Estudios inmunolágicos en pacientes de lepra indeterminada
DOI:
https://doi.org/10.47878/hi.1978.v3.35640Keywords:
Indetermined hanseniasis, Mitsuda reaction, T lymphocytes, Rosette testsAbstract
A longitudinal study was made in a group of indeterminate hanseniasis patients; immunological tests (Mitsuda's reaction and E rosettes formation) and clinical observations were performed in 1973 and in 10977 respectively. A significative difference was observed in the E rosettes formation between "lepromin" positive and "lepromin" negative patients (p < 0,001) in 1973; this difference increased (p < 0,01) in 1977. The immune response was related with the evolution to the polar types of the disease, depending or not on specific treatment. Patients presenting normal values of E rosettes in 1973 showed reversal of the Mitsuda reaction suggesting that this test could be used for prognosis.
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References
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2. BALIÑA, P. L. & BASOMBRIO, G. Classification des formes cliniques de lépre.Rev. Bras. Leprol., 6(3):225-228, 1938.
3. BARBA RUBIO, J.; SOUZA LIMA, M.; SOUZA LIMA, L.; SOUZA, P. R. Bases patogenéticas de la classificacion sudamericana de la lepra. Temas Leprol., 21(6):3-9,1974.
4. BIANCO, C.; PATRICK, R.; NUSSENZWEIG, V. A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Exp. Med., 132(4):702-720, 1970.
5 CAROSELLA, E. D.; MOCHANKO, K.; BRAUN, M. Rosette-forming T cells in human peripheral blood at different ages.Cell. Immunol., 12(2):323-325, 1974.
6. DWYER, J. M.; BULLOCK, W. E.; FIELDS, J. P. Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy: clinical and immunologic correlactions. N. Eng. J. Med.. 288(20):1036-1039, 1973.
7. FLIESS, E. L. Inmunologia de la lepra.Temas Leprol., 20(59):3-32, 1976.
8. FLIESS, E. L. & BACHMANN, A. E. Alteración de la inmunidad mediada por células en enfermos de lepra.Rev. Asoc. Argent. Microbial., 9(1):28-36, 1977.
9. FLIESS, E. L.; BACH_MANN, A. E.; SABIAIN, M. C.; RUIBAL, A. B. Exploración inmunologica en pacientes con lepra indeterminada.Rev. Asoc. Argent. Microbial., 7(3):8I 1975.
10. FLIESS, E. L. & CAROSELLA, E. D. Linfocitos T formadores de Rosetas (LFR) en pacientes de lepra incaracteristica.Rev. Leprol. Fontilles, /0(1):21-25, 1975.
11. FLIESS, E. L. & PACIN, A. M. La respuesta inmunológica a través del espectro clinico de la lepra. In: REUNION LEPROLOGICA DEL CONO SUD, 2.a, Buenos Aires, 1977 apud Soc. Argent. Leprol., /(3):3, 1977.
12. GAJL-PECZALSKA, K. J.; LIM, S. D.; JACOBSON, R. R.; GOOD, R. A. B lymphocytes in lepromatous leprosy. N. Eng. J. Med., 288(20): 1033-1035, 1973.
13. GODAL, T.; MYRVANG, G.; STANFORD, J. L.; SAMUEL, D. R. Recent advances in the immunology of leprosy with special reference to new approaches in immunoprophylaxis. Bull Inst. Pasteur, 72:273-310, 1974.
14. HANKS, J. H. Cultivation of M. leprae by Soule. Correspondence. Int. J. Lepr., 33 (1):104-105, 1965.
15. INFORME de la comision de clasificacion. In: CONFERENCIA PANAMERICANA DE LA LEPRA, 2.a, Rio de Janeiro, 1946 apud Temas Leprol., 6(19):1-11, 1947.
16. JOPLING, W. H. A classification of leprosy. Leprologia, 19(2):127-132, 1974.
17. NATH, I.; CURTIS, J.; BHUTANI, L. K.; TALWAR, G. P. Reduction of a subpopulation of T lymphocytes in lepromatous leprosy.OM. Exp. Immunol., 18(1):81-87, 1974.
18. REPORT on the Madrid Congress. Editorial. In: INTERNATIONAL CONGRESS OF LEPRO- LOGY, 6th, Madrid, 1953 apud Int. J. Lepr., 21(4):477-483, 1953.
19. RIDLEY, D. . & JOPLING, W. H. A classification of leprosy for research purposes. Lepr. Rev., 33(2):119-128, 1962.
20. RIDLEY, D. S. & JOPLING, W. H. Classification of leprosy according to immunity: a fivegroup system. Int. J. Lepr., 34(3):255-273, 1966.
21. RODRIGUEZ, J. N. Observations on the classification of leprosy. Int. J. Lepr., 15(3):274-302, 1947.
22. SERIAL, A. Lepra indeterminada fisiopatologica y evolucion histopatologica. Leprologia, 19(2): 144, 146, 1974.
23. SKINSNES, O. K.; GODAL, T.; ABE, M.; JOB, C. K.; PEARSON, J. M. H.; RIDLEY, D. S.; ULRICH, M.; WEISER, R. S. Advances in immunopathology. In: INTERNATIONAL LEPROSY CONGRESS, 20th, Bergen, 1973 apud Int. J. Lepr., 41(4):456-461, 1973.
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Published
1978-06-30
How to Cite
1.
FLIESS EL, HERRERA MD, CAROSELLA ED, BALIA LM, CARDAMA JE, GATTI JC. Estudios inmunolágicos en pacientes de lepra indeterminada. Hansen. Int. [Internet]. 1978 Jun. 30 [cited 2024 May 19];3(1):42-7. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35640
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