Palavras-chave
cavidade bucal
hanseníase
M. leprae
hanseníase
M. leprae
Como Citar
1.
Costa MRSN. Considerações sobre o envolvimento da cavidade bucal na hanseníase. Hansen. Int. [Internet]. 30º de junho de 2008 [citado 16º de novembro de 2024];33(1):41-4. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36249
Resumo
As lesões causadas pela proliferação do Mycobacterium leprae (M. leprae) foram significantemente reduzidas nos últimos anos com a detecção precoce de casos novos. Consequentemente, as lesões maxilofaciais e da mucosa bucal passaram ser cada vez menos relatadas. A despeito de ser menos evidente, a infecção da cavidade bucal pelo M. leprae pode revelar detalhes importantes a respeito da transmissibilidade e imunopatogenia da hanseníase. A associação entre a infecção da mucosa bucal e a perda óssea alveolar, bem como a participação da resposta imune local na proteção contra a doença, ainda são tópicos de pesquisa não explorados totalmente. Infelizmente, o tratamento da hanseníase não possibilitou a prevenção total de suas seqüelas, nem impediu transmissão dessa doença. As razões acima justificam rever algumas perguntas não respondidas do passado.
Referências
1 Ridley DS, Jopling WH. A classification of leprosy for research purposes. Lepr Rev 1962 Apr; (33):119-28.
2 Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 1966 Jul-Sep; 34(3):255-73.
3 World Health Organization (WHO). Chemotherapy of leprosy for control programmes. WHO Technical Report Series, n. 675. Geneva: World Health Organization; 1982.
4 Pardillo FE, Fajardo TT, Abalos RM, Scollard D, Gelber RH. Methods for the classification of leprosy for treatment purposes. Clin Infect Dis 2007 Apr 15; 44(8): 1096-9.
5 Costa A, Nery J, Oliveira M, Cuzzi T, Silva M. Oral lesions in leprosy. Indian J Dermatol Venereol Leprol 2003 Nov-Dec; 69(6): 381-5.
6 Opromolla DVO, Opromolla MA, Ura S. Lesões dimorfas na cavidade oral. Hansen. int. 2003; 28(2):151-5.
7 Abreu MA, Michalany NS, Weckx LL, Neto Pimentel DR, Hirata CH, Avelar Alchorne MM. The oral mucosa in leprosy: a clinical and histopathological study. Rev Bras Otorrinolaringol (Engl Ed). 2006 May-Jun;72(3):312-6.
8 Martins MD, Russo MP, Lemos JB, Fernandes KP, Bussadori SK, Corrêa CT, et al. Orofacial lesions in treated southeast Brazilian leprosy patients: a cross-sectional study. Oral Dis 2007 May; 13(3):270-3.
9 Abreu MA, Alchorne MM, Michalany NS, Weckx LL, Pimentel DR, Hirata CH. The oral mucosa in paucibacillary leprosy: a clinical and histopathological study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May; 103(5):e48-52. Epub 2007 Jan 12.
10 Santos GG, Marcucci G, Guimarães JJ, Margarido LC, Lopes LHC. Pesquisa de Mycobacterium leprae em biópsias de mucosa oral por meio da reação em cadeia da polimerase. An Bras Dermatol 2007; 82(3): 245-9.
11 Cree IA, Smith WC. Leprosy transmission and mucosal immunity: Towards eradication? Lepr Rev 1998; (69):112-21.
12 Ramaprasad P, Fernando A, Madhale S, Rao JR, Edward VK, Samson PD, et al. Transmission and protection in leprosy: indications of the role of mucosal immunity. Lepr Rev 1997 Dec; 68(4):301-15.
13 Nagao-Dias AT, Almeida TL, Oliveira MF, Santos RC, Lima AL, Brasil M. Salivary anti-PGL IgM and IgA titers and serum antibody IgG titers and avidities in leprosy patients and their correlation with time of infection and antigen exposure. Braz J Infect Dis 2007 Apr; 11(2):215-9.
14 Smith WC, Smith CM, Cree IA, Jadhav RS, Macdonald M, Edward VK et al. An approach to understanding the transmission of Mycobacterium leprae using molecular and immunological methods: results from the MILEP2 study. Int J Lepr Other Mycobact Dis 2004 Sep; 72(3):269-77.
15 Truman RW, Krahenbuhl JL. Viable M. leprae as a research reagent. Int J Lepr. Other Mycobact. Dis 2001; (69):1-12.
16 Scheepers A. Correlation of oral surface temperatures and the lesions of leprosy. Int J Lepr Other Mycobact Dis 1998 Jun; 66(2):214-7.
17 Scollard DM, Skinsnes OK. Oropharyngeal leprosy in art, history, and medicine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Apr; 87(4):463-70.
18 Jesudasan S, John SP, Jesudasan K, Christian M, Fritschi EP. An analysis into the trends of reconstructive surgery in Gudiyatham Taluk, a leprosy control area. Lepr India 1981 Apr;53(2):213-20.
19 Reichart PA, Srisuwan S, Metah D. Lesions of the facial and trigeminal nerve in leprosy. An evaluation of 43 cases. Int J Oral Surg 1982 Feb;11(1):14-20.
20 Christensen VM, Bakke SN, Melson RS, Waaler E. Changes in the anterior nasal spine and the alveolar process of the maxillary bone in leprosy. Int J Lepr 1952 Jul-Sep; 20(3):335-40.
21 Freitas JA, Santos WM. Facial bone changes in Virchowian Hansen’s disease. Hansen. Int. 1986 Jan-Dec; 11(1-2): 24-43.
22 Subramaniam K, Nah SH, Marks SC. A longitudinal study of alveolar bone loss around maxillary central incisors in patients with leprosy in Malaysia. Lepr Rev 1994 Jun; 65(2):137-42.
23 Marks SC Jr, Grossetete G. Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. Int J Lepr Other Mycobact Dis 1988 Mar; 56(1):21-6.
2 Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 1966 Jul-Sep; 34(3):255-73.
3 World Health Organization (WHO). Chemotherapy of leprosy for control programmes. WHO Technical Report Series, n. 675. Geneva: World Health Organization; 1982.
4 Pardillo FE, Fajardo TT, Abalos RM, Scollard D, Gelber RH. Methods for the classification of leprosy for treatment purposes. Clin Infect Dis 2007 Apr 15; 44(8): 1096-9.
5 Costa A, Nery J, Oliveira M, Cuzzi T, Silva M. Oral lesions in leprosy. Indian J Dermatol Venereol Leprol 2003 Nov-Dec; 69(6): 381-5.
6 Opromolla DVO, Opromolla MA, Ura S. Lesões dimorfas na cavidade oral. Hansen. int. 2003; 28(2):151-5.
7 Abreu MA, Michalany NS, Weckx LL, Neto Pimentel DR, Hirata CH, Avelar Alchorne MM. The oral mucosa in leprosy: a clinical and histopathological study. Rev Bras Otorrinolaringol (Engl Ed). 2006 May-Jun;72(3):312-6.
8 Martins MD, Russo MP, Lemos JB, Fernandes KP, Bussadori SK, Corrêa CT, et al. Orofacial lesions in treated southeast Brazilian leprosy patients: a cross-sectional study. Oral Dis 2007 May; 13(3):270-3.
9 Abreu MA, Alchorne MM, Michalany NS, Weckx LL, Pimentel DR, Hirata CH. The oral mucosa in paucibacillary leprosy: a clinical and histopathological study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May; 103(5):e48-52. Epub 2007 Jan 12.
10 Santos GG, Marcucci G, Guimarães JJ, Margarido LC, Lopes LHC. Pesquisa de Mycobacterium leprae em biópsias de mucosa oral por meio da reação em cadeia da polimerase. An Bras Dermatol 2007; 82(3): 245-9.
11 Cree IA, Smith WC. Leprosy transmission and mucosal immunity: Towards eradication? Lepr Rev 1998; (69):112-21.
12 Ramaprasad P, Fernando A, Madhale S, Rao JR, Edward VK, Samson PD, et al. Transmission and protection in leprosy: indications of the role of mucosal immunity. Lepr Rev 1997 Dec; 68(4):301-15.
13 Nagao-Dias AT, Almeida TL, Oliveira MF, Santos RC, Lima AL, Brasil M. Salivary anti-PGL IgM and IgA titers and serum antibody IgG titers and avidities in leprosy patients and their correlation with time of infection and antigen exposure. Braz J Infect Dis 2007 Apr; 11(2):215-9.
14 Smith WC, Smith CM, Cree IA, Jadhav RS, Macdonald M, Edward VK et al. An approach to understanding the transmission of Mycobacterium leprae using molecular and immunological methods: results from the MILEP2 study. Int J Lepr Other Mycobact Dis 2004 Sep; 72(3):269-77.
15 Truman RW, Krahenbuhl JL. Viable M. leprae as a research reagent. Int J Lepr. Other Mycobact. Dis 2001; (69):1-12.
16 Scheepers A. Correlation of oral surface temperatures and the lesions of leprosy. Int J Lepr Other Mycobact Dis 1998 Jun; 66(2):214-7.
17 Scollard DM, Skinsnes OK. Oropharyngeal leprosy in art, history, and medicine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 Apr; 87(4):463-70.
18 Jesudasan S, John SP, Jesudasan K, Christian M, Fritschi EP. An analysis into the trends of reconstructive surgery in Gudiyatham Taluk, a leprosy control area. Lepr India 1981 Apr;53(2):213-20.
19 Reichart PA, Srisuwan S, Metah D. Lesions of the facial and trigeminal nerve in leprosy. An evaluation of 43 cases. Int J Oral Surg 1982 Feb;11(1):14-20.
20 Christensen VM, Bakke SN, Melson RS, Waaler E. Changes in the anterior nasal spine and the alveolar process of the maxillary bone in leprosy. Int J Lepr 1952 Jul-Sep; 20(3):335-40.
21 Freitas JA, Santos WM. Facial bone changes in Virchowian Hansen’s disease. Hansen. Int. 1986 Jan-Dec; 11(1-2): 24-43.
22 Subramaniam K, Nah SH, Marks SC. A longitudinal study of alveolar bone loss around maxillary central incisors in patients with leprosy in Malaysia. Lepr Rev 1994 Jun; 65(2):137-42.
23 Marks SC Jr, Grossetete G. Facies leprosa: resorption of maxillary anterior alveolar bone and the anterior nasal spine in patients with lepromatous leprosy in Mali. Int J Lepr Other Mycobact Dis 1988 Mar; 56(1):21-6.
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