Talidomida
uma revisão de literatura
DOI:
https://doi.org/10.47878/hi.1981.v6.36117Palavras-chave:
Hanseníase, Reação Hansênica, Talidomida, TerapêuticaResumo
Procedeu-se a uma revisão bibliográfica extensiva sobre a talidomida, em seus aspectos farmacológicos, metabólicos, teratogenicidade e especialmente quanto às suas aplicações terapêuticas em Dermatologia, destacando-se o uso na reação hansênica.
Downloads
Não há dados estatísticos.
Referências
BACH, A. et al. Studies on the possible antineoplastic effect of thalidomide. Acta Path. Microbiol. Scand., 59:491-499, 1963.
BORE, P.J. et al. Effects of thalidomide on survival of skin homographs in rabbits. Lancet, 1:1240-1241, 1966.
BURLEY, D.M. Is thalidomide to blame? Brit. Med. J., 1:130, 1961.
CALVO, R. & MUCKTER, H. Sur le mécanisme d'action de la thalidomide et autres imides cycliques dans la réaction lépreuse. Acta Leprol. (48/49) :27-29, 1972.
CERRUTI, M.P.;BORRONE,C.; TAMBUSSI, A.M. Ricerche sperimentali sull'effetto dell'imide dell'accido Nftalil-glutammico (Talidomide) sulla sintesi degli anticorpi. Risposta all'iniezione di albumina umana. Minerva Pediatr., /5:13921394, 1963.
DUKOR, P. et al. Immunosuppression by thalidomide. Lancet, 1:569-570, 1967.
FABRO, S. et al. The metabolism of thalidomide: some biological effects of thalidomide and its metabolites. Brit. J. Pharmacol., 25:352-362, 1965.
FAIGLE, J.W. The metabolic fate of thalidomide. Experentia, 18(9) :389-397, 1962.
FIELD, E.O. et al. Effect of thalidomide on the graft vs host reaction. Nature, 211: 1308-1310, 1969.
GOIHMAN-YAHR, M. et al. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide in vivo and in vitro. Activation in adjuvant disease. Int. Arch. Allerg. Appl. Immunol., 57(4):317-332, 1978.
GUSDON Jr., J.P. et al. Effect of thalidomide on the antibody response. Amer. J. Obstet. Gynec., 100:952-956, 1968.
HANAUSKE-ABEL, H. & GUNZLER, V. Inhibition of human prolyl hydroxylase as common biochemical denominator of the non-sedative effects of thalidomide in man. Int. J. Lepr., 46:449, 1978.
HASTINGS, R.C. Mechanism of halidomide action in HD. Star, 94 (2) :1,15, 1974.
HELLMANN, K.; DUKE, D.I.; TUCKER, D.F. Prolongation of skin homograft survival by thalidomide. Brit. Med. J., 2 (5463) :687-689, 1965.
KUNS, W.K. & MUCKTER, H. N-Phthalylglutaminsaüreimid. Arzneimittelforsch, 6: 426-430, 1956.
LOCKER, D.; SUPERSTINE, E.; SULMAN, F.G. The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues. Arch. Int. Pharmacodyn. Therm., 194:39-55, 1971.
OGILVIE, J.W. et a1. The effect of thalidomide on the immune response. Fed. Proc., 27:494, 1968.
OLIVEIRA e SILVA, C. et al. Influência da talidomida sobre os linfócitos circulantes na hanseníase virchowiana.
Bol. Div. Nac. Lepra, 29:77-84, 1973.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the fat of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmecol., 25:338-351, 1965.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution. Brit. J. Pharmacol., 25:324-337, 1965.
SHÉSKIN, J. Influencia de la talidomida, esteroides, analgésicos y placebos sobrela velocidad de la conducción motors en la neurites cubital reaccional. Med. Cut., 4(5) :459-464, 1970.
SOMERS, G.F. Pharmacological properties of thalidomide (alfaphthalamide glutarimide) a new sedative hipnotic drug. Brit. J. Pharmacol., 15:111-116, 1960.
SOUZA, L.P. Thalidomide. Brit. Med. J., 2 (5152) :635, 1959.
THOMAS, E.M. et al. Efeito da talidomida sobre os linfócitos e imunoglobulinas G.A e M no sanguesirculante de pessoas normais. Bol. Div. Nac. Dermat. Sanit., 34 (1/4) :73-79, 1975.
TURK, J.L. et al. Effect of thalidomide on the immunological response in local lymph nodes after a skin homograft. Lancet, 1: 1134, 1966.
ULRICH, M.; SALAS, B.; CONVIT, J. Thalidomide activity in experimental arthus and anaphylactic reactions. Int. J.
Lepr., 89(2):131-135, 1971.
WINTER, C.A. Nonsteroid antiinflammatory agents. Ann. Rev. Pharmacol., 6:157-174, 1966.
WOODYATT, P.B. Thalidomide. Lancet, 1: 750, 1962.
3. Efeitos colaterais. Teratogenicidade
BARTHOLOMEW, A.A. Neuropathy after thalidomide. Brit. Med. J., 2(5266) : 15701571, 1961.
BOHM, R. & NITSCH, K. Another chance for thalidomide? Lancet, 1:92, 1966.
BURLEY, D.M. Overdosage with thalidomide. Med. World, 98(1).:26-28, 1960.
CHEVENS, L.C.F. Neuropathy after thalidomide. Brit. Med. J., 2(5258) :1025, 1961.
CHEYMOL, J. Le drame du thalidomide. Rev. Ass. Med. Bras., 11(4) :123-134, 1965.
FIELD, K.W.G.H. Neuropathy after thalidomide. Brit. Med. J., 2:1084, 1961.
FURLLETON, P.M. et al. Neuropathy after intake of thalidomide. Brit. Med. J., 2: 855-858, 1961.
GOIHMAN-YAHR, M. et aI. Autoimmune diseases and thalidomide. I. Experimental allergic encephalomyelitis
and experimental allergic neuritis of the Guinea Pig. Int. J. Lepr., 40(2) :133-141, 1972.
KELSEY, F.O. Events after thalidomide. J. Dent. Res., 46:1201-1205, 1967.KERBELE, H. et al. Biochemical effects of
drugs on the anormalian concepts. Ann. N.Y. Acad. Sei., 123:252-262, 1965.
LENZ, W. Thalidomide and congenital abnormalities. Lancet, 1 :272, 1962.
LENZ, W. Thalidomide and congenital anomalies. Lancet, 1:45, 1962.
McCREDIE, J. & McLEOD, J.G. Thalidomide and embryonic neuropathy. Lancet, 1 (7866) :1111, 1974.
MAGORA, A. et al. Controlled follow-up assessment of the effect of thalidomide upon the ulnar nerve in leprosy. Int. J. Lepr., 89(4) :863-871, 1971.
MELLIN, G.W. & KATZENSTEIN, M. The saga of thalidomide: neuropathy to embryopathy with case reports of
congenital anomalies. N. Engl. J. Med., 267(23): 1184-1193, 1962.
MELLIN, G.W. & KATZENSTEIN, M. The saga of thalidomide: neuropathy to embryopathy with case reports of
congenital anomalies (Concluded) N. Engl. J. Med., 267(24) :1238-1244, 1962.
MENGONI, H.R. et al. Talidomida: droga teratogenica y su indicación en la reacción leprosa: esquema terapêutico. Leprologia, 14(2):194-206, 1969.
MURAD, J.A. Moléculas teratogênicas. Hospital, 72:299, 1967.
ROATH, S.; ELVES, M.W.; ISRAELS, M.C.G. Effects of thalidomida and its derivatives on human leucocytes
cultured in vitro. Lancet, 1(7275) :249-250, 1963.
SABIN, T.D. Thalidomide neuropathy and leprous neuritis. Lancet, 1(7849) :165-166, 1974.
SAGHER, F. & SHESKIN, J. Réaction lépreuse et thalidomide. Etudes imunologiques. Acts Leprol. (48/49):11-26, 1972.
SHANNON, E.J.; MIRANDA, R.O.; HASTINGS, R.C. Inhibition of the novo antibody synthesis by thalidomide. Int. J.
Lepr., 46(1) :120, 1978.
SHESKIN, J. & SAGHER, F. Erupción tipo dermatitis herpetiforme en enfermos del mal de Hansen tratados con talidomida. Rev. Leprol. Fontilles, 7:229, 1968.
TAUSSIG, H.B. A study of the German outbreak of phocomelia. The thalidomide syndrome. JAMA, 180:1106, 1962.
WEMAMBU, S.N.C. et al. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933935, 1969.WOOLLAM, D.H.M. Principles of teratogenesis: mode of action of thalidomide. Proc. Roy. Soc. Med., 68(7) :497-501, 1965.
4. Emprego na reação hansênica
ACEVES ORTEGA, R. Algunos hechos recientes en terapéutica dermatologica. Reacción leprosa y talidomida. Otros usos de Ias sulfonas. Medicina, 61(1119) :530537, 1971.
AITKEN, G. La thalidomide dans les états de réaction lépreux. Paris, 1968. / These/ 135p.
ALMEIDA, R. Considerações sobre o uso da talidomida na reação leprótica. Rovisco Pais: rev. port. doença Hansen, 11(4) : 365-369, 1972.
ARGUELLO PITT, L. et al. Acción de la talidomida en la reacción leprosa. Leprologia, 18(1):18-26, 1973.
BALISA, L.M. et al. La talidomida en los episódios reaccionales de la lepra. Leprologia, 14(2) :189-193, 1969.
BARBOSA, A. & ALMEIDA, B. A talidomida no tratamento da lepro-reação. Rovisco Pais: rev. port. doença Hansen, 8(28): 23-33, 1969.
BELDA, W. A talidomida no controle da dor nas neurites lepróticas. Hospital, 70(3): 231-237, 1966.
CAZORT, R.T. et ah A trial of thalidomide in progressive lepra reaction. Curr. Ther. Res., 8:299-311, 1966.
CONVIT, J.; SOTO, J.M.; SHESKIN, J. Thalidomide therapy in the lepra reaction. Int. J. Lepr., 35(4) :446-451, 1967.
CRAWFORD, C.L. Thalidomide in erythema nodosum leprosum. Lancet, 2(7839):12011202, 1973.
DEGOS, R. et al. Action rapidement résolutive de la thalidomide sur les poussées de la lèpre. Bull. Soc. Franc. Dermat. Syphil., 78(5) :474-478, 1966.
DUPERRAT, B. et al. Hansen L: action de la thalidomide sur une poussée gravissime. Bull. Soc. Franc. Dermat. Syphil., 78(3) : 291-292, 1971.
EMPLEO de la talidomida en la reacción leprosa. Salud Publ. Mex., 18 (4) :777-779, 1976.
GAY PRIETO, J. Tratamiento de Ias reacciones leprosas con talidomida. Med. Cut., 2:117, 1967.
GONZALEZ-BENAVIDEZ, J. & HERNANDEZ, G.E. Talidomida y reacción leprosa. In: CONGRESO MEXICANO DE
DERMATOLOGIA, 5, México, 1969. Memórias. México, 1970. p. 471-475.
HASTINGS, R.C. et al. Thalidomide in treatment of erythema nodosum leprosum. Clin. Pharm. Ther., 11(4) :481-487, 1970.
ISLA CARANDE, E. Lepra y talidomida. Actas Dermosifiliogr., 99(3/4) :139-200, 1968.
IYER, C.G.S. et al. WHO co-ordinated shortterm double-blind trial with thalidomide in the treatment of acute
lepra reactions in male lepromatous patients. Bull. WHO, 46(6):719-732, 1971.
KHRIKOU, N.A. Results of treatment of leprosy patients with thalidomide. Sci. Works Lepr. Res. Inst., 9/14:88-90,
1976.
KLUKEN, N. & WENTE, W. Indications for thalidomide therapy for leprosy. Int. J. Dermatol., 13 (1) :20-25, 1974.
LANGUILLON, J. Action de deux nouveaux produits: la thalidomide et le B.663 sur les formes réactionnelles de la maladie de Hansen. C.R. Inst. Marchoux, 10(2): 34-41, 1969.
LANGUILLON, J. Action de la thalidomide sur la réaction lépreuse. Acts Leprol., (40/41) :51-55, 1970.
LANGUILLON, J. The effects of thalidomide on leprosy reaction. Int. J. Lepr., 39 (2): 590-592, 1971.
LA ROSA, P. & CASCIANO, A. Reazioni lebbrose e talidomide. Minerva Dermat., 48(4) :166-168, 1968.
LATAPI, F.; SAÚL, A.; GÓMEZ-VIDAL, M. Talidomida en el tratamiento de la reacción leprosa: tres anos de experiencia en México. Gac. Med. Mere., 99(10) :917-930, 1969.
LAVALLE, P. Comentário oficial /Talidomida en el tratamiento de la reacción leprosa/Gac. Med. Mex., 99(10):930-
931, 1969.
LEVY, L. et al. Treatment of erythema nodosum leprosum with thalidomide. Lancet, 2 (7824) :324-325, 1973.
LOVIO CARDE13AS, Z. et al. Empleo de la talidomida en la reacción leprosa. Estudio en la provincia de la Habana. Bol. Hig. Epid., 12(2) :141-146, 1974.
MAGORA, A.; SHESKIN, J.; SAGHER, F. Motor conduction velocity test of the ulnar nerve in leprosy reaction underthalidomide therapy. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4) : 624, 1968.
MARQUES, B. & OPROMOLLA, D.V.A. Thalidomide in treatment of lepra reaction. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4) :637, 1968.
MATTOS, O. & ALONSO, A.M. Treatment of leprosy reaction with thalidomide. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4):642-643, 1968.
MELAMED, J. Acción de la talidomida en el tratamiento de la reacción leprosa. Rev. Argent. Derm., 58(7): — , 1969.
MERKLEN, F.P. et al. Deuce eas d'ineficacité antireactionelle de la thalidomide dans la lèpre. Bull. Soc. Franç. Derm. Syphiligr., 75:638, 1968.
MOHR, W. Thalidomide in leprosy therapy. Int. J. Lepr., 39(2):598-599, 1971.
NETTO, L.S. Talidomida nas reações lepróticas. Rev. Bras. Med., 24 (9) :760-763, 1967.
OCAMPO, J.C.; GATTI, J.C.; CARDAMA, J.E. Tratamiento de la lepra en reacción. Rev. Leprol. Fontilles, 10(3):269-280, 1975.
OPROMOLLA, D.V.A.; LIMA, L.S.; MARQUES, M.B. A talidomida nos surtos agudos de lepra: eritema nodoso ou polimorfo. Hospital, 69(4) :191-208, 1966.
OSSWALD, W. Reacção leprosa e talidomida. Rovisco Pais: rev. port. doença Hansen, 7(24) :34-36, 1968.
PEARSON, J.M.H. & VEDAGIRI, M. Treatment of moderately senere erythema nodosum leprosum with thalidomide — A double blind controlled trial. Lepr. Rev., 40(2) :111-116, 1969.
PETTIT, J.H.S. & WATERS, M.F.R. The etiology of erythema nodosum leprosum. Int. J. Lepr., 35 (1) :1-10, 1967.
RODRIGUEZ, E.; RAMIREZ, J.; YAMBAY, J. Talidomida en reacción leprosa. Dermatologia: rev. mex.,13 (2) :147-151, 1969.
SAMPAIO, S.A.P. & PROENÇA, N. Tratamento da reação leprótica pela talidomida. Rev. Paul. Med., 68:301, 1966.
SAY)L, A. Reacción leprosa y talidomida: resultados del tratamiento de 30 casos. Prensa Med. Mex., 34(11/12) :403-409, 1969.
SAÚL, A. Talidomida en el tratamiento dela reacción leprosa. Primeras observaciones en México. Medicina: rev.
mex., 47: 348-353, 1965.
SAIYL, A. Talidomidodependencia y talidomidorresistencia. Leprologia, 19(2):253-260, 1974.
SHESKIN, J. Fifty month's use of thalidomide in leprosy reaction. Star, 28(6) :3, 1969.
SHESKIN, J. Further observation with thalidomide in lepra reaction. Lepr. Rev., 86(4):183-185, 1965.
SHESKIN, J. Incorporación de la talidomida al arsenal terapéutico del mal de Hansen. Actas Dermosifiliogr., 60 (3/4) :57-72, 1969.
SHESKIN, J. Influencia de la talidomida en la reacción leprosa. Derm. Venez., 4 (3/4) :210-221, 1964/1965.
SHESKIN, J. Recent experience with thalidomide in Hansen's disease. Int. J. Dermat., 9 (1) :56-58, 1970.
SHESKIN, J. Study with nine thalidomide derivatives in lepra reaction. Int. J. Dermat., 17:82-84, 1978.
SHESKIN, J. Thalidomide in lepra reaction. Int. J. Dermat., 14(8) :575-576, 1976.
SHESKIN, J. Thalidomide in the treatment of lepra reactions. Clin. Pharmacol. Ther., 6(3) :303-306, 1965.
SHESKIN, J. The treatment of lepra reaction in lepromatous leprosy. Fifteen years experience with thalidomide. Int. J. Der- mat., 19(6) :318-322, 1980.
SHESKIN, J. & CONVIT, J. Results of a double-blind study of the influence of thalidomide on the lepra reaction. Int. J. Lepr., 87(2) :135-146, 1969.
SHESKIN, J. & CONVIT, J. Therapy of the lepra reaction with thalidomide. A double-blind study. Hautarzt, 17:548-549, 1965.
SHESKIN, J. & SAGHER, F. Encuesta mundial sobre el use de la talidomida en la leprorreacción. Med. Cut. Iber. Lat. Amer., 8 (1) :81-83, 1975.
SHESKIN, J. & SAGHER, F. Five year's experience with thalidomide treatment in leprosy reaction. Int. J. Lepr., 89 (2) : 585-588, 1971.
SHESKIN, J. & SAGHER, F. The present status of thalidomide treatment in lepra reaction on leprosy. In: INTERNATIONAL LEPROSY CONGRESS, 9, London,1968. Transactions. Int. J. Lepr., 86(4) : 637, 1968.
SHESKIN, J. & SAGHER, F. Trials with thalidomide derivatives in leprosy reactions. Lepr. Rev., 89(4) :203-206, 1968.
SHESKIN, J. & ZAUBERMAN, H. Iridocyclitis in lepra reaction treated with thalidomide. Lepr. Rev., 41(4) :233-236,
1970.
SHESKIN, J. et al. Unsatisfactory results with thalidomide as a specific treatment for leprosy. J. Med. Sci., 4:901-907, 1968.
SWIFT, T.R. Thalidomide in erythema nodosum leprosum. Lancet, 2(7835) :966, 1973.
TARABINI-CASTELLANI, G. Tratamiento de las leprorreacciones con talidomida. Rev. Leprol. Fontilles, 6(8) :719-723, 1967.
TERENCIO DE LAS AGUAS, J. Seis anos de experiencia con talidomida. Rev. Leprol. Fontilles, 8(5) :587-598, 1972.
TERENCIO DE LAS AGUAS, J. Thalidomide in the treatment of lepra reactions. Int. J. Lepr., 39 (2) :593-597, 1971.
TERENCIO DE LAS AGUAS, J. & CONTRERAS DUES AS, F. Primeros resultados del tratamiento de las leprorreacciones con talidomida. Rev. Leprol. Fontilles,
6(5) :449-455, 1966.
TERENCIO DE LAS AGUAS, J. & CONTRERAS DUERAS, F. Tratamiento de las leprorreacciones con talidomida.
Rev. Leprol. Fontilles, 7(1) :1-21, 1968.
TERENCIO DE LAS AGUAS, J. & ROSTOLL, F. Thalidomide in treatment of leprous reactions. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4): 644, 1968.
TRIMIGLIOZZI, G. La thalidomide nelle "reazioni" lebbrose. Gior. Ital. Dermat., 107:1353-1365, 1966.
TRIMIGLIOZZI, G. Ulteriori osservazioni sull'imprego della thalidomide nelle "reazioni" lebbrose. Gior. Ital. Dermat., 108: 223-228, 1967.VARGAS, S. Tratamiento actual de la reacción leprosa por talidomida. Dermatologia: rev. mex., 15(3) :142-154, 1971.
WATERS, M.F.R. An internally-controlled double blind trial of thalidomide in severe erythema nodosum leprosum. Lepr. Rev., 42(1):26-42, 1971.
WATERS, M.F.R. Treatment of reactions in leprosy. Lepr. Rev., 46(4) :337-341, 1974.
5. Emprego em outras dermatoses
BARBA RUBIO, J. & FRANCO MARTINEZ, F. Lupus eritematoso fijo: su tratamiento con talidomida. Med. Cut. Iber. Lat. Amer., 5(4) :279-285, 1977.
CALNAN, C.D. & MEARA, R.H. Actinic prurigo (Hutchinson's summer prurigo) Clin. Exp. Dorm., 2:365-372, 1977.
ERAVELLY, J. & WATERS, M.F. Thalidomide in Weber-Christian disease. Lancet, 1(8005):251, 1977.
LONDOSO, F. Thalidomide in the treatment of actinic prurigo. Int. J. Dermat., 12 (5) :326-328, 1973.
MASCARO, J.M.; LECHA, M.; TORRAS, H. Thalidomide in the treatment of recurrent, necrotic and giant
mucocutaneous aphthal and aphtosis. Arch. Dermatol., 115(5): 636-637, 1979.
MATTOS, O. Prurigo nodular de Hyde tratado com talidomida. Bol. Div. Nac. Lepra, 32(1):71-77, 1973.
SANSOEN, M. et al. Thalidomide in the treatment of discoid lupus erythematous (D.L.E.) Ann. Dermatol.
Venereol., 107 (6) :515-523, 1980.
SAUL, A.; FLORES, O.; NOVALES, J. Polymorphus light eruption: treatment with thalidomide. Aust. J. Derm., 17(1) :17-21, 1976.
SHESKIN, J. Zur Therapie des Prurigo nodulaires Hyde mit Thalidomid. Hautartz, 26:215-217, 1975.
BORE, P.J. et al. Effects of thalidomide on survival of skin homographs in rabbits. Lancet, 1:1240-1241, 1966.
BURLEY, D.M. Is thalidomide to blame? Brit. Med. J., 1:130, 1961.
CALVO, R. & MUCKTER, H. Sur le mécanisme d'action de la thalidomide et autres imides cycliques dans la réaction lépreuse. Acta Leprol. (48/49) :27-29, 1972.
CERRUTI, M.P.;BORRONE,C.; TAMBUSSI, A.M. Ricerche sperimentali sull'effetto dell'imide dell'accido Nftalil-glutammico (Talidomide) sulla sintesi degli anticorpi. Risposta all'iniezione di albumina umana. Minerva Pediatr., /5:13921394, 1963.
DUKOR, P. et al. Immunosuppression by thalidomide. Lancet, 1:569-570, 1967.
FABRO, S. et al. The metabolism of thalidomide: some biological effects of thalidomide and its metabolites. Brit. J. Pharmacol., 25:352-362, 1965.
FAIGLE, J.W. The metabolic fate of thalidomide. Experentia, 18(9) :389-397, 1962.
FIELD, E.O. et al. Effect of thalidomide on the graft vs host reaction. Nature, 211: 1308-1310, 1969.
GOIHMAN-YAHR, M. et al. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide in vivo and in vitro. Activation in adjuvant disease. Int. Arch. Allerg. Appl. Immunol., 57(4):317-332, 1978.
GUSDON Jr., J.P. et al. Effect of thalidomide on the antibody response. Amer. J. Obstet. Gynec., 100:952-956, 1968.
HANAUSKE-ABEL, H. & GUNZLER, V. Inhibition of human prolyl hydroxylase as common biochemical denominator of the non-sedative effects of thalidomide in man. Int. J. Lepr., 46:449, 1978.
HASTINGS, R.C. Mechanism of halidomide action in HD. Star, 94 (2) :1,15, 1974.
HELLMANN, K.; DUKE, D.I.; TUCKER, D.F. Prolongation of skin homograft survival by thalidomide. Brit. Med. J., 2 (5463) :687-689, 1965.
KUNS, W.K. & MUCKTER, H. N-Phthalylglutaminsaüreimid. Arzneimittelforsch, 6: 426-430, 1956.
LOCKER, D.; SUPERSTINE, E.; SULMAN, F.G. The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues. Arch. Int. Pharmacodyn. Therm., 194:39-55, 1971.
OGILVIE, J.W. et a1. The effect of thalidomide on the immune response. Fed. Proc., 27:494, 1968.
OLIVEIRA e SILVA, C. et al. Influência da talidomida sobre os linfócitos circulantes na hanseníase virchowiana.
Bol. Div. Nac. Lepra, 29:77-84, 1973.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the fat of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmecol., 25:338-351, 1965.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution. Brit. J. Pharmacol., 25:324-337, 1965.
SHÉSKIN, J. Influencia de la talidomida, esteroides, analgésicos y placebos sobrela velocidad de la conducción motors en la neurites cubital reaccional. Med. Cut., 4(5) :459-464, 1970.
SOMERS, G.F. Pharmacological properties of thalidomide (alfaphthalamide glutarimide) a new sedative hipnotic drug. Brit. J. Pharmacol., 15:111-116, 1960.
SOUZA, L.P. Thalidomide. Brit. Med. J., 2 (5152) :635, 1959.
THOMAS, E.M. et al. Efeito da talidomida sobre os linfócitos e imunoglobulinas G.A e M no sanguesirculante de pessoas normais. Bol. Div. Nac. Dermat. Sanit., 34 (1/4) :73-79, 1975.
TURK, J.L. et al. Effect of thalidomide on the immunological response in local lymph nodes after a skin homograft. Lancet, 1: 1134, 1966.
ULRICH, M.; SALAS, B.; CONVIT, J. Thalidomide activity in experimental arthus and anaphylactic reactions. Int. J.
Lepr., 89(2):131-135, 1971.
WINTER, C.A. Nonsteroid antiinflammatory agents. Ann. Rev. Pharmacol., 6:157-174, 1966.
WOODYATT, P.B. Thalidomide. Lancet, 1: 750, 1962.
3. Efeitos colaterais. Teratogenicidade
BARTHOLOMEW, A.A. Neuropathy after thalidomide. Brit. Med. J., 2(5266) : 15701571, 1961.
BOHM, R. & NITSCH, K. Another chance for thalidomide? Lancet, 1:92, 1966.
BURLEY, D.M. Overdosage with thalidomide. Med. World, 98(1).:26-28, 1960.
CHEVENS, L.C.F. Neuropathy after thalidomide. Brit. Med. J., 2(5258) :1025, 1961.
CHEYMOL, J. Le drame du thalidomide. Rev. Ass. Med. Bras., 11(4) :123-134, 1965.
FIELD, K.W.G.H. Neuropathy after thalidomide. Brit. Med. J., 2:1084, 1961.
FURLLETON, P.M. et al. Neuropathy after intake of thalidomide. Brit. Med. J., 2: 855-858, 1961.
GOIHMAN-YAHR, M. et aI. Autoimmune diseases and thalidomide. I. Experimental allergic encephalomyelitis
and experimental allergic neuritis of the Guinea Pig. Int. J. Lepr., 40(2) :133-141, 1972.
KELSEY, F.O. Events after thalidomide. J. Dent. Res., 46:1201-1205, 1967.KERBELE, H. et al. Biochemical effects of
drugs on the anormalian concepts. Ann. N.Y. Acad. Sei., 123:252-262, 1965.
LENZ, W. Thalidomide and congenital abnormalities. Lancet, 1 :272, 1962.
LENZ, W. Thalidomide and congenital anomalies. Lancet, 1:45, 1962.
McCREDIE, J. & McLEOD, J.G. Thalidomide and embryonic neuropathy. Lancet, 1 (7866) :1111, 1974.
MAGORA, A. et al. Controlled follow-up assessment of the effect of thalidomide upon the ulnar nerve in leprosy. Int. J. Lepr., 89(4) :863-871, 1971.
MELLIN, G.W. & KATZENSTEIN, M. The saga of thalidomide: neuropathy to embryopathy with case reports of
congenital anomalies. N. Engl. J. Med., 267(23): 1184-1193, 1962.
MELLIN, G.W. & KATZENSTEIN, M. The saga of thalidomide: neuropathy to embryopathy with case reports of
congenital anomalies (Concluded) N. Engl. J. Med., 267(24) :1238-1244, 1962.
MENGONI, H.R. et al. Talidomida: droga teratogenica y su indicación en la reacción leprosa: esquema terapêutico. Leprologia, 14(2):194-206, 1969.
MURAD, J.A. Moléculas teratogênicas. Hospital, 72:299, 1967.
ROATH, S.; ELVES, M.W.; ISRAELS, M.C.G. Effects of thalidomida and its derivatives on human leucocytes
cultured in vitro. Lancet, 1(7275) :249-250, 1963.
SABIN, T.D. Thalidomide neuropathy and leprous neuritis. Lancet, 1(7849) :165-166, 1974.
SAGHER, F. & SHESKIN, J. Réaction lépreuse et thalidomide. Etudes imunologiques. Acts Leprol. (48/49):11-26, 1972.
SHANNON, E.J.; MIRANDA, R.O.; HASTINGS, R.C. Inhibition of the novo antibody synthesis by thalidomide. Int. J.
Lepr., 46(1) :120, 1978.
SHESKIN, J. & SAGHER, F. Erupción tipo dermatitis herpetiforme en enfermos del mal de Hansen tratados con talidomida. Rev. Leprol. Fontilles, 7:229, 1968.
TAUSSIG, H.B. A study of the German outbreak of phocomelia. The thalidomide syndrome. JAMA, 180:1106, 1962.
WEMAMBU, S.N.C. et al. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933935, 1969.WOOLLAM, D.H.M. Principles of teratogenesis: mode of action of thalidomide. Proc. Roy. Soc. Med., 68(7) :497-501, 1965.
4. Emprego na reação hansênica
ACEVES ORTEGA, R. Algunos hechos recientes en terapéutica dermatologica. Reacción leprosa y talidomida. Otros usos de Ias sulfonas. Medicina, 61(1119) :530537, 1971.
AITKEN, G. La thalidomide dans les états de réaction lépreux. Paris, 1968. / These/ 135p.
ALMEIDA, R. Considerações sobre o uso da talidomida na reação leprótica. Rovisco Pais: rev. port. doença Hansen, 11(4) : 365-369, 1972.
ARGUELLO PITT, L. et al. Acción de la talidomida en la reacción leprosa. Leprologia, 18(1):18-26, 1973.
BALISA, L.M. et al. La talidomida en los episódios reaccionales de la lepra. Leprologia, 14(2) :189-193, 1969.
BARBOSA, A. & ALMEIDA, B. A talidomida no tratamento da lepro-reação. Rovisco Pais: rev. port. doença Hansen, 8(28): 23-33, 1969.
BELDA, W. A talidomida no controle da dor nas neurites lepróticas. Hospital, 70(3): 231-237, 1966.
CAZORT, R.T. et ah A trial of thalidomide in progressive lepra reaction. Curr. Ther. Res., 8:299-311, 1966.
CONVIT, J.; SOTO, J.M.; SHESKIN, J. Thalidomide therapy in the lepra reaction. Int. J. Lepr., 35(4) :446-451, 1967.
CRAWFORD, C.L. Thalidomide in erythema nodosum leprosum. Lancet, 2(7839):12011202, 1973.
DEGOS, R. et al. Action rapidement résolutive de la thalidomide sur les poussées de la lèpre. Bull. Soc. Franc. Dermat. Syphil., 78(5) :474-478, 1966.
DUPERRAT, B. et al. Hansen L: action de la thalidomide sur une poussée gravissime. Bull. Soc. Franc. Dermat. Syphil., 78(3) : 291-292, 1971.
EMPLEO de la talidomida en la reacción leprosa. Salud Publ. Mex., 18 (4) :777-779, 1976.
GAY PRIETO, J. Tratamiento de Ias reacciones leprosas con talidomida. Med. Cut., 2:117, 1967.
GONZALEZ-BENAVIDEZ, J. & HERNANDEZ, G.E. Talidomida y reacción leprosa. In: CONGRESO MEXICANO DE
DERMATOLOGIA, 5, México, 1969. Memórias. México, 1970. p. 471-475.
HASTINGS, R.C. et al. Thalidomide in treatment of erythema nodosum leprosum. Clin. Pharm. Ther., 11(4) :481-487, 1970.
ISLA CARANDE, E. Lepra y talidomida. Actas Dermosifiliogr., 99(3/4) :139-200, 1968.
IYER, C.G.S. et al. WHO co-ordinated shortterm double-blind trial with thalidomide in the treatment of acute
lepra reactions in male lepromatous patients. Bull. WHO, 46(6):719-732, 1971.
KHRIKOU, N.A. Results of treatment of leprosy patients with thalidomide. Sci. Works Lepr. Res. Inst., 9/14:88-90,
1976.
KLUKEN, N. & WENTE, W. Indications for thalidomide therapy for leprosy. Int. J. Dermatol., 13 (1) :20-25, 1974.
LANGUILLON, J. Action de deux nouveaux produits: la thalidomide et le B.663 sur les formes réactionnelles de la maladie de Hansen. C.R. Inst. Marchoux, 10(2): 34-41, 1969.
LANGUILLON, J. Action de la thalidomide sur la réaction lépreuse. Acts Leprol., (40/41) :51-55, 1970.
LANGUILLON, J. The effects of thalidomide on leprosy reaction. Int. J. Lepr., 39 (2): 590-592, 1971.
LA ROSA, P. & CASCIANO, A. Reazioni lebbrose e talidomide. Minerva Dermat., 48(4) :166-168, 1968.
LATAPI, F.; SAÚL, A.; GÓMEZ-VIDAL, M. Talidomida en el tratamiento de la reacción leprosa: tres anos de experiencia en México. Gac. Med. Mere., 99(10) :917-930, 1969.
LAVALLE, P. Comentário oficial /Talidomida en el tratamiento de la reacción leprosa/Gac. Med. Mex., 99(10):930-
931, 1969.
LEVY, L. et al. Treatment of erythema nodosum leprosum with thalidomide. Lancet, 2 (7824) :324-325, 1973.
LOVIO CARDE13AS, Z. et al. Empleo de la talidomida en la reacción leprosa. Estudio en la provincia de la Habana. Bol. Hig. Epid., 12(2) :141-146, 1974.
MAGORA, A.; SHESKIN, J.; SAGHER, F. Motor conduction velocity test of the ulnar nerve in leprosy reaction underthalidomide therapy. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4) : 624, 1968.
MARQUES, B. & OPROMOLLA, D.V.A. Thalidomide in treatment of lepra reaction. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4) :637, 1968.
MATTOS, O. & ALONSO, A.M. Treatment of leprosy reaction with thalidomide. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4):642-643, 1968.
MELAMED, J. Acción de la talidomida en el tratamiento de la reacción leprosa. Rev. Argent. Derm., 58(7): — , 1969.
MERKLEN, F.P. et al. Deuce eas d'ineficacité antireactionelle de la thalidomide dans la lèpre. Bull. Soc. Franç. Derm. Syphiligr., 75:638, 1968.
MOHR, W. Thalidomide in leprosy therapy. Int. J. Lepr., 39(2):598-599, 1971.
NETTO, L.S. Talidomida nas reações lepróticas. Rev. Bras. Med., 24 (9) :760-763, 1967.
OCAMPO, J.C.; GATTI, J.C.; CARDAMA, J.E. Tratamiento de la lepra en reacción. Rev. Leprol. Fontilles, 10(3):269-280, 1975.
OPROMOLLA, D.V.A.; LIMA, L.S.; MARQUES, M.B. A talidomida nos surtos agudos de lepra: eritema nodoso ou polimorfo. Hospital, 69(4) :191-208, 1966.
OSSWALD, W. Reacção leprosa e talidomida. Rovisco Pais: rev. port. doença Hansen, 7(24) :34-36, 1968.
PEARSON, J.M.H. & VEDAGIRI, M. Treatment of moderately senere erythema nodosum leprosum with thalidomide — A double blind controlled trial. Lepr. Rev., 40(2) :111-116, 1969.
PETTIT, J.H.S. & WATERS, M.F.R. The etiology of erythema nodosum leprosum. Int. J. Lepr., 35 (1) :1-10, 1967.
RODRIGUEZ, E.; RAMIREZ, J.; YAMBAY, J. Talidomida en reacción leprosa. Dermatologia: rev. mex.,13 (2) :147-151, 1969.
SAMPAIO, S.A.P. & PROENÇA, N. Tratamento da reação leprótica pela talidomida. Rev. Paul. Med., 68:301, 1966.
SAY)L, A. Reacción leprosa y talidomida: resultados del tratamiento de 30 casos. Prensa Med. Mex., 34(11/12) :403-409, 1969.
SAÚL, A. Talidomida en el tratamiento dela reacción leprosa. Primeras observaciones en México. Medicina: rev.
mex., 47: 348-353, 1965.
SAIYL, A. Talidomidodependencia y talidomidorresistencia. Leprologia, 19(2):253-260, 1974.
SHESKIN, J. Fifty month's use of thalidomide in leprosy reaction. Star, 28(6) :3, 1969.
SHESKIN, J. Further observation with thalidomide in lepra reaction. Lepr. Rev., 86(4):183-185, 1965.
SHESKIN, J. Incorporación de la talidomida al arsenal terapéutico del mal de Hansen. Actas Dermosifiliogr., 60 (3/4) :57-72, 1969.
SHESKIN, J. Influencia de la talidomida en la reacción leprosa. Derm. Venez., 4 (3/4) :210-221, 1964/1965.
SHESKIN, J. Recent experience with thalidomide in Hansen's disease. Int. J. Dermat., 9 (1) :56-58, 1970.
SHESKIN, J. Study with nine thalidomide derivatives in lepra reaction. Int. J. Dermat., 17:82-84, 1978.
SHESKIN, J. Thalidomide in lepra reaction. Int. J. Dermat., 14(8) :575-576, 1976.
SHESKIN, J. Thalidomide in the treatment of lepra reactions. Clin. Pharmacol. Ther., 6(3) :303-306, 1965.
SHESKIN, J. The treatment of lepra reaction in lepromatous leprosy. Fifteen years experience with thalidomide. Int. J. Der- mat., 19(6) :318-322, 1980.
SHESKIN, J. & CONVIT, J. Results of a double-blind study of the influence of thalidomide on the lepra reaction. Int. J. Lepr., 87(2) :135-146, 1969.
SHESKIN, J. & CONVIT, J. Therapy of the lepra reaction with thalidomide. A double-blind study. Hautarzt, 17:548-549, 1965.
SHESKIN, J. & SAGHER, F. Encuesta mundial sobre el use de la talidomida en la leprorreacción. Med. Cut. Iber. Lat. Amer., 8 (1) :81-83, 1975.
SHESKIN, J. & SAGHER, F. Five year's experience with thalidomide treatment in leprosy reaction. Int. J. Lepr., 89 (2) : 585-588, 1971.
SHESKIN, J. & SAGHER, F. The present status of thalidomide treatment in lepra reaction on leprosy. In: INTERNATIONAL LEPROSY CONGRESS, 9, London,1968. Transactions. Int. J. Lepr., 86(4) : 637, 1968.
SHESKIN, J. & SAGHER, F. Trials with thalidomide derivatives in leprosy reactions. Lepr. Rev., 89(4) :203-206, 1968.
SHESKIN, J. & ZAUBERMAN, H. Iridocyclitis in lepra reaction treated with thalidomide. Lepr. Rev., 41(4) :233-236,
1970.
SHESKIN, J. et al. Unsatisfactory results with thalidomide as a specific treatment for leprosy. J. Med. Sci., 4:901-907, 1968.
SWIFT, T.R. Thalidomide in erythema nodosum leprosum. Lancet, 2(7835) :966, 1973.
TARABINI-CASTELLANI, G. Tratamiento de las leprorreacciones con talidomida. Rev. Leprol. Fontilles, 6(8) :719-723, 1967.
TERENCIO DE LAS AGUAS, J. Seis anos de experiencia con talidomida. Rev. Leprol. Fontilles, 8(5) :587-598, 1972.
TERENCIO DE LAS AGUAS, J. Thalidomide in the treatment of lepra reactions. Int. J. Lepr., 39 (2) :593-597, 1971.
TERENCIO DE LAS AGUAS, J. & CONTRERAS DUES AS, F. Primeros resultados del tratamiento de las leprorreacciones con talidomida. Rev. Leprol. Fontilles,
6(5) :449-455, 1966.
TERENCIO DE LAS AGUAS, J. & CONTRERAS DUERAS, F. Tratamiento de las leprorreacciones con talidomida.
Rev. Leprol. Fontilles, 7(1) :1-21, 1968.
TERENCIO DE LAS AGUAS, J. & ROSTOLL, F. Thalidomide in treatment of leprous reactions. In: INTERNATIONAL LEPROSY CONGRESS, 9, London, 1968. Transactions. Int. J. Lepr., 86(4): 644, 1968.
TRIMIGLIOZZI, G. La thalidomide nelle "reazioni" lebbrose. Gior. Ital. Dermat., 107:1353-1365, 1966.
TRIMIGLIOZZI, G. Ulteriori osservazioni sull'imprego della thalidomide nelle "reazioni" lebbrose. Gior. Ital. Dermat., 108: 223-228, 1967.VARGAS, S. Tratamiento actual de la reacción leprosa por talidomida. Dermatologia: rev. mex., 15(3) :142-154, 1971.
WATERS, M.F.R. An internally-controlled double blind trial of thalidomide in severe erythema nodosum leprosum. Lepr. Rev., 42(1):26-42, 1971.
WATERS, M.F.R. Treatment of reactions in leprosy. Lepr. Rev., 46(4) :337-341, 1974.
5. Emprego em outras dermatoses
BARBA RUBIO, J. & FRANCO MARTINEZ, F. Lupus eritematoso fijo: su tratamiento con talidomida. Med. Cut. Iber. Lat. Amer., 5(4) :279-285, 1977.
CALNAN, C.D. & MEARA, R.H. Actinic prurigo (Hutchinson's summer prurigo) Clin. Exp. Dorm., 2:365-372, 1977.
ERAVELLY, J. & WATERS, M.F. Thalidomide in Weber-Christian disease. Lancet, 1(8005):251, 1977.
LONDOSO, F. Thalidomide in the treatment of actinic prurigo. Int. J. Dermat., 12 (5) :326-328, 1973.
MASCARO, J.M.; LECHA, M.; TORRAS, H. Thalidomide in the treatment of recurrent, necrotic and giant
mucocutaneous aphthal and aphtosis. Arch. Dermatol., 115(5): 636-637, 1979.
MATTOS, O. Prurigo nodular de Hyde tratado com talidomida. Bol. Div. Nac. Lepra, 32(1):71-77, 1973.
SANSOEN, M. et al. Thalidomide in the treatment of discoid lupus erythematous (D.L.E.) Ann. Dermatol.
Venereol., 107 (6) :515-523, 1980.
SAUL, A.; FLORES, O.; NOVALES, J. Polymorphus light eruption: treatment with thalidomide. Aust. J. Derm., 17(1) :17-21, 1976.
SHESKIN, J. Zur Therapie des Prurigo nodulaires Hyde mit Thalidomid. Hautartz, 26:215-217, 1975.
Downloads
Publicado
30-11-1981
Como Citar
1.
Santos Junior. MFQ dos, Lombardi C, Belda W. Talidomida: uma revisão de literatura. Hansen. Int. [Internet]. 30º de novembro de 1981 [citado 26º de abril de 2024];6(2):136-45. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36117
Edição
Seção
Artigos originais
Licença
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Este periódico está licenciado sob uma Creative Commons Attribution 4.0 International License.
