Abstract
The aim of this study was to determine the prevalence of DDS resistance in lepromatous leprosy patients in Baum, São Paulo. In a population of 349 of such patients (205 with more than 5 years of treatment and thus in a high risk of developing resistance) 30 (14.63%) showed clinical signs of possible resistance (Bl of 3+ or higher). 10 patients presented bacilli resistant to DDS 2,86%). For this reason , authors conclude that nationwide implementation of MDT is of utmost importance.
References
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de Leprol. 2(2): 47, 1953.
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patients in Costa Rica: their metabolic disposition of DDS. Int. J. Leprosy 44:143-51,1976.
27. PETTIT, J.H.S. & REES, R.J.W. Sulfone resistance in leprosy. An experimental and clinical study. LANCET 2. 673, 1964.
28. QUAGLIATO, R. O problema das reativações nos dispensários de lepra. Rev. bras. Leprol. 23(1): 83-113, 1955.
29. RABELLO, F.G. Simpósio sobre experiência brasileira com a sulfonoterapia. Arq. min. Leprol. 12(4):285-426, 1953.30. SHEPARD, C.C. The experimental disease that follows the injection of human leprosy bacilli into foot pads of mice. J. exp. Med. 112:445-54, 1960.
31. SOUZA LIMA, L. & ARANTES, F.R. Resistência do bacilo de Hansen à quimioterapia. in Anais do VIII Congresso Internnacional de Leprologia. Rio de Janeiro, 1963. pgs. 414-437.
32. W ORDL HEALTH ORGANIZATION. Dapsone-resistant leprosy-The THELEP approach. Int. J. Leprosy 49(4):421-25, 1981.
2. BAOHONG, J.; JIAKUN, Z.; YUHONG, H.; GUOXING, N.; & RENBAO, Z. Secondary dapsone resistant leprosy in Shangai municipality. Leprosy Rev. 54:197-202,1983.
3. BAQUILON, G.; FERRACCI, C.; VAN-LOO, G.; PATTYN, S.R. Further results on dapsoneresistant leprosy in Bamako (Mali). Leprosy Rev. 54:19-21, 1983.
4.BECHELLI, L.M. Experiência brasileira com a sulfonoterapia: relatório do Dispensário nº 2 da sede do D.P.L. Arq. min. Leprol.
12(4):286-294, 1953,
5.BOURLAND, J.; VAN-LOO, G.; & PATTYN, S.R. Dapsone resistant leprosy in Burundi. Leprosy Rev. 54:239-42, 1983.
5. CHAUSSINAND, R. Aspect atue) du probleme de la lepra. Mt. J. Leprosy20(2): 229-238, 1952.
7. CONGRESSO INTERNACIONAL DE LEPROLOGIA, 6º, MADRID, 1953, Memórias, Madrid, 1953.
7. CONGRESSO INTERNACIONAL DE LEPROLOGIA, 7º , TOKIO, 1958, Memórias. Toldo, 1958.
9. COSTA, H.C.; SOUZA, L.C.D.; SAVRON, V.B.; PRADO, D.A.C. & LOSNAK, L.M. Procedimentos utilizados para a manutenção de linhagem isogênica decamundongos Mus musculus, estirpe BALB/c, para o uso no estudo da resistência do Mycobacterium leprae à
Diamino difenil sulfona (DDS) Salusvita 8(1):69-71, 1989.
10. COSTA, H.C.; LOSNAK, L.M.; MADEIRA, S.; COELHO, A.A.M.; WINCE, P.S.; SAVRON, V.B. Curva de crescimento padrão do
Mycobacterium leprae em coxim plantar de camundongos Mus musculus, estirpe BALB/c, isogênicos, do biotério do Instituto
Lauro de Souza Lima, Bauru, Estado de São Paulo. Salusvita 9(1):01-07, 1990.
11. DAVEY, T.F. Progress with new anti-leprosy drugs. In: International Leprosy Congress, 7°, Tokio, 1958, Transactions, Tokio, 1959.
p. 252-259.
12. DAVIDSON, J.A. Isoniazid alone and combined with triosemicarbazone. Leprosy Rev. 24:104-106, 1955.
13. FLOCH, H. La sulfone resistance de bacile de Hansen. Arch. Inst. Pasteur Guyane French.429: 1947.
14. GARROD, J.M.B. Colonial Medical Research Committe, 15th Annual Report, 1959, 1960. nº 2 da sede do D.P.L. Arq. min. Leprol.
12(4):286,1953.
15. GUINTO,R.S.; CELLONA, R.V.; FAJARDO, T.T. & CRUZ, E.C. dela. Primary dapsone resistant leprosy in Cebu, Philipines. Int. J. Leprosy 49(4): 427-430, 1981.
16. JOPLING, R. The treatment of leprosy. Pos graduated Medical Journal 136: 634, 1960.
17. LEVY, L.; RUBIN, G.S. & SHESKIN, J. The prevalence of dapsone resistant leprosy in Israel. Leprosy Rev, 4&107-12, 1977.
18. LOWE, J. The treatment of leprosy with TBI/698: A report based on 38 months experience. Leprosy Rev. 24:186-199, 1954.
19. MARIANO, J. Dez anos de experiência com a sulfonoterapia. Arq. min. Leprol. 16(2):93-107, 1956.
20. MEADE, T.W.; PEARSON, J.M.H.; REES, R.J.W. & NORTH, W.R.S. The epidemiology of sulphone resistant leprosy. Int. J. Leprosy 41(4):684, 1973.
21. MIRANDA, R.N. Recaída de caso de lepra lepromatosa. Arq. Paranaense de Leprol, 2(2):51, 1953.
22. MOURA, A.M. & ROCHINE, S. Vinte casos de recaída entre doentes transferidos para tratamento ambulatorial. Arq. Paranaense
de Leprol. 2(2): 47, 1953.
23. OPROMOLLA, D.V.A. Terapêutica multidroga. An. bras. Dermatol 65(1):37-40, 1990.
24. PEARSON, J.M.H.; HAILE, G.S.; BARNETSON, R.St.C. & REES, R.J.W. Dapsone-resistant leprosy in Ethiopia. Leprosy Rev. 50:183-99, 1979.
25. PEARSON, J.M.H.; REES, R.J.W.; WATERS, M.F.R. Sulphone resistance in leprosy. A review of one hundred proven clinical cases.
Lancet 2.69-72, 1975.
26. PETERS, J.H.; SHEPARD, C.C.; GORDON, G.R.; ROJAS, A.V. & ELIZONDO,D.S. The incidence of DDS resistance In lepromatous
patients in Costa Rica: their metabolic disposition of DDS. Int. J. Leprosy 44:143-51,1976.
27. PETTIT, J.H.S. & REES, R.J.W. Sulfone resistance in leprosy. An experimental and clinical study. LANCET 2. 673, 1964.
28. QUAGLIATO, R. O problema das reativações nos dispensários de lepra. Rev. bras. Leprol. 23(1): 83-113, 1955.
29. RABELLO, F.G. Simpósio sobre experiência brasileira com a sulfonoterapia. Arq. min. Leprol. 12(4):285-426, 1953.30. SHEPARD, C.C. The experimental disease that follows the injection of human leprosy bacilli into foot pads of mice. J. exp. Med. 112:445-54, 1960.
31. SOUZA LIMA, L. & ARANTES, F.R. Resistência do bacilo de Hansen à quimioterapia. in Anais do VIII Congresso Internnacional de Leprologia. Rio de Janeiro, 1963. pgs. 414-437.
32. W ORDL HEALTH ORGANIZATION. Dapsone-resistant leprosy-The THELEP approach. Int. J. Leprosy 49(4):421-25, 1981.
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