Fagocitosis y lisis de Candida Albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos de pacientes hansenianos
DOI:
https://doi.org/10.47878/hi.1981.v6.36113Keywords:
Phagocytósis, Lysis, Candida albicans, Candida pseudotropicalis, NeutrophilsAbstract
The phagocytosis and lysis of Candida albicans and Candida pseudotropicalis by human neutrophils were examined in 43 hanseniasis patients (19 quiescent virchowians, 12 reactional virchowians and 12 tuberculoid patients) and 15 healthy subjects. The purpose of this study was to determine whether neutrophils from hanseniasis patients were altered in their enzyme systems myeloperoxidase-dependent (tested by lysin of Candida albicans) and myeloperoxidase-independent (tested by lysin of Candida pseudotropicalis). The results indicate that polymorphonuclear neutrophils of hanseniasis patients had a similar candidacidal activity that human normal neutrophils (p > 0.2) in their myeloperoxidase-dependent and myeloperoxidase-independent systems. The enzymatic system activity is also similar in all the clinical forms of hanseniasis (p > 0.3).
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References
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19 LEHRER, R.I. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal, myeloperoxidase-deficient and chronic granulomatous disease neutrophils. Infect. Immun., 2:42-47, 1970.
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21 PETERSON, P.K.P.; VERHOEF, D.; SCHMELING, D.; QUIE, P.G. Kinetics of phagocytosis and bacterial killing
by human polymorphonuclear leukocytes and monocytes. J. Infect. Dis., 186:602-609, 1977.
22 SCHUIT, K.E. Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils. Infect. Immun., 24(3) :932-938, 1979.
23 STENDAHL, O.; MOLIN, L.; DAHLGREN, G. The inhibition of polymorphonuclear leukocyte cytotoxicity by dapsone. J. Clin. Invest., 62:214220, 1978.
2 BARBIERI, T.A. & CORREA, W.M.Human macrophage culture: the leprosy prognostic teat (LPT). Int. J. Lepr.,
85(3):377-381, 1967.
3 BARRANCO, V.P. Inhibition of lysosomal enzymes by dapsone. Arch. Dermatol., 110(4) :563-566, 1974.
4 BEIGUELMAN, B. Fate of Mycobacterium leprae in macrophages. Int. J. Lepr., 89(4) :896-897, 1971.
5 BOYDEM, S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med., 116:463-466, 1962.
6 DRUTZ, D.J. & CLINE, M.J. Polymorphonuclear leukocyte and macrophage function in leprosy. int. J. Lepr., 88(3):362-363, 1970.
7 ESTEVEZ, M.E. & SEN, L. Capacidad funcional de los monocitos humans nomales: una simple técnica para su exploración. Sangre, 28:870-876, 1978.
8 ESTEVEZ, M.E.; SEN, L.; VALDEZ, R.; BALISA, L.M. Defective blood mononuclear phagocyte function in patients with leprosy. Int. J. Lepr., 47(4) :575-579, 1979.
9 FLIESS, E.L. Posible origen de la inmunodeficiencia en la hanseniasis virchowiana. Hansen. Int., 3(2) :141-150, 1978.
10 GIUNTOLI, J.; ESTEVEZ, M.E.; SEN, L.; PESTALVER, J. Deficiencia funcional de los polimorfonucleares en los enfermos con Talasernia myor. Medicina, 88:836-836, 1978.
11 GODAL, T. & REES, R.J.W. Fate of Mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. Int. J. Lepr., 38 (4) :439-441, 1970.
12 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G. N.B.T. test in lepromatous leprosy. Lancet. 2(7826) :456-457, 1973.
13 GOIHMAN-YAHR, M.; CONVIT, J.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; VILLALBA PIMENTEL, L.; OCANTO, A.; GOMEZ, M.E. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide
in vivo and in vitro Activation in adjuvant disease. Int. Arch Allerg. Appl. Immunol., 57:317-332, 1978.
14 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; CONVIT, J. Polymorphonuclear activation
in leprosy. I. Spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation. Clin. Exp. Immunol., 20: 257-264, 1975.
16 GOIHMAN-YAHR, M.; RODRIGUEZ OCHOA, G.; ARANZAZU, N.; PINARDI, M.E.; GOMEZ, M.E.; OCANTO, A.; CONVIT, J. In vitro activation of nutrophils by suspensions of Mycobacterium leprae. Int. J. Lepr., 47(4):570-574, 1979.
16 GOLDE, D.W.; TERRITO, M.; FINLEY, T.N.; CLINE, M.J. Defective lung macrophages in pulmonary alveolar proteinosis. Ann. Intern. Med., 85: 304-309, 1976.
17 KLEBANOFF, S.J. & HAMON, C.B. Role of myeloperoxidase mediated antimicrobial systems in intact leukocytes. J. Reticuloendothel. Soc., 12:170-174, 1972.
18 LACE, J.K.; TAN, J.S.; WATANABUNAKORN, C. An appraisal of the nitroblue tetrazolium reduction test Am. J. Med., 58:686-694, 1975.
19 LEHRER, R.I. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal, myeloperoxidase-deficient and chronic granulomatous disease neutrophils. Infect. Immun., 2:42-47, 1970.
20 MIRANDA, R.N. Celula ativa fagocitária da lepra. Pub. Cent. Eat. Leprol., 16 (1) :70-73, 1976.
21 PETERSON, P.K.P.; VERHOEF, D.; SCHMELING, D.; QUIE, P.G. Kinetics of phagocytosis and bacterial killing
by human polymorphonuclear leukocytes and monocytes. J. Infect. Dis., 186:602-609, 1977.
22 SCHUIT, K.E. Phagocytosis and intracellular killing of pathogenic yeasts by human monocytes and neutrophils. Infect. Immun., 24(3) :932-938, 1979.
23 STENDAHL, O.; MOLIN, L.; DAHLGREN, G. The inhibition of polymorphonuclear leukocyte cytotoxicity by dapsone. J. Clin. Invest., 62:214220, 1978.
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Published
1981-11-30
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Fliess EL, Comesana G, Carrara RC, España A. Fagocitosis y lisis de Candida Albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos de pacientes hansenianos. Hansen. Int. [Internet]. 1981 Nov. 30 [cited 2024 May 14];6(2):109-13. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36113
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This journal is licensed under a Creative Commons Attribution 4.0 International License.
