Influence of testosterone on macrophages activity cocultured with Trichophyton mentagrophytes.
DOI:
https://doi.org/10.47878/hi.2008.v33.35172Keywords:
Trichophyton mentagrophyte, macrophage, testosteronAbstract
The aim of this study was to evaluating the influence of male sexual hormone on activity of Swiss mice resident macrophages cocultured with Trichophyton mentagrophytes. In assayed conditions, testosterone influenced H2O2 release, leading to inhibition of killed macrophage activity in ingested conidia, facilitating its growth and differentiation inside macrophage.
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References
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10 Ahmadi K, Mccruden AB. Macrophage may responses to androgen via its receptor. Med Sci Monit 2006; 12(1):15-20.
11 Fried LR; Bruner M, Moeslinger T, Spieckermann PG. Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages. Life Sci 2000; 62(4):417-29.
12 Segal BH. Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist 2007; 12(Suppl 2):7-13
13 Chinelli PAV, Sofiatti AA, Nunes RS, Martins JE. Dermatophyte agents in the city of Sao Paulo, from 1992 to 2002. Rev Inst Med Trop Sao Paulo 2003;45(5): 259-63.
14 Fernandes NC, Akiti T, Barreiros MGC. Dermatophytoses in children: study of 137 cases. Rev Inst Med Trop Sao Paulo 2001; 43(2):83-85.
15 Gupta AK, Jain, HC, Lynde CW, Watteel GN, Summerbell RC. Prevalence and epidemiology of unsuspected onycomycosis in patient visiting dermatologists’ offices in Ontario, Canada – a multicenter of 2001 patients. Int J Dermatol 1997; 36(10):783-7.
16 Silva-Tavares H, Alchorne MM, Fischman O. Tinea cruris epidemiology (Sao Paulo, Brazil). Mycopathologia 2001; 149(3):147-9.
17 Araujo AJG, Souza MAJ, Bastos OMP, Souza MAJ, Oliveira JC. Occurrence of onychomycosis among patients attended in
dermatology offices in the city of Rio de Janeiro, Brazil. An Bras Dermatol 2003;78(3): 299-308.
18 Moraes MS, Godoy-Martinez, P, Alchorne, MM, Boatto HF, Fischaman, O. Incidence of Tinea capitis in Sao Paulo, Brazil.
Mycopathologia 2006; 162(2):91-5.
19 Vilani-Moreno FR, Arruda MSP, Escudero H. Candidíase Experimental: estudo comparativo de dois Métodos de coloração vital na determinação da viabilidade dos fungos em suspensão. Salusvita 1999; 18(1):139-42.
20 Russo M, Teixeira, HC, Marcondes MC, Barbuto JA. Superoxide-independent hydrogen peroxide release by activated macrophages. Braz J Med Biol Res 1989; 22(10):1271-3.
21 Norman GR, Streiner DL. Biostatistics - The Bare Essentials. Hamilton. Canadian: B.C. Decker Inc; 1998. 260 p.
2 Kobayashi M, Ishida E, Yasuda H, Yamamoto O, Tokura Y. Tinea profunda cysticum caused by Trichophyton rubrum. J Am Acad Dermatol 2006; 54(2 Suppl):S11-3.
3 Evans EGV. Causative pathogens in onychomycosis and the possibility of treatment resistance: a review. J Am Acad Dermatol 1998; 38(5 Pt 3):S32-S56.
4 Murray PR, Drew WL, Korbay JGS. Superficial, Cutaneous, an Subcutaneous Mycosis. In: Murray PR, Rosenthal KS, Kobayashi G, Pfaller MA. Microbiology Medical. 3 ed. St. Louis: Mosby Co; 1997. p.566-76
5 Bocca AL, Brito PP, Figueiredo F, Tosta CE. Inhibition of nitric oxide production by macrophages in chromoblastomycosis: a role for Fonsecaea pedrosoi melanin. Mycopathologia 2006;161(4): 195-203.
5 Campos MRM, Russo M, Gomes E, Almeida SR. Stimulation, inhibition and death of macrophage infected with Trichophyton rubrum. Microbes and Infect 2005;8(2): 372-9.
6 Miller L, Hunt JS. Sex steroid hormones and macrophage function. Life Sci 1996; 59(1):1-14.
7 Cutolo M, Capelino S, Montagna P, Ghiorzo p, Sulli a, Villaggio b. Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line. Arthrits Res Ther 2005; 7(5):R1124-32.
8 Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update. 2005;11(4): 411-23.
9 Weinstein Y, Berkovich Z. Testosterone effect on bone marrow, thymus, and suppressor T cells in the (NZB 3 NZW) F1 mice: its relevance to autoimmunity. J Immunol 1981; 126(3):998-1002.
10 Ahmadi K, Mccruden AB. Macrophage may responses to androgen via its receptor. Med Sci Monit 2006; 12(1):15-20.
11 Fried LR; Bruner M, Moeslinger T, Spieckermann PG. Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages. Life Sci 2000; 62(4):417-29.
12 Segal BH. Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist 2007; 12(Suppl 2):7-13
13 Chinelli PAV, Sofiatti AA, Nunes RS, Martins JE. Dermatophyte agents in the city of Sao Paulo, from 1992 to 2002. Rev Inst Med Trop Sao Paulo 2003;45(5): 259-63.
14 Fernandes NC, Akiti T, Barreiros MGC. Dermatophytoses in children: study of 137 cases. Rev Inst Med Trop Sao Paulo 2001; 43(2):83-85.
15 Gupta AK, Jain, HC, Lynde CW, Watteel GN, Summerbell RC. Prevalence and epidemiology of unsuspected onycomycosis in patient visiting dermatologists’ offices in Ontario, Canada – a multicenter of 2001 patients. Int J Dermatol 1997; 36(10):783-7.
16 Silva-Tavares H, Alchorne MM, Fischman O. Tinea cruris epidemiology (Sao Paulo, Brazil). Mycopathologia 2001; 149(3):147-9.
17 Araujo AJG, Souza MAJ, Bastos OMP, Souza MAJ, Oliveira JC. Occurrence of onychomycosis among patients attended in
dermatology offices in the city of Rio de Janeiro, Brazil. An Bras Dermatol 2003;78(3): 299-308.
18 Moraes MS, Godoy-Martinez, P, Alchorne, MM, Boatto HF, Fischaman, O. Incidence of Tinea capitis in Sao Paulo, Brazil.
Mycopathologia 2006; 162(2):91-5.
19 Vilani-Moreno FR, Arruda MSP, Escudero H. Candidíase Experimental: estudo comparativo de dois Métodos de coloração vital na determinação da viabilidade dos fungos em suspensão. Salusvita 1999; 18(1):139-42.
20 Russo M, Teixeira, HC, Marcondes MC, Barbuto JA. Superoxide-independent hydrogen peroxide release by activated macrophages. Braz J Med Biol Res 1989; 22(10):1271-3.
21 Norman GR, Streiner DL. Biostatistics - The Bare Essentials. Hamilton. Canadian: B.C. Decker Inc; 1998. 260 p.
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Published
2008-06-30
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Venturini J, Violato NM, Arruda MSP de. Influence of testosterone on macrophages activity cocultured with Trichophyton mentagrophytes. Hansen. Int. [Internet]. 2008 Jun. 30 [cited 2024 Jul. 22];33(1):19-24. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35172
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