Palavras-chave
Fagocitosis
Lisis
Candida albicans
Candida pseudotropicalis
Neutrófilos
Lisis
Candida albicans
Candida pseudotropicalis
Neutrófilos
Como Citar
1.
Fliess EL, Comesana G, Carrara RC, España A. Fagocitosis y lisis de Candida Albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos de pacientes hansenianos. Hansen. Int. [Internet]. 30º de novembro de 1981 [citado 12º de julho de 2026];6(2):109-13. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36113
Resumo
Se estudió la fagocitosis y lisis de Candida albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos humanos, en 43 pacientes hansenianos. (19 virchowianos quiescentes, 12 virchowianos reaccionales y 12 tuberculoides quiescentes) y 15 testigos sanos. El propósito de este estudio fué determinar si los polimorfonucleares neutrófilos de pacientes hansenianos presentaban alteraciones de sus sistemas enzimáticos mieloperoxidasa-dependientes (investigado mediante lisis de Candida albicans) y mieloperoxidasa independientes (investigado mediante lisis de Candida pseudotropicalis). Los resultados indican que los neutrófilos de los pacientes hansenianos tienen una actividad candidicida similar a la de los neutrófilos de testigos sanos, (p > 0.2) en sus sistemas mieloperoxidasa dependiente e independiente. La actividad de estos sistemas enzimáticos es también similar en todas las formas clínicas de hanseniasis (p > 0.3).
Referências
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2 BARBIERI, T.A. & CORREA, W.M.Human macrophage culture: the leprosy prognostic teat (LPT). Int. J. Lepr.,
85(3):377-381, 1967.
3 BARRANCO, V.P. Inhibition of lysosomal enzymes by dapsone. Arch. Dermatol., 110(4) :563-566, 1974.
4 BEIGUELMAN, B. Fate of Mycobacterium leprae in macrophages. Int. J. Lepr., 89(4) :896-897, 1971.
5 BOYDEM, S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med., 116:463-466, 1962.
6 DRUTZ, D.J. & CLINE, M.J. Polymorphonuclear leukocyte and macrophage function in leprosy. int. J. Lepr., 88(3):362-363, 1970.
7 ESTEVEZ, M.E. & SEN, L. Capacidad funcional de los monocitos humans nomales: una simple técnica para su exploración. Sangre, 28:870-876, 1978.
8 ESTEVEZ, M.E.; SEN, L.; VALDEZ, R.; BALISA, L.M. Defective blood mononuclear phagocyte function in patients with leprosy. Int. J. Lepr., 47(4) :575-579, 1979.
9 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2) :141-150, 1978.
10 GIUNTOLI, J.; ESTEVEZ, M.E.; SEN, L.; PESTALVER, J. Deficiencia funcional de los polimorfonucleares en los enfermos con Talasernia myor. Medicina, 88:836-836, 1978.
11 GODAL, T. & REES, R.J.W. Fate of Mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. Int. J. Lepr., 38 (4) :439-441, 1970.
12 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G. N.B.T. test in lepromatous leprosy. Lancet. 2(7826) :456-457, 1973.
13 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; VILLALBA PIMENTEL, L.; OCANTO, A.; GOMEZ, M.E. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide
in vivo and in vitro Activation in adjuvant disease. Int. Arch Allerg. Appl. Immunol., 57:317-332, 1978.
14 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; CONVIT, J. Polymorphonuclear activation
in leprosy. I. Spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation. Clin. Exp. Immunol., 20: 257-264, 1975.
16 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; PINARDI, M.E.; GOMEZ, M.E.; OCANTO, A.; CONVIT, J. In vitro activation of nutrophils by suspensions of Mycobacterium leprae. Int. J. Lepr., 47(4):570-574, 1979.
16 GOLDE, D.W.; TERRITO, M.; FINLEY, T.N.; CLINE, M.J. Defective lung macrophages in pulmonary alveolar proteinosis. Ann. Intern. Med., 85: 304-309, 1976.
17 KLEBANOFF, S.J. & HAMON, C.B. Role of myeloperoxidase mediated antimicrobial systems in intact leukocytes. J. Reticuloendothel. Soc., 12:170-174, 1972.
18 LACE, J.K.; TAN, J.S.; WATANABUNAKORN, C. An appraisal of the nitroblue tetrazolium reduction test Am. J. Med., 58:686-694, 1975.
19 LEHRER, R.I. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal, myeloperoxidase-deficient and chronic granulomatous disease neutrophils. Infect. Immun., 2:42-47, 1970.
20 MIRANDA, R.N. Celula ativa fagocitária da lepra. Pub. Cent. Eat. Leprol., 16 (1) :70-73, 1976.
21 PETERSON, P.K.P.; VERHOEF, D.; SCHMELING, D.; QUIE, P.G. Kinetics of phagocytosis and bacterial killing
by human polymorphonuclear leukocytes and monocytes. J. Infect. Dis., 186:602-609, 1977.
22 SCHUIT, K.E. Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils. Infect. Immun., 24(3) :932-938, 1979.
23 STENDAHL, O.; MOLIN, L.; DAHLGREN, G. The inhibition of polymorphonuclear leukocyte cytotoxicity by dapsone. J. Clin. Invest., 62:214220, 1978.
2 BARBIERI, T.A. & CORREA, W.M.Human macrophage culture: the leprosy prognostic teat (LPT). Int. J. Lepr.,
85(3):377-381, 1967.
3 BARRANCO, V.P. Inhibition of lysosomal enzymes by dapsone. Arch. Dermatol., 110(4) :563-566, 1974.
4 BEIGUELMAN, B. Fate of Mycobacterium leprae in macrophages. Int. J. Lepr., 89(4) :896-897, 1971.
5 BOYDEM, S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med., 116:463-466, 1962.
6 DRUTZ, D.J. & CLINE, M.J. Polymorphonuclear leukocyte and macrophage function in leprosy. int. J. Lepr., 88(3):362-363, 1970.
7 ESTEVEZ, M.E. & SEN, L. Capacidad funcional de los monocitos humans nomales: una simple técnica para su exploración. Sangre, 28:870-876, 1978.
8 ESTEVEZ, M.E.; SEN, L.; VALDEZ, R.; BALISA, L.M. Defective blood mononuclear phagocyte function in patients with leprosy. Int. J. Lepr., 47(4) :575-579, 1979.
9 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2) :141-150, 1978.
10 GIUNTOLI, J.; ESTEVEZ, M.E.; SEN, L.; PESTALVER, J. Deficiencia funcional de los polimorfonucleares en los enfermos con Talasernia myor. Medicina, 88:836-836, 1978.
11 GODAL, T. & REES, R.J.W. Fate of Mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. Int. J. Lepr., 38 (4) :439-441, 1970.
12 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G. N.B.T. test in lepromatous leprosy. Lancet. 2(7826) :456-457, 1973.
13 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; VILLALBA PIMENTEL, L.; OCANTO, A.; GOMEZ, M.E. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide
in vivo and in vitro Activation in adjuvant disease. Int. Arch Allerg. Appl. Immunol., 57:317-332, 1978.
14 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; CONVIT, J. Polymorphonuclear activation
in leprosy. I. Spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation. Clin. Exp. Immunol., 20: 257-264, 1975.
16 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; PINARDI, M.E.; GOMEZ, M.E.; OCANTO, A.; CONVIT, J. In vitro activation of nutrophils by suspensions of Mycobacterium leprae. Int. J. Lepr., 47(4):570-574, 1979.
16 GOLDE, D.W.; TERRITO, M.; FINLEY, T.N.; CLINE, M.J. Defective lung macrophages in pulmonary alveolar proteinosis. Ann. Intern. Med., 85: 304-309, 1976.
17 KLEBANOFF, S.J. & HAMON, C.B. Role of myeloperoxidase mediated antimicrobial systems in intact leukocytes. J. Reticuloendothel. Soc., 12:170-174, 1972.
18 LACE, J.K.; TAN, J.S.; WATANABUNAKORN, C. An appraisal of the nitroblue tetrazolium reduction test Am. J. Med., 58:686-694, 1975.
19 LEHRER, R.I. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal, myeloperoxidase-deficient and chronic granulomatous disease neutrophils. Infect. Immun., 2:42-47, 1970.
20 MIRANDA, R.N. Celula ativa fagocitária da lepra. Pub. Cent. Eat. Leprol., 16 (1) :70-73, 1976.
21 PETERSON, P.K.P.; VERHOEF, D.; SCHMELING, D.; QUIE, P.G. Kinetics of phagocytosis and bacterial killing
by human polymorphonuclear leukocytes and monocytes. J. Infect. Dis., 186:602-609, 1977.
22 SCHUIT, K.E. Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils. Infect. Immun., 24(3) :932-938, 1979.
23 STENDAHL, O.; MOLIN, L.; DAHLGREN, G. The inhibition of polymorphonuclear leukocyte cytotoxicity by dapsone. J. Clin. Invest., 62:214220, 1978.
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