Quantificação do estresse oxidativo no sangue de hansenianos sob efeito ou não de tratamento especifico

Luiz Fernando Rimolil; Moacir Fernandes de Godoy

doi:10.47878/hi.2001.v26.36402

Authors

Luiz Fernando Rimolil Mestre em Ciências da Saúde - Faculdade de Medicina de São Jose do Rio Preto - FAMERP
Moacir Fernandes de Godoy Chefe do Departamento de Cardiologia e Cirurgia Cardiovascular da Faculdade de Medicina de São José do Rio Preto - FAMERP

DOI:

https://doi.org/10.47878/hi.2001.v26.36402

Keywords:

Leprosy, oxidative stress, methemoglobin, Heinz's bodies

Abstract

In this study we evaluated the quantification of the oxidative stress in the blood of people with Hansen's disease undertaking or not a specific treatment. It was colleted blood samples of 62 people carriers of Hansen and 13 healthy people. From these 62 patients, 35 were of multibacilar form and were being treated with clofazimine, dapsone and rifampicine; 16 of the paucibacilar form treated with dapsone and rifampicine; 11 of the patients were taking no treatment, being 5 of the multibacilar form and 6 of the paucibacilar form. The blood samples colleted were taken for laboratory analyses where were made the dosage of methemoglobin and count of Heinz's bodies. The obtained results were submitted statistical analyses according to the Odds Ratio and Confidence Interval 95%. We concluded that the oxidative stress was caused by the therapy administered, not by the Hansen's disease itself, and the group that was taking clofazimine showed worse results, that is, higher oxidative stress.

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References

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