Keywords
Lewis phenotype
Secretor phenotype
Blood group
Leprosy
How to Cite
Abstract
The distribution of Lewis blood group phenotypes in the saliva and on the erythrocytes of leprosy patients were evaluated, Forty seven patients and forty controls were analyzed by means of an agglutination and agglutination inhibition test for the presence of ABH and Lewis antigens on erythrocytes and in the saliva, The frequency of the Lewis phenotypes and secretor and non-secretor phenotypes were determined among the patients and in the control group. The results were: Le(a- b+) =29,8% (62,5%); Le(a+ b-) = 25,5% (7,5%); Le(a- b-) = 44,7% (30,0%); secretor = 59,5% (85%) and non secretor = 40,5% (15%) respectively. Statistical analysis using the X2 test showed significant difference between patients and controls concerning the Lewis phenotype (x2 = 10,46; D,F. = 2; p= 0,005) and secretor phenotype (x2 = 5,64; D.F. = 1; p = 0,018), Using the Z test
significant differences were found concerning the phenotypes Le (a+ b-) and Le (a- b+) (Z = 2,219; p = 0,027 and Z = 3,058; p = 0,002). The results
indicate that phenotype Le (a+ b-) is associated with susceptibility to leprosy and secretor phenotype with protection. It is speculated that the presence of Leb' in the saliva inhibits the adherence of M, leprae to the mucosa cells thus protecting against infection.
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