Palavras-chave
Hanseníase
Reação Hansênica
Talidomida
Terapêutica
Reação Hansênica
Talidomida
Terapêutica
Como Citar
1.
Santos Junior. MFQ dos, Lombardi C, Belda W. Talidomida: uma revisão de literatura. Hansen. Int. [Internet]. 30º de novembro de 1981 [citado 23º de novembro de 2024];6(2):136-45. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36117
Resumo
Procedeu-se a uma revisão bibliográfica extensiva sobre a talidomida, em seus aspectos farmacológicos, metabólicos, teratogenicidade e especialmente quanto às suas aplicações terapêuticas em Dermatologia, destacando-se o uso na reação hansênica.
Referências
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BORE, P.J. et al. Effects of thalidomide on survival of skin homographs in rabbits. Lancet, 1:1240-1241, 1966.
BURLEY, D.M. Is thalidomide to blame? Brit. Med. J., 1:130, 1961.
CALVO, R. & MUCKTER, H. Sur le mécanisme d'action de la thalidomide et autres imides cycliques dans la réaction lépreuse. Acta Leprol. (48/49) :27-29, 1972.
CERRUTI, M.P.;BORRONE,C.; TAMBUSSI, A.M. Ricerche sperimentali sull'effetto dell'imide dell'accido Nftalil-glutammico (Talidomide) sulla sintesi degli anticorpi. Risposta all'iniezione di albumina umana. Minerva Pediatr., /5:13921394, 1963.
DUKOR, P. et al. Immunosuppression by thalidomide. Lancet, 1:569-570, 1967.
FABRO, S. et al. The metabolism of thalidomide: some biological effects of thalidomide and its metabolites. Brit. J. Pharmacol., 25:352-362, 1965.
FAIGLE, J.W. The metabolic fate of thalidomide. Experentia, 18(9) :389-397, 1962.
FIELD, E.O. et al. Effect of thalidomide on the graft vs host reaction. Nature, 211: 1308-1310, 1969.
GOIHMAN-YAHR, M. et al. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide in vivo and in vitro. Activation in adjuvant disease. Int. Arch. Allerg. Appl. Immunol., 57(4):317-332, 1978.
GUSDON Jr., J.P. et al. Effect of thalidomide on the antibody response. Amer. J. Obstet. Gynec., 100:952-956, 1968.
HANAUSKE-ABEL, H. & GUNZLER, V. Inhibition of human prolyl hydroxylase as common biochemical denominator of the non-sedative effects of thalidomide in man. Int. J. Lepr., 46:449, 1978.
HASTINGS, R.C. Mechanism of halidomide action in HD. Star, 94 (2) :1,15, 1974.
HELLMANN, K.; DUKE, D.I.; TUCKER, D.F. Prolongation of skin homograft survival by thalidomide. Brit. Med. J., 2 (5463) :687-689, 1965.
KUNS, W.K. & MUCKTER, H. N-Phthalylglutaminsaüreimid. Arzneimittelforsch, 6: 426-430, 1956.
LOCKER, D.; SUPERSTINE, E.; SULMAN, F.G. The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues. Arch. Int. Pharmacodyn. Therm., 194:39-55, 1971.
OGILVIE, J.W. et a1. The effect of thalidomide on the immune response. Fed. Proc., 27:494, 1968.
OLIVEIRA e SILVA, C. et al. Influência da talidomida sobre os linfócitos circulantes na hanseníase virchowiana.
Bol. Div. Nac. Lepra, 29:77-84, 1973.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the fat of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmecol., 25:338-351, 1965.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution. Brit. J. Pharmacol., 25:324-337, 1965.
SHÉSKIN, J. Influencia de la talidomida, esteroides, analgésicos y placebos sobrela velocidad de la conducción motors en la neurites cubital reaccional. Med. Cut., 4(5) :459-464, 1970.
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3. Efeitos colaterais. Teratogenicidade
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4. Emprego na reação hansênica
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WATERS, M.F.R. An internally-controlled double blind trial of thalidomide in severe erythema nodosum leprosum. Lepr. Rev., 42(1):26-42, 1971.
WATERS, M.F.R. Treatment of reactions in leprosy. Lepr. Rev., 46(4) :337-341, 1974.
5. Emprego em outras dermatoses
BARBA RUBIO, J. & FRANCO MARTINEZ, F. Lupus eritematoso fijo: su tratamiento con talidomida. Med. Cut. Iber. Lat. Amer., 5(4) :279-285, 1977.
CALNAN, C.D. & MEARA, R.H. Actinic prurigo (Hutchinson's summer prurigo) Clin. Exp. Dorm., 2:365-372, 1977.
ERAVELLY, J. & WATERS, M.F. Thalidomide in Weber-Christian disease. Lancet, 1(8005):251, 1977.
LONDOSO, F. Thalidomide in the treatment of actinic prurigo. Int. J. Dermat., 12 (5) :326-328, 1973.
MASCARO, J.M.; LECHA, M.; TORRAS, H. Thalidomide in the treatment of recurrent, necrotic and giant
mucocutaneous aphthal and aphtosis. Arch. Dermatol., 115(5): 636-637, 1979.
MATTOS, O. Prurigo nodular de Hyde tratado com talidomida. Bol. Div. Nac. Lepra, 32(1):71-77, 1973.
SANSOEN, M. et al. Thalidomide in the treatment of discoid lupus erythematous (D.L.E.) Ann. Dermatol.
Venereol., 107 (6) :515-523, 1980.
SAUL, A.; FLORES, O.; NOVALES, J. Polymorphus light eruption: treatment with thalidomide. Aust. J. Derm., 17(1) :17-21, 1976.
SHESKIN, J. Zur Therapie des Prurigo nodulaires Hyde mit Thalidomid. Hautartz, 26:215-217, 1975.
BORE, P.J. et al. Effects of thalidomide on survival of skin homographs in rabbits. Lancet, 1:1240-1241, 1966.
BURLEY, D.M. Is thalidomide to blame? Brit. Med. J., 1:130, 1961.
CALVO, R. & MUCKTER, H. Sur le mécanisme d'action de la thalidomide et autres imides cycliques dans la réaction lépreuse. Acta Leprol. (48/49) :27-29, 1972.
CERRUTI, M.P.;BORRONE,C.; TAMBUSSI, A.M. Ricerche sperimentali sull'effetto dell'imide dell'accido Nftalil-glutammico (Talidomide) sulla sintesi degli anticorpi. Risposta all'iniezione di albumina umana. Minerva Pediatr., /5:13921394, 1963.
DUKOR, P. et al. Immunosuppression by thalidomide. Lancet, 1:569-570, 1967.
FABRO, S. et al. The metabolism of thalidomide: some biological effects of thalidomide and its metabolites. Brit. J. Pharmacol., 25:352-362, 1965.
FAIGLE, J.W. The metabolic fate of thalidomide. Experentia, 18(9) :389-397, 1962.
FIELD, E.O. et al. Effect of thalidomide on the graft vs host reaction. Nature, 211: 1308-1310, 1969.
GOIHMAN-YAHR, M. et al. Significance of neutrophil activation in reactional lepromatous leprosy: effects of thalidomide in vivo and in vitro. Activation in adjuvant disease. Int. Arch. Allerg. Appl. Immunol., 57(4):317-332, 1978.
GUSDON Jr., J.P. et al. Effect of thalidomide on the antibody response. Amer. J. Obstet. Gynec., 100:952-956, 1968.
HANAUSKE-ABEL, H. & GUNZLER, V. Inhibition of human prolyl hydroxylase as common biochemical denominator of the non-sedative effects of thalidomide in man. Int. J. Lepr., 46:449, 1978.
HASTINGS, R.C. Mechanism of halidomide action in HD. Star, 94 (2) :1,15, 1974.
HELLMANN, K.; DUKE, D.I.; TUCKER, D.F. Prolongation of skin homograft survival by thalidomide. Brit. Med. J., 2 (5463) :687-689, 1965.
KUNS, W.K. & MUCKTER, H. N-Phthalylglutaminsaüreimid. Arzneimittelforsch, 6: 426-430, 1956.
LOCKER, D.; SUPERSTINE, E.; SULMAN, F.G. The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues. Arch. Int. Pharmacodyn. Therm., 194:39-55, 1971.
OGILVIE, J.W. et a1. The effect of thalidomide on the immune response. Fed. Proc., 27:494, 1968.
OLIVEIRA e SILVA, C. et al. Influência da talidomida sobre os linfócitos circulantes na hanseníase virchowiana.
Bol. Div. Nac. Lepra, 29:77-84, 1973.
SCHUMACHER, H.; SMITH, R.L.; WILLIAMS, R.T. The metabolism of thalidomide: the fat of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmecol., 25:338-351, 1965.
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3. Efeitos colaterais. Teratogenicidade
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4. Emprego na reação hansênica
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5. Emprego em outras dermatoses
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