Palavras-chave
Hanseníase
Dapsona
Genética
Farmacogenética
Terapêutica
Dapsona
Genética
Farmacogenética
Terapêutica
Como Citar
1.
BEIGUELMAN B. Terapêutica da lepra e farmacogenética. Hansen. Int. [Internet]. 30º de junho de 1976 [citado 14º de novembro de 2024];1(1):61-78. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676
Resumo
No presente trabalho foram analisadas algumas características farmacogeneticas que são polimorfismos genéticos humanos e que influenciam a ação da 4,4'-diaminodifenilsulfona (DDS), o medicamento mais amplamente empregado na terapêutica da lepra. Deu-se atenção especial aos polimorfismos da acetiltransferase, da desidrogenase de 6-fosfato de glicose e da NADH redutase de metemoglobina. Além da revisão e análise critica da literatura, foram apresentadas sugestões para novas investigações.
Referências
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8. BEIGUELMAN, B. Taste sensitivity to phenylthiourea and leprosy. Acta Genet. Med. Gemellol., 13(2) :193-196, 1964.
9. BEIGUELMAN, B. & MARQUES, M. B. Taste sensitivity to phenylthiourea and drugs with antileprotic effect. Acta Genet. Med. Gemellol., 13(2): 200-202, 1964.
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11. BEIGUELMAN, B.; PINTO JR., W.; DALL'AGLIO, F. F.; SILVA, E.; VOZZA, J. A. G-6PD deficiency among lepers and healthy people in
Brazil. Acta Genet., (Basel), 18:159-162, 1968.
12. BEIGUELMAN, B.; PINTO JR., W.; EL-GUINDY, M. M.; KRIEGER, H. Factors influencing the level of DDS in blood. Bull. World Health Organ., 51:467-471, 1974.
13. BELDA, W. Resultados preliminares no tratamento da reação hansênica com o dextrosulfenidol. Rev. Bras. Leprol., 37(1/4) :5-16, 1970.
14. BRUCE-CHWATT, L. J. Changing tides of chemotherapy of malaria. Brit. Med. J., 1(5383) :581-586, 1964.
15. COCHRANE, R. G. Critical review of present position of sulfone therapy in leprosy. Trans. Roy. Soc. Trop. Med. Hyg., 44:259-270, 1950.
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18. DeGOWIN, R. L. A review of therapeutic and hemolytic effects of dapsone. Arch. Intern. Med., 120:242-248, 1967.
19. DeGOWIN, R. L.; EPPES, R. B.; POWELL, R. D.; CARSON, P. E. The haemolytic effects of diaphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency. Bull. World Health Organ., 35(2) :165-179, 1967.
20. DESFORGES, J. F.; THAYER, W. W.•' DAWSON, J. P. Hemolytic anemia induced by sulfoxone therapy, with investigation into the mechanisms of its production. Am. J. Med., 27:132-136, 1959.
21. ELLARD, G. A.; GAMMON, P. T.; HELMY, H. S.; REES, R. J. W. Dapsone acetylation and the treatment of leprosy. Nature, 239:159-160, 1972.
22. EVANS, D. A. P.• MANLEY, K. A.; McKUSICK, V. A. Genetic control of isoniazid metabolism in man. Br. Med. J., 1 (5197) :485-491, 1960.
23. EVANS, D. A. P. & WHITE, T. A. Human acetvlation polymorphism. J. Lab. Clin. Med., 68:394-403, 1964.
24. FABRO, S.; SHUMACHER, H.; SMITH, R. L.; STAGG, R. B. L.; WILLIAMS, R. T. The metabolism of thalidomide: some biological effects of thalido- mide and its metabolites. Br. J. Pharmacol., 25:352-362, 1965.
25. GELBER, R.; PETERS, J. H.; GORDON, G. R.; GLAZKO, A. J.; LEVY, L. The polymorphic acetylation of dapsone in man. Clin. Pharmacol. The- rapeut., 12:225-238, 1971.
26. GILLES, H. 1W. & TAYLOR, B. G. The existence of the glucose-6-phosphate dehydrogenase deficiency trait in Nigeria and its clinical implications. Ann. Trop. Med. Parasitol., 55:64-69, 1961.
27. HARRIS, H. & KALMUS, H. Chemical specificity in genetical differences of taste sensitivity. Ann. Eugen., 15:32-45, 1949.
28. HJELM, M. & VERDIER, C. H. D. Biochemical effects of aromatic amines. I. Methaemoglobinaemia, heamolysis and Heinz-body formation induced by 4,4'- diaminodiphenylsulphone. Biochem. Pharmacol., /4:1119-1128, 1965.
29. HOPKINS, C. Y. A sulphur containing substance from the seed of Coringia Orientalis. Canad. J. Res. B., 16:341-344, 1938.
30. HOPKINS, C. Y. Taste differences in compounds having NCS linkage. Canad. J. Res. B., 20:268-273 ,1942.
31. IYER, C. G. S.; LANGUILLON, J.; RAMANUJAM, K.; TARABINI-CAS- TELLANI, G.; TERENCIO DE LAS AGUAS, J.; BECHELLI, L. M.; UEMURA, K.; MARTINEZ DOMINGUEZ, V.; SUNUARESAN, T. Who co-ordinated short-term double-blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients. Bull. World Health Organ., 45:719-732, 1971.
32. JELLIFFE, D. B. Toxic hepatitis caused by diaminocliphenyl-sulphone. Lancet, 260(6670) :1343-1344, 1951.
33. KNIGHT, R. A.; SELIN, M. J.; HARRIS, H. W. Genetic factors influencing isoniazid blood levels in humans. In: CONFERENCE ON CHEMOTHE- RAPY OF TUBERCULOSIS, 18th, Washington, D.C., 1959. Transactions. p.52.
34. LANGUILLON, J. & LINHARD, J. Research on association between genetic factors and leprosy in Africa. In: INTERNATIONAL LEPROSY CON- GRESS, 10th, Bergen, 1973. Transactions apud Int. J. Leprosy, 41(4): 603, 1973.
35. LECHAT, M. F.; BIAS, W. B.; BLUMBERG, B. S.; MELARTIN, L.; QUINTO, R. S.; COHEN, B. H.; TOLENTINO, J. G.; ABALOS, R. M. A con- trolled study of polyraorphisms in serum globulin and glucose-6-phosphate dehydrogenase deficiency in leprosy. Int. J. Leprosy, 36(2) :179-191, 1968.
36. LEIKER, D. L. The mononucleosis syndrome in leprosy patients treated with sulfones. Int. J. Leprosy, 24(4) :402-405, 1966.
37. LEIKER, D. L. & KAMP, H. First results of treatment of leprosy with rifadin. Lepr. Rev., 41(1) :25-30, 1970.
38. LEWGOY, F. & SALZANO, F. M. Dinâmica do gen que condiciona a de- ficiência em G-6-PD na população de Porto Alegre. In: REUNIÃO ANUAL DA SBPC, 17ª, Belo Horizonte, M.G., 1966. Resumo das comunicações. [s.n.t.] apud Ciência e Cultura, 17(2): 152, 1965.
39. LINCOLN, E. M.; STONE, S.; HOFFMAN, O. R. The treatment of miliary tuberculosis with promizole. Bull. Johns Hopkins Hosp., 82:56-75, 1948.
40. LINN, H. W. The use of dapsone in dermatology. Aust. J. Derm., 6:203-207, 1962.
41. LORINCZ, A. L. & PEARSON, R. W. Sulfapyridine and sulfone type drugs in dermatology. Arch. Dermatol., 85(1) :2-16, 1962.
42. MARQUES, M. B. & OPROMOLLA, D. V. A. A talidomida no tratamento da reação leprótica. Rev. Bras. Leprol., 37(1/4) :41-49, 1970.
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