Keywords
Liver
Herbs
How to Cite
Abstract
The present study incorporates a study of 42 cases of lepromatous leprosy for hepatic involvement and role of indigenous herbal preparation in protecting the liver in leprosy. Liver was enlarged in 32 cases which was tender in 8 patients. Alteration in liver function irrespective of extent and duration of the illness (3 months to 10 years with mean duration of illness = 2 years 5 months) was mainly seen as uniform elevation of serum proteins (6.2-9.2 gms%, mean = 7.5 gms%) with hypoalbuminaemia (2.0-4.4 gms%, mean = 2.9 gms%). Highest level of serum bilirubin of 1.6 mg% was detected in 6 cases, emphasising the presence of leprous hepatitis. Raised level of serum transaminases (SGOT = 65.2 IU, SGPT = 78.7 IU) were proportionate to the liver and muscle involvement. Presence of characteristic granulomata in the liver around the central vein, periportal area and even distribution at various locations in the liver lobules were the most significant changes in 12 out of 15 liver tissues. Acid fast M. leprae were demonstrated in 12 patients. The present work emphasises the detection of hepatic involvement in the early stage of the disease and hepato-protective role of indigenous drug Liv-52 in lepromatous leprosy which usually lead to dreaded mutilated complications in the body.
References
2 BASU, B.D. & KIRTIKAR, K R Indian medicinal plants. 2.ed. New Delhi, C.S.I.R., 1975.
3 DAVE, D.S.; RAJPUT, V.J.; GUPTA, M.R. Clinico-biochemical study of infective hepatitis with special reference to Liv-52. Probe, 11:244, 1972.
4 DESIKAN, K.V. & JOB, C.K. A review of postmortem findings in 37 cases of leprosy. Int. J. Lepr., 86(1) :32-44, 1968.
5 DHARMENDRA & CHATTERJEE, S.N. Diagnosis. In : DHARMENDRA. Leprosy. Bombay, Kothari Medical Publishing House, 1978. v.1, sect.3, p.245-282.
6 DHARMENDRA & RAMANUJAM, K. The lepromatous type. DHARMENDRA. Leprosy. Bombay, Kothari Medical Publishing House, 1978. v.1, cap.5, p.62-75.
7 DHOPLE, A.M. & BALAKRISHNAN, S. Liver function tests in leprosy. Ind. J. Med. Res., 56:1552-1558, 1968.
8 GHARPURAY, S.M.; GHARPURAY, M.B.; KELKAR, S.S. Liver function in leprosy. Lepr. India, 49 (2) : 216-220, 1977.
9 GUPTA, M.C.; KUMAR, S.; TYAGI, S.P. Reappraisal of functional and structural changes in the liver in leprosy. J. Ass. Phys. India, 22: 13-18, 1974.
10 LODHA, S.C.; BOMB, B.S.; SINGH, S.V.; SHARMA, N.L. A comparative study of liver function tests in various types of leprosy. J. Ass.
Phys. India, 22:653-657, 1974.
11 MOHANTY, H.C. & MURTI, R.S. Serum transaminase in leprosy. Lepr. India, 45(3):163-166, 1973.
12 NIGAM, P.; DAYAL, S.G.; GOYAL, B.M.; NIMKHEDAKAR, K.V.; JOSHI, L.D.; SAMUEL, K.C. Leprous hepatitis: clinico-pathological study
and therapeutic efficacy of Liv-52. Lepr. India, 50(2) :185-195, 1978.
13 NIGAM, P.; MUKHIJA, R.D.; GOYAL, B.M. Study of histo-functional complex of liver in leprosy. Ind. J.Dermatol. Venereol. Leprol.,
42(5) : 217-222, 1976.
14 POWELL, C.S. & SWAN, L.L. Leprosy--pathological changes observed in 50 consecutive cases. Am. J. Pathol., 31:1131-1141, 1955.
15 PRASAD, G.C. Effect of Liv-52 on the liver in vitro. J. Res. Ind. Med., 4:15-23, 1975.
16 SALASKAR, V.H. Diagnostic evaluation of the hepatic function tests. Probe, 17:97-109, 1978.
17. SAMUEL, K.C. & CHATTERJEE, S.N. Modification of Fite Faraeo staining for acid fast bacilli. Ind. J. Path. Bact., 14 (2) :107-109, 1971.
18 SIMONS, R.D.G. Leprology to-day. Excerpta Med. Dermatol. Venereol., 10:349-354, 1956.
19 SINHA, P.K.; KUMAR, A.; PATNEY, N.L. A study of therapeutic action of Liv-52. Probe, 18:157-166, 1979.
20 SULE, E.A. Liver in leprosy. J. Ind. Med. Prof., 12:6391, 1968.
21 TILDEN, I.L. Lepromatous leprosy: a reticuloendothelial disease; histopathological aspects. Am. J. Clin. Path., 15:165-177, 1945.
22 WILLIAMS JR., R.C.; CATHART,.E.S.; CALKINS, E.; FITE, G.L.; RUBIO, J.R.; CHOEN, A.S. Secondary amyloidosis in lepromatous leprosy.
Ann. Int. Med., 62:1000-1008, 1965.
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