Leprosy therapy and pharmacogenetics
DOI:
https://doi.org/10.47878/hi.1976.v1.35676Keywords:
Hanseniasis, Therapy, Dapsone, Genetics, PharmacogenetinsAbstract
Some pharmacogenetic traits which are human genetic polymorphisms and that influence the action of 4, V-piaminodiphenylsulfone (DDS), the most widely used drug in leprosy therapy, were analysed. Special attention was given to the polymorphisms of acetyltransferase, glucose-6-phosphate dehydrogenase and NADH methemoglobin reductase. Besides the review and critical analysis of the pertinent literature, suggestions for further investigations are presented.
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References
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24. FABRO, S.; SHUMACHER, H.; SMITH, R. L.; STAGG, R. B. L.; WILLIAMS, R. T. The metabolism of thalidomide: some biological effects of thalido- mide and its metabolites. Br. J. Pharmacol., 25:352-362, 1965.
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26. GILLES, H. 1W. & TAYLOR, B. G. The existence of the glucose-6-phosphate dehydrogenase deficiency trait in Nigeria and its clinical implications. Ann. Trop. Med. Parasitol., 55:64-69, 1961.
27. HARRIS, H. & KALMUS, H. Chemical specificity in genetical differences of taste sensitivity. Ann. Eugen., 15:32-45, 1949.
28. HJELM, M. & VERDIER, C. H. D. Biochemical effects of aromatic amines. I. Methaemoglobinaemia, heamolysis and Heinz-body formation induced by 4,4'- diaminodiphenylsulphone. Biochem. Pharmacol., /4:1119-1128, 1965.
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30. HOPKINS, C. Y. Taste differences in compounds having NCS linkage. Canad. J. Res. B., 20:268-273 ,1942.
31. IYER, C. G. S.; LANGUILLON, J.; RAMANUJAM, K.; TARABINI-CAS- TELLANI, G.; TERENCIO DE LAS AGUAS, J.; BECHELLI, L. M.; UEMURA, K.; MARTINEZ DOMINGUEZ, V.; SUNUARESAN, T. Who co-ordinated short-term double-blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients. Bull. World Health Organ., 45:719-732, 1971.
32. JELLIFFE, D. B. Toxic hepatitis caused by diaminocliphenyl-sulphone. Lancet, 260(6670) :1343-1344, 1951.
33. KNIGHT, R. A.; SELIN, M. J.; HARRIS, H. W. Genetic factors influencing isoniazid blood levels in humans. In: CONFERENCE ON CHEMOTHE- RAPY OF TUBERCULOSIS, 18th, Washington, D.C., 1959. Transactions. p.52.
34. LANGUILLON, J. & LINHARD, J. Research on association between genetic factors and leprosy in Africa. In: INTERNATIONAL LEPROSY CON- GRESS, 10th, Bergen, 1973. Transactions apud Int. J. Leprosy, 41(4): 603, 1973.
35. LECHAT, M. F.; BIAS, W. B.; BLUMBERG, B. S.; MELARTIN, L.; QUINTO, R. S.; COHEN, B. H.; TOLENTINO, J. G.; ABALOS, R. M. A con- trolled study of polyraorphisms in serum globulin and glucose-6-phosphate dehydrogenase deficiency in leprosy. Int. J. Leprosy, 36(2) :179-191, 1968.
36. LEIKER, D. L. The mononucleosis syndrome in leprosy patients treated with sulfones. Int. J. Leprosy, 24(4) :402-405, 1966.
37. LEIKER, D. L. & KAMP, H. First results of treatment of leprosy with rifadin. Lepr. Rev., 41(1) :25-30, 1970.
38. LEWGOY, F. & SALZANO, F. M. Dinâmica do gen que condiciona a de- ficiência em G-6-PD na população de Porto Alegre. In: REUNIÃO ANUAL DA SBPC, 17ª, Belo Horizonte, M.G., 1966. Resumo das comunicações. [s.n.t.] apud Ciência e Cultura, 17(2): 152, 1965.
39. LINCOLN, E. M.; STONE, S.; HOFFMAN, O. R. The treatment of miliary tuberculosis with promizole. Bull. Johns Hopkins Hosp., 82:56-75, 1948.
40. LINN, H. W. The use of dapsone in dermatology. Aust. J. Derm., 6:203-207, 1962.
41. LORINCZ, A. L. & PEARSON, R. W. Sulfapyridine and sulfone type drugs in dermatology. Arch. Dermatol., 85(1) :2-16, 1962.
42. MARQUES, M. B. & OPROMOLLA, D. V. A. A talidomida no tratamento da reação leprótica. Rev. Bras. Leprol., 37(1/4) :41-49, 1970.
43. McRAE, D. H.; RUSSEL, D. A.; SCOTT, G. C.; VINCIN, D. R.; SHEPARD, C. C. Four year results in the therapeutic trial of acedapsone (DADDS) in the Karimui, New Guinea. Int. J. Leprosy, 40(2) :222-223, 1972.
44. MENON, N. K. Madras study of two once-weekly regimens. Clinical aspects. Proc. Int. Tuberc. Conf., (New York, 1969). Bull. Int. Union Against Tuberc., 43:271-275, 1970.
45. MIGUEZ ALONSO, A. Tratamento especifico. In: BRASIL. Ministério da Saúde. Serviço Nacional de Lepra. Manual de Leprologia. Rio de Ja- neiro, 1960. p.97-118.
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1976-06-30
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BEIGUELMAN B. Leprosy therapy and pharmacogenetics. Hansen. Int. [Internet]. 1976 Jun. 30 [cited 2024 Jul. 22];1(1):61-78. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35676
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