Immunoglobulin deposits in Erythema Nodosum Leprosum (ENL) JOSEPHINE ANTHON

JOSEPHINE ANTHONY; M. C. VAIDYA; A. DASGUPTA

doi:10.47878/hi.1978.v3.35637

Autores

JOSEPHINE ANTHONY Senior Research Fellow, Cellular Immunology Laboratory. Department of Anatomy All-India Institute of Medical Sciences, New Delhi-110016, India.
M. C. VAIDYA Associate Professor, Cellular Immunology Laboratory, Department of Anatomy, All-India Institute of Medical Sciences, New Delhi-110016, India.
A. DASGUPTA Assistant Professor, Immunology Division, Department of Microbiology, All-India Institute of Medical Sciences, New Delhi-110016, India.

DOI:

https://doi.org/10.47878/hi.1978.v3.35637

Palavras-chave:

Hanseniasis, ENL reaction, Immunology, Immunofluorescence

Resumo

Erythema Nodosum Leprosum (ENL) skin lesions observed by fluorescence microscopy were found to contain immune complexes. While biopsies taken from at least seven ENL lesions contained deposits of immunoglobulin in their vessel walls, twelve of the lesions contained such deposits in the perivascular cell infiltrate. However, immunoglobulin deposits were observed in the dermis of all 25 ENL lesions studied. On the basis of localization of these fluorescent deposits the 25 skin lesions were classified under groups I to III and were correlated with the onset of the reaction. Control biopsies taken from the lepromatous leprosy patients without ENL were uniformly negative for immunoglobulin deposits.

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Referências

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