Genética na Hanseníase

Abstract

The research lines which have been explored to evaluate the importance of human genetic constitution on the determination of resistance and susceptibility to Mycobacterium leprae were reviewed. A critical analysis of the investigations on the familial recurrence of hanseniasis, familial association of the polar types of hanseniasis, íntrafamilial contagion risks, population distribution of hanseniasis, concordance of hanseniasis manifestations in twin pairs, Mitsuda reaction in faminrya and in twin pairs, in vitro reaction of blood macrophages to killed M. leprae, selected pedigrees, dermatoglyphics, associations of genetic polymorphisms to hanseniasis, and chromosomal aberrations was presented.