Keywords
Leprosy
Dapsone
Drug Hypersensitivity
Dapsone
Drug Hypersensitivity
How to Cite
1.
Marques GF, Barreto JA, Sousa JMP, Brandão LSG, Nigro MHMF. Sulfone syndrome: A severe hypersensitivity reaction. Hansen. Int. [Internet]. 2012 Nov. 30 [cited 2026 Jun. 17];37(2):86-90. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36203
Abstract
Dapsone is a drug used to treat leprosy and other skin diseases. Even in normal doses can cause a condition called sulfona syndrome, characterized by fever, hepatitis exfoliative dermatitis, generalised lymphadenopathy, hemolytic anemia and atypical lymphocytes in peripheral blood. It’s a rare and severe hypersensitivity reaction to sulfone with an unpredictable clinical course. The authors report a case of sulfone syndrome, emphasizing its main clinical, laboratory and histopathological findings.
References
1 Pfeiffer C, Wozel G. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol. 2003;48(2):308-9.
2 Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G. The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominenthepatopulmonary manifestations. J Occup Med Toxicol. 2006;1(9).
3 Derungs A, Rätz Bravo AE, Kummer O. Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms). Praxis. 2010;99(13):767-77.
4 Grace M. An unusual case of dapsone syndrome. Indian Dermatol Online J. 2011;2(2):88-90.
5 Barbosa AM, Martins Junior E, Fleury RN, Opromolla, DVA. Mais um caso da síndrome da sulfona. Hansenol Int. 2000;25(2):159-62.
2 Kosseifi SG, Guha B, Nassour DN, Chi DS, Krishnaswamy G. The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominenthepatopulmonary manifestations. J Occup Med Toxicol. 2006;1(9).
3 Derungs A, Rätz Bravo AE, Kummer O. Rash, fever, eosinophilia and elevated liver enzymes. DRESS syndrome (drug reaction or rash with eosinophilia and systemic symptoms). Praxis. 2010;99(13):767-77.
4 Grace M. An unusual case of dapsone syndrome. Indian Dermatol Online J. 2011;2(2):88-90.
5 Barbosa AM, Martins Junior E, Fleury RN, Opromolla, DVA. Mais um caso da síndrome da sulfona. Hansenol Int. 2000;25(2):159-62.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Downloads
Download data is not yet available.
