Keywords
leprosy
tumor necrosis factor aTNF
How to Cite
Abstract
To verify the immunologic alternations related to the polar forms of leprosy the aTNF (tumor necrosis factor), levels was determined in vivo" and in vitro" in 31 individuals: lepromatous leprosy - 1, tuberculoid leprosy - 10 and normal controls - 10. PBMC (peripheral blood mononuclear cells) were cultured during 24 hs/379C/CO2 atmosphere and aTNF levels were easured by ELISA assay, at the cultures supernatants and the serum from the three groups of individuals. The results (pg/ml) showed TNF levels significantly higher in tuberculoids patients when compared with the levels of lepromatous leprosy (LL) or controls, indicating a deficit in development and maintenance of immunecellular response, favouring the infection dissemination in LL
patients. The negative correlation between aTNF levels and baciloscopic index suggest that elevated baciloscopic levels are associated with immunecelular supression.
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