Abstract
An 86 years old male was referred to the "Instituto Lauro de Souza Lima" 20 years ago with subpolar lepromatous leprosy, saddle nose and subtotal madarosis. Two months after the beginning of the treatment for Hansen's disease, the patient presented a type I reaction with neuritis. A biopsy showed a tuberculoid granulomatous reaction in the skin and nerves. During a second episode of a type I reaction he developed a severe laryngitis with upper respiratory obstruction and was submitted to a tracheostomy Several other episodes of type I reaction appeared until the patient became cured, seven years ago, after he had been under several therapeutic regimens. Short after he had been released from treatment, new skin lesions developed as several esquamous macules with well-limited edges. In 1997 some biopsies confirmed the diagnosis of mycosis fungoides. The authors discuss: a) the pathogenesis of the several episodes of a type I reaction and laryngeal involvement. b) possible relationship between multibacillary leprosy and mycosis fungoides. c) difficulties found on diagnosis of mycosis fungoides in this case.
References
2. CONVIT, J., PINARD, M.E., ARIAS ROJAS, F. Some considerations regarding the immunology of leprosy. Int. J. Leprosy, v.39, p.556-564, 1971.
3. FLEURY, R. N. Manifestações sistêmicas. In: TALHARI, S., NEVES, R.G. Hansenfase. 2 ed. Manaus:ESEA, 1989. p.73-77.
4. FLEURY, RN, BASTAZINI, I. Reação hansênica com lesões viscerais. Hansen Int., v.3, p.87-93, 1978.
5. FLEURY, R. N., TONELLO, C., URA, S, ZORZETO, V. Hanseníase dimorfa com surtos de reação hansênica e lesões viscerais. Hansen. Int., v.4, p.116-25, 1979.
6. FLEURY, R.N. ZORZETO, V. TONELLO, C.S., PERNAMBUCO, J.C.A. Surto de pseudo-exacerbação em paciente dimorfo com vasculites granulomatosas especificas disseminadas. Hansen. Int.. v.5, p.44-52, 1980.
7. FLEURY, R.N., OPROMOLLA, D.V.A., TONELLO, C.J.S. Meningoencefalite por Criptococcus Neoformans como complicação de Insuficiência vascular arteriosclerótica em hanseníase virchoviana. Hansen Int., v.6, p.146-153, 1981.
8. FLEURY, RN., OPROMOLLA, D.V.A. Hanseníase virchoviana, Fenômeno de Lúcio, Criptococose.. Hansen Int., v.13, p.47-55, 1988.
9. FLEURY, R.N., OPROMOLLA, D.V.A. Septicemia com múltiplas lesões ósseas supurativas como complicação do eritema nodoso hansênico. Hansen. Int., v.15, p.76-86, 1990.
10. FLEURY, RN., OPROMOLLA D.V.A. Hansenfase dimorfa com padrões diversos de reação granulomatosa em pele e vísceras. Hansen. Int., v.20, p.49-54. 1995.
11. FLEURY, R.N., URA, S., OPROMOLLA, D.V.A. Fenômeno de Lúcio (Eritema necrosante) Hansen. Int., v.20, p.60-65, 1995.
12. GROSSMAN, D., RAPINI, RONALD P., OSBORNE, B., DUVIC, M. Emergence of leprosy in a patient with mycosis fungoides. J. Amer. Acad. Derm., v.30, n.2, pt.2, p.313-315, February, 1994.
13. HARBOE, M. Overview of host-parasite relations. In: HASTINGS, R.C. Leprosy. 2 ed. New York: Churchill Livingstone, 1993. p.87-111.
14. JOPLING, W.H. Leprosy reactions (reational states). In: _______ . Handbook of leprosy. 2 ed. London: William Heinemann Medical Books, 1978. p.66-74.
15. KAUR GILL, H., GODAL, T. Deficiency of cell immunity in leprosy. Prog. Allergy, v.37, p.377-390, 1986.
16. MOHAMED, K. N. Dermatological disoreders resembling leprosy. Singapore Med. J. v. 30, p. 265-269, 1989.
17. OPROMOLLA, D.V.A., FLEURY, R.N. Síndrome da Sulfona e reação reversa. Hansen Int., v.19, n.2, p.70-76, 1994.
18. RIDLEY, D.S. Classificacion y espectro. In: - la biopsia de piel em la lepra. 2 ed. Basilea:Ciba-Geisy, 1987. p.41-51.
19. SOUZA LIMA, L. The "Pseudoexacerbation" reactional state of leprosy. Int. J. Leprosy, v.23: 425-434, 1955.
20. TRIFILIO, M.O., BELONE, A.F.F., FLEURY, R.N. Avaliação baciloscópica na hanseníase virchoviana. ( Estudo de 60 necrópsias ) Hansen. Int., v.22, n.2, p.10-19, 1997.
21. TUYP, E., BURGONE, A., AITICHISON, T, MAC KEE, R A case control study of possible causative factors in Mycosis fungoids. Arch. Derm., v.123: 196-200, 1987.
This work is licensed under a Creative Commons Attribution 4.0 International License.