II. Quantitation of the serum immunoglobulins. Tentative association to rubino's reaction
DOI:
https://doi.org/10.47878/hi.1976.v1.35674Keywords:
Hanseniasis, Rubino's reaction, Electrophoresis, Immunoelectrophoresis, Radial immunodiffusionAbstract
Sera from 60 virchowian patients of hanseniasis (30 Rubino positive and 30 Rubino-negative) and 16 tuberculoid patients (Rubino-negative) were analysed through the guantitation of immunoglobulins by single radial immunodif fusion. There was an increase of the IgG and IgA levels in the two virchowian groups. The levels of IgM were augmented only in Rubino-positive virch,owians. The IgD levels were normal in the three groups. In the tuberculoid patients only in the IgG class was observed increase. It seems that the Rubino-positive group is probably more responsive or more stimulated by antigenic action than Rubino-negative group.
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References
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2. BULLOCK JR., W. E.; HO, M. F.; CHEN, M. J. Studies of immune mechanisms in leprosy. II. Quantitative relationship of IgG, IgA and IgM immunoglobulins. J. Lab. Clin. Med., 73(5) :863-870, 1970.
3. CLAMAN, H. N. & MERRILL, D. Hypergammaglobulinemia; the role of the immunoglobulins (gamma G, gamma A, gamma M). J. Allergy, 36:463- 471, 1965.
4. DAMMACCO, F.; GIUSTINO, V.; BONOMO, L. The occurrence of serum 75 IgM in diseases associated with immunoglobulin abnormalities. hat. Arch. Allergy, 38:618-626, 1970.
5. JHA, P.; BALAKRISHNAN, K.; TALWAR, G. P.; BHUTANI, L. K. Status of humoral immune responses in leprosy. Int. J. Leprosy, 33(1) :14-19, 1971.
6. LIM, S. D. & FUSARO, R. M. Leprosy. IV. The quantitation of immune globulins (IgG, IgA and IgM) in leprosy sera. Int. J. Leprosy, 36(2): 144-153, 1968.
7. MCKELVEY, E. M. & FAHEY, J. L. Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gamma G), IgA (gamma A), and IgM (gamma M), and of light polypeptide chains, type K (I) and type L (II). J. Clin. Invest., .44:1778-1787, 1965.
8. MANCINI, G.; CARBONARA, A. O.; HEREMANS, J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry, 3:235-254, 1965.
9. PEREIRA, J. M. CALLADO, A. N. A.; CONSTÂNCIO, W. F.; LAJCHTER, D.; VIEIRA, A. A. Determinação quantitativa de imunoglobulinas (imunodifusão radial). R. MM. Est. Guanab., 38(2) :153-161, 1971.
10. ROWE, D. S.; CRABBÉ, P. A.; TURNER, M. W. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin. Exp. Immunol., 3:477-490, 1968.
11. RUBINO, M. C. Séro-diagnostic de la 1èpre par l'agglutino-sedimentation desglobules de mouton formoles. Ann. Inst. Pasteur, 47:147-172, 1931.
12. SAGHER, F.; SHESKIN, J.; ZLOTNICK, A.; TURK, J. L. Complement and immunoglobulin determinations in leprosy and lepra reaction. ./nt. J. Leprosy, 39(2) :541-553, 1971.
13. SHEAGREN, J. N.; BLOCK, J. B.; TRAUTMAN, J. R.; WOLFF, S. M. Immunologic reactivity in patients with leprosy. Ann. Intern. Med., 70: 295-302, 1969.
14. SIEGEL, S. Nonparametric statistics for the behavioral sciences. New York, McGrawHill, 1956. p.116, 184, 202.
15. SILVA, O. P.; FERRI, R. G.; MORAES, N.; MARQUES, A. L. V. Estudos imunoquimicos na hanseníase. I. Eletro e imunoeletroforese das proteínas séricas. Tentativa de associação com a reação de Rubino. (No prelo)
16. TAMBLYN, E. & HOKAMA, Y. C-reactive protein, immunoglobulin and serum protein analyses of sera from cases of lepromatous leprosy and tuberculosis. Int. J. Leprosy, 37(1) :68-73, 1969.
17. WEMAMBU, S. N. C.; TURK, J. L.; WATERS, M. F. R.; REES, R. J. W. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933-935, 1969.
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Published
1976-06-30
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SILVA OP, FERRI RG, MORAES N, MARQUES ALV. II. Quantitation of the serum immunoglobulins. Tentative association to rubino’s reaction. Hansen. Int. [Internet]. 1976 Jun. 30 [cited 2024 May 20];1(1):43-52. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35674
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