação na lepra tuberculóide. Publ. Cent. Eat. Leprol., 8(2) :75-78, 1968.
18 NAAFS, B. & WHEATE, H.W. The time interval between the start of antileprosy treatment and the development of reactions in borderline patients. Lepr. Rev., 49 (2) :153-157, 1978.
1 9 N A A F S , B . ; P E A R S O N , J . M . H . ; WHEATE, H.W. Reversal reaction: the prevention of permanent nerve damage comparison of short and long-term steroid treatment. Int. J. Lepr., 47(1):7-12, 1979.
20 NOUSSITOU, F. Some aspects of tuberculoid leprosy and chemotherapeutic trials. Acta Leprol. (74) : 1-32, 1979.
21 RABELLO, F.E. The indeterminante group of hanseniasis and its basic connotation: the polar concept. An evaluation and a refutation of the socalled "spectral" approach. Hansen. Int., 1(2) :111-119, 1976.
22 RABELLO, F.E. Reflexões sobre a doutrina da hanseníase desde Bergen (1973) a México (1978). Rev. Leprol. Fontilles, 12 (1) :11-25, 1979.
23 RIDLEY, D.S. Reactions in leprosy. Lepr. Rev., 40(2) :77-81, 1969.
24 SCOTT, G.C.; RUSSEL, D.A.; BOUGHTON, C.R.; VINCIN, D.R. Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares" or disappearance of clinically apparent disease. Int. J. Lepr., 44(1/2):l10-122, 1976.
25 SOUZA L IM A, L . & SOUZA C AM - POS, N. Lepra tuberculóide. São Paulo, Renascença, 1947, 298 p.
26 TAJIRI, I. The "acute infiltration" reaction of lepromatous leprosy. Int. J. Lepr., 23(4) :370-384, 1955.
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