La función hepática através del espectro clinico de la hanseniasis
DOI:
https://doi.org/10.47878/hi.1980.v5.36103Palavras-chave:
Hanseniasis, Actividad enzimática, Pruebas de función hepáticaResumo
The liver function was studied in 100 hanseniasis patients. They were classified in the following 10 groups: quiescent LL (20 patients), quiescent BL (13 patients), quiescent BB (7 patients), quiescent BT (9 patients), quiescent TT (12 patients), reactional LL (12 patients), reactional BL (10 patients), reactional BB (7 patients) 4 reactional BT (5 patients), reactional TT (5 patients); a comparison was made with a control group (10 healthy individuals). It was found a hyperproteinemia with high levels of globulin and normal levels of albumin in the serum of all clinical forms, and a typical pattern of "light damage hepatic cells" with raised in the enzymatic activity of GOT, GPT and alkaline phosphatase with no changes in turbidity tests and bilirrubinemia, in all reactional patients. The physiopathology of this problem and the types III and IV hypersensitivity phenomena are discussed.
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Referências
AUDISESHA REDDY, M. 1976. Some biochemical aspects of leprosy: a review. Lepr. India, 48(3) :277-285.
BALAKRISHNAN, S. 1976. Biochemical aspects of reactional states in leprosy. Lepr. India, 48(4) :406-412.
BARNETSON, R.S.; BJUNE, G.; PEARSON, J.M.H.; KRONVALL, G. 1976. Cell mediated and humoral immunity in "reversal reactions". In: JOINT LEPROSY RESEARCH CON- FERENCE, 10, Bethesda, 1975 spud Int. J. Lepr., 44(1/2) :267-274.
BECHELLI, L.M. & SAPUPPO, R. 1943. Exploração funcional do fígado dos doentes lepro- matosos com a prova da galactose, Reação de Takata, Reação de Takata-Ucko, Reações de Hijmans V.D. Bergh e prova da santonina. Rev. Bras. Leprol., 11(3) :221-236.
BERNARD, J.C. 1972. Manifestaciones alérgicas viscerales de la lepra. Leprologia, 17(2): 91-102.
BERNARD, J.C. & BROUNSTEIN, M. 1973. Estudio de la cirrosis hepática en la lepra. Leprologia, 18(2):123-134.
BERNARD, J.C. & VAZQUEZ, C.A.J. 1973. Visceral lesions in lepromatous leprosy. Study of sixty necropsies. Int. J. Lepr., 41 (1):94-101.
BESSEY, 0.A.; LOWRY, 0.H.; BROCK, M.J. 1946. Method for rapid determination of alka- line phosphatase with 5 cubic millimeters of serum. J. Biol. Chem., 164:321-329.
BINFORD, C.H.; STORRS, E.E.; WALSH, G.P. 1976. Disseminated infection in the nine-band- ed armadillo (Dasypus novemcinctus) resulting from inoculation with Mycobacterium le- prae. In: JOINT LEPROSY RESEARCH CONFERENCE, 10, Bethesda, 1975 spud Int. J. Lepr., 44(1/2) :80-83.
CASTAGNINO, J.M. 1968. Electroforesis practice. In: ---. Electroforesis : aplicaciones biológicas y clínicas. Buenos Aires, Editorial Universitária de Buenos Aires. cap. 4, p. 63-120.
PACIN, A. et al. La función hepática a través del espectro clínico de la hanseniasis 109
CHEKHERDEMIAN, M. 1960. Determinación del colesterol, fosfolipidos, lipidos totales y proteinas totales y proteinas glucoproteinas y lipoproteinas por electroforeses en las distintas formas de lepra. Leprologia, 5(2) :69-79.
COCHRANE, R.G. 1964. Signs and symptoms. In: COCHRANE, R.G. & DAVEY, T.F., ed. Leprosy in theory and practice. Bristol, J. Wright. p.251-279.
DESIKAN, K.V. & JOB, C.K. 1968. A review of postmortem findings in 37 cases of leprosy. Int. J. Lepr., 36(1) :32-44.
DHOPLE, A.M. & MAGAR, N.G. 1962. Studies in the blood chemistry of leprosy. Lepr. 34(4):299-305.
DRUTZ, D.J.; CHEN, T.S.N.; LU, W.H. 1972 The continuous bacteremia of lepromatous leprosy. New Eng. J. Med., 287(4) :159-164.
FLIESS, E.L. 1976. Inmunopatologia de la lepra. Tem. Leprol., 20(59) :3-32.
FLIESS, E.L. & BACHMANN, A.E. 1977. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Arg. Microbiol., 9:28-36.
FLIESS, E.L. & PACIN, A. 1977. La respuesta inmunológicas a través del espectro clínico de la lepra. Arch. Argent. Derrnatol., 27(2/3) :111-116.
GATTI, J.C.; PETROLITO, J.; CARDAMA, J.E.; CRESPI, H.G.; BIANCHI, O.; KORBEN- FELD, P. 1968. Estudio hepático funcional e histológico en enfermos de lepra. Leprologia, 13(1) :6-10.
GODAL, T.; MYRVANG, V.; SAMUEL, D.R.; ROSS, W.F.; LOFGREN, M. 1973. Mechanism of "reactions" in borderline tuberculoid (BT) leprosy. Acta Pathol. Microbiol. Scand. Section A (suppl. 236) :45-53.
GODAL, T.; MYRVANG, V.; STANFORD, J.L.; SAMUEL, D.R. 1974. Recent advances in the immunolPgy of leprosy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72:273-310.
GUPTA, J.C.; GUPTA, D.K.; GUPTA, A.K. 1974. Hepatic lesions in leprosy. Lepr. India, 46 (4):226-233.
GUPTA, S.C.; SINHA, S.N.; SHARMA, D.; BAJAJ, A.B.; BISHT, D.; MEHROTRA, T.N.; GUPTA, R.M. 1978. Serum proteins and immunoglobulins in leprosy. Int. J. Lepr., 46 (1) :9-13.
HANSEN, G.A. & LOOFT, C. 1894. Die Lepravon klinischen und pathologisch - anatomischen Standpunckt. Hamburgo, T.G. Camel Ed. p. 45.
HARPER, H.A. 1973. Manual de química f isiológica. 3.ed. São Paulo, Atheneu. 570p.
ISSELBACHER, K.J. 1973. Padecimientos del sistema hepatobiliar. In: HARRISON, T.R. Medicina interna. 4.ed. México, La Prensa Médica Mexicana. p.1700-1759.
JENDRASSIK, L. & GROF, P. 1938. Vereinfachte photometrische Methoden zur Bestemmung des Blutbilirubins. Biochera. Ztschr., 297:81-89.
JOB, C.K.; KIRCHHEIMER, W.F.; SANCHEZ, R.M. 1978. Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study. mt. J. Lepr., 46(1):1-8.
JOPLING, W.H. 1974. A classification of leprosy. In: JORNADAS ARGENTINAS DE LEPRO- LOGIA, 8, Buenos Aires, 1974 apud Leprologia, 19(2) :127-132.
KAPOOR, K.K. & GUPTA, S.C. 1974. Serum cholesterol and alkaline phosphatase in different types of leprosy. Lepr. India, 46(3) :152-156.
KEAN, B.H. & CHILDRESS, M.E. 1942. A summary of 103 autopsies on leprosy patients on the isthmus of Panamá. Int. J. Lepr., 10(n.° esp.) :51-59.
KIRCHHEIMER, W.F.; SANCHEZ, R.M.; PASCUA, J.P.; WALSH, T. 1978. Quantitative aspects of experimental infection of armadillos with Mycobacterium leprae. In: JOINT LEPROSY RESEARCH CONFERENCE, 12, Boston, 1977. apud Int. J. Lepr., 46(1): 109-110.
KIRCHHEIMER, W.F.; STORRS, E.E.; BINFORD, C.H. 1972. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study of leprosy. II. Histopatho- logic and bacteriologic post-mortem findings in lepromatoid leprosy in the armadillo. Int. J. Lepr., 40 (3 ) :229-242.
KLINGMULLER, G. & SOBICH, E. 1977. übertragung menschlicher Leprabakterien auf den Igel. Naturwissenschaften, 64:645.
KOLEY, S.K.; DAS, P.K.; GHOSH, S. 1974. Observations on liver biopsies in tuberculoid cases with a single lesion. Indian J. Dermatol., 20:17-21.
MACLAGAN, N.F. 1944. Thymol turbidity: new indicator of liver dysfunction. Brit. J. Exp. Path., 25:234-241.
MARUNA, R.F.L.; GRIINDIG, E.; SIMANYI, M.; WEITHALER, K. 1970. Klinischchemische Untersuchungen mit Seren von Leprapatienten. Ztschr. Tropennted. Parasit., 21 (4) :425-432.
MASANTI, J.G.; MARTINO, 0.A.; CROXATTO, J.0.; BERNARD, J.C.; PtREZ CHADA, R. D.; MÉNDEZ DE FALCON, M.A. 1977. Correlación anátomoclinica en la lepra lepromatosa. Tem. Leprol., 20(62) :3-54.
MELAMED, A.J. 1976. Etiopatogenia de la reacción leprosa. Tem. Leprol., 19(56) :15-16.
MELAMED, A.J. 1962. La reación leprosa. Leprologia, 7(2) :105-123.
MELAMED, A.J. & ABULAFIA, J. 1957. Fenómenos vasculares en la reacción leprosa. Med. Panamer., 9(9) :1-12.
MELAMED, A.J. & BARCIA, A. 1958. El proteinograma seriado en la reacción leprosa tratada con hormonas antiflogisticas. Leprologia, 3(1) :57-67.
MITSTJDA, K. & OGAWA, M. 1937. A study of one hundred and fifty autopsies on cases of leprosy./nt. J. Lepr., 5(1) :53-60.
MOHANTY, H.C. & MURTY, R.S. 1973. Serum transaminase in leprosy Lepr. India, 45(3) : 163-166.
MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. 1973. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the cli- nical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553.
NATH, R.L. & SAHA, D. 1974. A thermostable serum alkaline phosphatase. Clin. Chim. Acta, 55(1) :5-9.
PACIN, A. & FLIESS, E.L. 1978. Estudios enzimáticos en pacientes hansenianos. I. Actividad de las transaminases glutdmico pirávica y glumático oxalacética. Hansen. Int., 3 (2) : 151-159.
PACIN, A. & FLIESS, E.L. 1979. Estudios enzimáticos en pacientes hansenianos: actividad sérica de la fosfatasa alcalina. Leprologia, 21(1) :46-50.
POWELL, C. & SWANN, L. 1955. Pathological changes observed in 50 consecutive necropsies. Am. J. Patkol., 31:1131-1147.
REITMAN, S. & FRANKEL, S. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Cliut. Pathol., 28(1): 56-63.
RHODES-JONES, R. 1963. An investigation into bacillaemia in leprosy. Lepr. Rev., 34(1): 26-28.
RIDLEY, D.S. & JOPLING, W.H. 1966. Classification of leprosy according to immunity. A five group system. Nt. J. Lepr., 34(3) :255-273.
RIVAS, D. 1912. Bacteriemic nature of leprosy. J.A.M.A., 59 (4) :298.
ROSS, H. 1955. The Blood in leprosy: morphology, chemistry, immunology. Part. II. Chemistry. Lepr. Briefs., 6(1) :26-31.
ROSS, H. 1941. Serum phosphatase in leprosy. Int. J. Lepr., 9(1) :57-62.
SEHGAL, V.N.; TYAGI, S.P.; KUMAR, S.; GUPTA, M.C.; HAMEED, S. 1972. Microscopic pathology of the liver in leprosy patients. Int. J. Dermatol., 11(3) :168-172.
SHANK, R.E. & HOAGLAND, C.L. 1946. Modified method for quantitative determination of thymol turbidity reaction of serum. J. Biol. Chem., 162:133-138.
SHANKARA MANJA, K.; BEDI, M.M.S.; KASTUR, G.; KIRCHHEIMER, W.F.; BALASUBRAHMANYAM, M. 1972. Demonstration of Mycobacterium leprae and its viability in the peripheral blood of leprosy patients. Lepr. Rev., 48(4) :181-187.
PACIN. A. et al. La función hepática a través del espectro clínico de la hanseniasis 111
SKINSNES, O.K. 1968. Comparative pathogenesis of mycobacteriosis. Ann. New York Acad. Sci., 154:19-31.
SKINSNES, O.K. 1973. Immunopathology of leprosy: the century in review. Pathology, pathogenesis and the development of classification. Int. J. Lepr., 41(3) :329-360.
SOOD, V.K. & GRUEBER, H.L.E. 1969. Correlation of histopathologic changes in the liver and bone marrow of leprosy patients. Int. J. Lepr., 87(1) :28-39.
STORRS, E.E. 1973. Leprosy in the nine-banded armadillo. Ztschr. Tropenmed. Parasit., 24(1): 53-65.
SURRINDER KAUR; CHAKRAVARTI, R.N.; WAHI, P.L. 1974. Liver pathology in leprosy. Lepr. India, 46(4) :222-225.
TERENCIO DE LAS AGUAS, J. & HIERRO RUIZ, J. 1973. Transaminase and Australia antigen in leprosy. In: INTERNATIONAL LEPROSY CONGRESS, 10, Bergen. Transactions. apud Int. J. Lepr., 41(4) :566, 1973.
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BALAKRISHNAN, S. 1976. Biochemical aspects of reactional states in leprosy. Lepr. India, 48(4) :406-412.
BARNETSON, R.S.; BJUNE, G.; PEARSON, J.M.H.; KRONVALL, G. 1976. Cell mediated and humoral immunity in "reversal reactions". In: JOINT LEPROSY RESEARCH CON- FERENCE, 10, Bethesda, 1975 spud Int. J. Lepr., 44(1/2) :267-274.
BECHELLI, L.M. & SAPUPPO, R. 1943. Exploração funcional do fígado dos doentes lepro- matosos com a prova da galactose, Reação de Takata, Reação de Takata-Ucko, Reações de Hijmans V.D. Bergh e prova da santonina. Rev. Bras. Leprol., 11(3) :221-236.
BERNARD, J.C. 1972. Manifestaciones alérgicas viscerales de la lepra. Leprologia, 17(2): 91-102.
BERNARD, J.C. & BROUNSTEIN, M. 1973. Estudio de la cirrosis hepática en la lepra. Leprologia, 18(2):123-134.
BERNARD, J.C. & VAZQUEZ, C.A.J. 1973. Visceral lesions in lepromatous leprosy. Study of sixty necropsies. Int. J. Lepr., 41 (1):94-101.
BESSEY, 0.A.; LOWRY, 0.H.; BROCK, M.J. 1946. Method for rapid determination of alka- line phosphatase with 5 cubic millimeters of serum. J. Biol. Chem., 164:321-329.
BINFORD, C.H.; STORRS, E.E.; WALSH, G.P. 1976. Disseminated infection in the nine-band- ed armadillo (Dasypus novemcinctus) resulting from inoculation with Mycobacterium le- prae. In: JOINT LEPROSY RESEARCH CONFERENCE, 10, Bethesda, 1975 spud Int. J. Lepr., 44(1/2) :80-83.
CASTAGNINO, J.M. 1968. Electroforesis practice. In: ---. Electroforesis : aplicaciones biológicas y clínicas. Buenos Aires, Editorial Universitária de Buenos Aires. cap. 4, p. 63-120.
PACIN, A. et al. La función hepática a través del espectro clínico de la hanseniasis 109
CHEKHERDEMIAN, M. 1960. Determinación del colesterol, fosfolipidos, lipidos totales y proteinas totales y proteinas glucoproteinas y lipoproteinas por electroforeses en las distintas formas de lepra. Leprologia, 5(2) :69-79.
COCHRANE, R.G. 1964. Signs and symptoms. In: COCHRANE, R.G. & DAVEY, T.F., ed. Leprosy in theory and practice. Bristol, J. Wright. p.251-279.
DESIKAN, K.V. & JOB, C.K. 1968. A review of postmortem findings in 37 cases of leprosy. Int. J. Lepr., 36(1) :32-44.
DHOPLE, A.M. & MAGAR, N.G. 1962. Studies in the blood chemistry of leprosy. Lepr. 34(4):299-305.
DRUTZ, D.J.; CHEN, T.S.N.; LU, W.H. 1972 The continuous bacteremia of lepromatous leprosy. New Eng. J. Med., 287(4) :159-164.
FLIESS, E.L. 1976. Inmunopatologia de la lepra. Tem. Leprol., 20(59) :3-32.
FLIESS, E.L. & BACHMANN, A.E. 1977. Alteración de la inmunidad mediada por células en enfermos de lepra. Rev. Asoc. Arg. Microbiol., 9:28-36.
FLIESS, E.L. & PACIN, A. 1977. La respuesta inmunológicas a través del espectro clínico de la lepra. Arch. Argent. Derrnatol., 27(2/3) :111-116.
GATTI, J.C.; PETROLITO, J.; CARDAMA, J.E.; CRESPI, H.G.; BIANCHI, O.; KORBEN- FELD, P. 1968. Estudio hepático funcional e histológico en enfermos de lepra. Leprologia, 13(1) :6-10.
GODAL, T.; MYRVANG, V.; SAMUEL, D.R.; ROSS, W.F.; LOFGREN, M. 1973. Mechanism of "reactions" in borderline tuberculoid (BT) leprosy. Acta Pathol. Microbiol. Scand. Section A (suppl. 236) :45-53.
GODAL, T.; MYRVANG, V.; STANFORD, J.L.; SAMUEL, D.R. 1974. Recent advances in the immunolPgy of leprosy with special reference to new approaches in immunoprophylaxis. Bull. Inst. Pasteur, 72:273-310.
GUPTA, J.C.; GUPTA, D.K.; GUPTA, A.K. 1974. Hepatic lesions in leprosy. Lepr. India, 46 (4):226-233.
GUPTA, S.C.; SINHA, S.N.; SHARMA, D.; BAJAJ, A.B.; BISHT, D.; MEHROTRA, T.N.; GUPTA, R.M. 1978. Serum proteins and immunoglobulins in leprosy. Int. J. Lepr., 46 (1) :9-13.
HANSEN, G.A. & LOOFT, C. 1894. Die Lepravon klinischen und pathologisch - anatomischen Standpunckt. Hamburgo, T.G. Camel Ed. p. 45.
HARPER, H.A. 1973. Manual de química f isiológica. 3.ed. São Paulo, Atheneu. 570p.
ISSELBACHER, K.J. 1973. Padecimientos del sistema hepatobiliar. In: HARRISON, T.R. Medicina interna. 4.ed. México, La Prensa Médica Mexicana. p.1700-1759.
JENDRASSIK, L. & GROF, P. 1938. Vereinfachte photometrische Methoden zur Bestemmung des Blutbilirubins. Biochera. Ztschr., 297:81-89.
JOB, C.K.; KIRCHHEIMER, W.F.; SANCHEZ, R.M. 1978. Liver lesions in experimental lepromatoid leprosy of the armadillo. A histopathologic study. mt. J. Lepr., 46(1):1-8.
JOPLING, W.H. 1974. A classification of leprosy. In: JORNADAS ARGENTINAS DE LEPRO- LOGIA, 8, Buenos Aires, 1974 apud Leprologia, 19(2) :127-132.
KAPOOR, K.K. & GUPTA, S.C. 1974. Serum cholesterol and alkaline phosphatase in different types of leprosy. Lepr. India, 46(3) :152-156.
KEAN, B.H. & CHILDRESS, M.E. 1942. A summary of 103 autopsies on leprosy patients on the isthmus of Panamá. Int. J. Lepr., 10(n.° esp.) :51-59.
KIRCHHEIMER, W.F.; SANCHEZ, R.M.; PASCUA, J.P.; WALSH, T. 1978. Quantitative aspects of experimental infection of armadillos with Mycobacterium leprae. In: JOINT LEPROSY RESEARCH CONFERENCE, 12, Boston, 1977. apud Int. J. Lepr., 46(1): 109-110.
KIRCHHEIMER, W.F.; STORRS, E.E.; BINFORD, C.H. 1972. Attempts to establish the armadillo (Dasypus novemcinctus Linn) as a model for the study of leprosy. II. Histopatho- logic and bacteriologic post-mortem findings in lepromatoid leprosy in the armadillo. Int. J. Lepr., 40 (3 ) :229-242.
KLINGMULLER, G. & SOBICH, E. 1977. übertragung menschlicher Leprabakterien auf den Igel. Naturwissenschaften, 64:645.
KOLEY, S.K.; DAS, P.K.; GHOSH, S. 1974. Observations on liver biopsies in tuberculoid cases with a single lesion. Indian J. Dermatol., 20:17-21.
MACLAGAN, N.F. 1944. Thymol turbidity: new indicator of liver dysfunction. Brit. J. Exp. Path., 25:234-241.
MARUNA, R.F.L.; GRIINDIG, E.; SIMANYI, M.; WEITHALER, K. 1970. Klinischchemische Untersuchungen mit Seren von Leprapatienten. Ztschr. Tropennted. Parasit., 21 (4) :425-432.
MASANTI, J.G.; MARTINO, 0.A.; CROXATTO, J.0.; BERNARD, J.C.; PtREZ CHADA, R. D.; MÉNDEZ DE FALCON, M.A. 1977. Correlación anátomoclinica en la lepra lepromatosa. Tem. Leprol., 20(62) :3-54.
MELAMED, A.J. 1976. Etiopatogenia de la reacción leprosa. Tem. Leprol., 19(56) :15-16.
MELAMED, A.J. 1962. La reación leprosa. Leprologia, 7(2) :105-123.
MELAMED, A.J. & ABULAFIA, J. 1957. Fenómenos vasculares en la reacción leprosa. Med. Panamer., 9(9) :1-12.
MELAMED, A.J. & BARCIA, A. 1958. El proteinograma seriado en la reacción leprosa tratada con hormonas antiflogisticas. Leprologia, 3(1) :57-67.
MITSTJDA, K. & OGAWA, M. 1937. A study of one hundred and fifty autopsies on cases of leprosy./nt. J. Lepr., 5(1) :53-60.
MOHANTY, H.C. & MURTY, R.S. 1973. Serum transaminase in leprosy Lepr. India, 45(3) : 163-166.
MYRVANG, B.; GODAL, T.; RIDLEY, D.S.; FROLAND, S.S.; SONG, Y.K. 1973. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the cli- nical and histopathological spectrum of leprosy. Clin. Exp. Immunol., 14:541-553.
NATH, R.L. & SAHA, D. 1974. A thermostable serum alkaline phosphatase. Clin. Chim. Acta, 55(1) :5-9.
PACIN, A. & FLIESS, E.L. 1978. Estudios enzimáticos en pacientes hansenianos. I. Actividad de las transaminases glutdmico pirávica y glumático oxalacética. Hansen. Int., 3 (2) : 151-159.
PACIN, A. & FLIESS, E.L. 1979. Estudios enzimáticos en pacientes hansenianos: actividad sérica de la fosfatasa alcalina. Leprologia, 21(1) :46-50.
POWELL, C. & SWANN, L. 1955. Pathological changes observed in 50 consecutive necropsies. Am. J. Patkol., 31:1131-1147.
REITMAN, S. & FRANKEL, S. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Cliut. Pathol., 28(1): 56-63.
RHODES-JONES, R. 1963. An investigation into bacillaemia in leprosy. Lepr. Rev., 34(1): 26-28.
RIDLEY, D.S. & JOPLING, W.H. 1966. Classification of leprosy according to immunity. A five group system. Nt. J. Lepr., 34(3) :255-273.
RIVAS, D. 1912. Bacteriemic nature of leprosy. J.A.M.A., 59 (4) :298.
ROSS, H. 1955. The Blood in leprosy: morphology, chemistry, immunology. Part. II. Chemistry. Lepr. Briefs., 6(1) :26-31.
ROSS, H. 1941. Serum phosphatase in leprosy. Int. J. Lepr., 9(1) :57-62.
SEHGAL, V.N.; TYAGI, S.P.; KUMAR, S.; GUPTA, M.C.; HAMEED, S. 1972. Microscopic pathology of the liver in leprosy patients. Int. J. Dermatol., 11(3) :168-172.
SHANK, R.E. & HOAGLAND, C.L. 1946. Modified method for quantitative determination of thymol turbidity reaction of serum. J. Biol. Chem., 162:133-138.
SHANKARA MANJA, K.; BEDI, M.M.S.; KASTUR, G.; KIRCHHEIMER, W.F.; BALASUBRAHMANYAM, M. 1972. Demonstration of Mycobacterium leprae and its viability in the peripheral blood of leprosy patients. Lepr. Rev., 48(4) :181-187.
PACIN. A. et al. La función hepática a través del espectro clínico de la hanseniasis 111
SKINSNES, O.K. 1968. Comparative pathogenesis of mycobacteriosis. Ann. New York Acad. Sci., 154:19-31.
SKINSNES, O.K. 1973. Immunopathology of leprosy: the century in review. Pathology, pathogenesis and the development of classification. Int. J. Lepr., 41(3) :329-360.
SOOD, V.K. & GRUEBER, H.L.E. 1969. Correlation of histopathologic changes in the liver and bone marrow of leprosy patients. Int. J. Lepr., 87(1) :28-39.
STORRS, E.E. 1973. Leprosy in the nine-banded armadillo. Ztschr. Tropenmed. Parasit., 24(1): 53-65.
SURRINDER KAUR; CHAKRAVARTI, R.N.; WAHI, P.L. 1974. Liver pathology in leprosy. Lepr. India, 46(4) :222-225.
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30-11-1980
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Pacin A, Fliess EL, Llorente BE. La función hepática através del espectro clinico de la hanseniasis. Hansen. Int. [Internet]. 30º de novembro de 1980 [citado 3º de maio de 2024];5(2):93-111. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36103
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Este periódico está licenciado sob uma Creative Commons Attribution 4.0 International License.
