Keywords
Hanseniasis
Reversal reaction
Neuritis
Reversal reaction
Neuritis
How to Cite
1.
CARAYON A. La réaction reverse ou inverse — point actuel. Hansen. Int. [Internet]. 1981 Jun. 30 [cited 2024 Nov. 23];6(1):10-8. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35604
Abstract
The reversal or inversal reactions, well studied in some research centers, is still imperfectly known, even contested or denied. This lack of knowledge has been one of the hindrances in the understanding of the mechanism of the hansenic neuritis. The evolution of the concepts about this question is studied, starting with Souza Lima and Souza Campos (1950), followed by Tajiri (1955), up to the present "I reaction" of Jopling, involving the "up grading" and "down grading" reactions. An interpretation of the reactional mechanism is given, with better possibilities for the understanding of clinical aspects and for therapy.
References
1 BARNETSON, R.S.; BARNETSON, A.; PEARSON, J.M.; KRONVALL, G. Does nonspecific T-lymphocyte stimulation of B lymphocytes
occur- during reversal reaction in borderline leprosy? Scand. J. Immunol., 5(3) : 287-291, 1976.
2 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, J.M. Antigenic heterogeneity in patients with reactions in borderline leprosy. Br. Med. J., 4(5994) :435-437, 1975.
3 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, -J.M.; KRONVALL, G. Cell mediated and humoral immunity in "reversal reactions". Int. J. Lepr.. 44(1/2) :267-274, 1976.
4 BARNETSON, R.S.; PEARSON, J.M.; REES, R.J. Evidence for prevention of borderline leprosy reactions by dapsone. Lancet, 2(7996): 1171-1172, 1976.
5 BJUNE, G. & BARNETSON, S.R. In vitro lymphocyte response in borderline leprosy reactions. In: INTERNATIONAL LEPROSY
CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2) :396, 1979.
6 B L E N S K A , W . P a t t e r n o f l e p r o s y reactions in Uganda. Int. J. Lepr.. 39 (2) :433-443, 1971.
7 BRYCESON, A. & PFALTZGRAFF, R.E. Leprosy for medicine students. 2. ed. Edinburg, Churchill-Livingstone, 1977.
8 HASTINGS, R.C. Clinical aspects — reactional episodes. In: INTERNATIONAL LEPROSY CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2): 348, 1979.
9 HASTINGS, R.C. & JOB, C.K. Reversal reactions in lepromatous leprosy following transfer factor therapy. Am. J. Trop. Med. Hyg.,
27(5) :995-1004, 1978.
10 JOLLIFFE, D.S. Leprosy reactional states and their treatment. Br. J. Derm., 97 (3) :345-352, 1977.
11 JOPLING, W.H. Handbook of leprosy. 2. ed. London, William Heinemann Medical Books, 1978. 139 p.
12 KARAT, S.; RANNEY, D.A.; KURIAN, H. Rehabilitation of the leprosy patient. Karigiri, Schieffler Leprosy Research, 1975.
13 LANGUILLON, J. Classification et pathogénie des états réactionnels: la nevrite lépreuse. Acta Leprol. (40/41) : 39-49,1970.
14 LANGUILLON, J. La réaction lépreuse. Med. Trop., 25(2) :171-182, 1965.
15 LANGUILON, J. & CARAYON, A. La régression tuberculoide dans la lepre lepromateuse. In: — Precis de léprologie clinique et therapeutique de la lèpre en Afrique Noire. Paris, Masson, 1969, p. 154-160.
1 6 M AH AP A TR A , S.B . & R A M U, G . Transformation from lepromatous to borderline leprosy under clofazimine therapy: a case report. Lepr. India, 48(2) :172-176, 1976.
17 MIRANDA, R.N. Aspectos clínicos da reação na lepra tuberculóide. Publ. Cent. Eat. Leprol., 8(2) :75-78, 1968.
18 NAAFS, B. & WHEATE, H.W. The time interval between the start of antileprosy treatment and the development of reactions in borderline patients. Lepr. Rev., 49 (2) :153-157, 1978.
1 9 N A A F S , B . ; P E A R S O N , J . M . H . ; WHEATE, H.W. Reversal reaction: the prevention of permanent nerve damage comparison of short and long-term steroid treatment. Int. J. Lepr., 47(1):7-12, 1979.
20 NOUSSITOU, F. Some aspects of tuberculoid leprosy and chemotherapeutic trials. Acta Leprol. (74) : 1-32, 1979.
21 RABELLO, F.E. The indeterminante group of hanseniasis and its basic connotation: the polar concept. An evaluation and a refutation of the socalled "spectral" approach. Hansen. Int., 1(2) :111-119, 1976.
22 RABELLO, F.E. Reflexões sobre a doutrina da hanseníase desde Bergen (1973) a México (1978). Rev. Leprol. Fontilles, 12 (1) :11-25, 1979.
23 RIDLEY, D.S. Reactions in leprosy. Lepr. Rev., 40(2) :77-81, 1969.
24 SCOTT, G.C.; RUSSEL, D.A.; BOUGHTON, C.R.; VINCIN, D.R. Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares" or disappearance of clinically apparent disease. Int. J. Lepr., 44(1/2):l10-122, 1976.
25 SOUZA L IM A, L . & SOUZA C AM - POS, N. Lepra tuberculóide. São Paulo, Renascença, 1947, 298 p.
26 TAJIRI, I. The "acute infiltration" reaction of lepromatous leprosy. Int. J. Lepr., 23(4) :370-384, 1955.
occur- during reversal reaction in borderline leprosy? Scand. J. Immunol., 5(3) : 287-291, 1976.
2 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, J.M. Antigenic heterogeneity in patients with reactions in borderline leprosy. Br. Med. J., 4(5994) :435-437, 1975.
3 B A R N E T S O N , R . S . ; B J U N E , G . ; PEARSON, -J.M.; KRONVALL, G. Cell mediated and humoral immunity in "reversal reactions". Int. J. Lepr.. 44(1/2) :267-274, 1976.
4 BARNETSON, R.S.; PEARSON, J.M.; REES, R.J. Evidence for prevention of borderline leprosy reactions by dapsone. Lancet, 2(7996): 1171-1172, 1976.
5 BJUNE, G. & BARNETSON, S.R. In vitro lymphocyte response in borderline leprosy reactions. In: INTERNATIONAL LEPROSY
CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2) :396, 1979.
6 B L E N S K A , W . P a t t e r n o f l e p r o s y reactions in Uganda. Int. J. Lepr.. 39 (2) :433-443, 1971.
7 BRYCESON, A. & PFALTZGRAFF, R.E. Leprosy for medicine students. 2. ed. Edinburg, Churchill-Livingstone, 1977.
8 HASTINGS, R.C. Clinical aspects — reactional episodes. In: INTERNATIONAL LEPROSY CONGRESS, 11, México, 1978. Transactions apud Int. J. Lepr., 47(Suppl. 2): 348, 1979.
9 HASTINGS, R.C. & JOB, C.K. Reversal reactions in lepromatous leprosy following transfer factor therapy. Am. J. Trop. Med. Hyg.,
27(5) :995-1004, 1978.
10 JOLLIFFE, D.S. Leprosy reactional states and their treatment. Br. J. Derm., 97 (3) :345-352, 1977.
11 JOPLING, W.H. Handbook of leprosy. 2. ed. London, William Heinemann Medical Books, 1978. 139 p.
12 KARAT, S.; RANNEY, D.A.; KURIAN, H. Rehabilitation of the leprosy patient. Karigiri, Schieffler Leprosy Research, 1975.
13 LANGUILLON, J. Classification et pathogénie des états réactionnels: la nevrite lépreuse. Acta Leprol. (40/41) : 39-49,1970.
14 LANGUILLON, J. La réaction lépreuse. Med. Trop., 25(2) :171-182, 1965.
15 LANGUILON, J. & CARAYON, A. La régression tuberculoide dans la lepre lepromateuse. In: — Precis de léprologie clinique et therapeutique de la lèpre en Afrique Noire. Paris, Masson, 1969, p. 154-160.
1 6 M AH AP A TR A , S.B . & R A M U, G . Transformation from lepromatous to borderline leprosy under clofazimine therapy: a case report. Lepr. India, 48(2) :172-176, 1976.
17 MIRANDA, R.N. Aspectos clínicos da reação na lepra tuberculóide. Publ. Cent. Eat. Leprol., 8(2) :75-78, 1968.
18 NAAFS, B. & WHEATE, H.W. The time interval between the start of antileprosy treatment and the development of reactions in borderline patients. Lepr. Rev., 49 (2) :153-157, 1978.
1 9 N A A F S , B . ; P E A R S O N , J . M . H . ; WHEATE, H.W. Reversal reaction: the prevention of permanent nerve damage comparison of short and long-term steroid treatment. Int. J. Lepr., 47(1):7-12, 1979.
20 NOUSSITOU, F. Some aspects of tuberculoid leprosy and chemotherapeutic trials. Acta Leprol. (74) : 1-32, 1979.
21 RABELLO, F.E. The indeterminante group of hanseniasis and its basic connotation: the polar concept. An evaluation and a refutation of the socalled "spectral" approach. Hansen. Int., 1(2) :111-119, 1976.
22 RABELLO, F.E. Reflexões sobre a doutrina da hanseníase desde Bergen (1973) a México (1978). Rev. Leprol. Fontilles, 12 (1) :11-25, 1979.
23 RIDLEY, D.S. Reactions in leprosy. Lepr. Rev., 40(2) :77-81, 1969.
24 SCOTT, G.C.; RUSSEL, D.A.; BOUGHTON, C.R.; VINCIN, D.R. Untreated leprosy: probability for shifts in Ridley-Jopling classification. Development of "flares" or disappearance of clinically apparent disease. Int. J. Lepr., 44(1/2):l10-122, 1976.
25 SOUZA L IM A, L . & SOUZA C AM - POS, N. Lepra tuberculóide. São Paulo, Renascença, 1947, 298 p.
26 TAJIRI, I. The "acute infiltration" reaction of lepromatous leprosy. Int. J. Lepr., 23(4) :370-384, 1955.
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