Aplicação do teste Elisa anti-PGL-1 em localidade com alta endemicidade de hanseníase na região norte do estado de São Paulo

Mitie Tada L.R.F. Brasil; Luiz Roberto de Oliveira; Carmen Silvia de Melo; Paulo Mutuko Nakamura; Nelly S. Rimoli; Sérgio Cavalari Filho; Márcia B. Oliveira; Vera L. Gattás; Otília S. J. Gonçalves; Osmar Rotta

doi:10.47878/hi.1998.v23.36463

Authors

Mitie Tada L.R.F. Brasil Centro de vigilância Epidemiológica Prof. A. Vranjac - SES - SP
Luiz Roberto de Oliveira
Carmen Silvia de Melo
Paulo Mutuko Nakamura
Nelly S. Rimoli
Sérgio Cavalari Filho
Márcia B. Oliveira
Vera L. Gattás
Otília S. J. Gonçalves
Osmar Rotta

DOI:

https://doi.org/10.47878/hi.1998.v23.36463

Keywords:

Leprosy, Endemy, Epidemiology, Phenolic-glyco lipid ( PGL-l), Elisa

Abstract

Serum tests for the diagnosis of leprosy using the phenol-glycolipid-1 antigen (PGL-l) had opened several possibilities to the study of the epidemiological behavior of this disease. This research aimed on the evaluation of the results of using ELISA anti PGL-1 on an urban community with high leprosy endemicity in the State of São Paulo, Brazil. It presented, at the research time, detection and prevalence rates (27.1 and 167.2 cases per 10,000 inhabitants, respectively). A census reveled 8,491 persons living in the urban area and 6,666 of them were tested with the ELISA anti PGL-1. The serology was positive in 9.0% of the general population, 10.1% for the female population and 7.6% for the male population. Positive serology observed among women was higher in almost all age levels, except for those 50 years old or more. Among the registered patients the serum positive rate reached 22.6%. The high rate of clinically normal persons testing positive may be indicative of sub-clinical infection. Some unsolved questions remain, such as: which of these persons will present the disease and when. It also remains to be evaluated how this serology will perform in communities in medium to low endemic areas. Low sensibility of the test does not commend its general adoption as a diagnosis method in routine control programs activities. Nevertheless, it is considered important not to discard it as a research object to improve its sensibility, specificity and lower its cost. Thus, another instrument for the control and elimination of leprosy could be established.

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