Keywords
Histogenetic di fferent iation
Polar tuberculoid granuloma
Granulomatous inflammation
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Abstract
B a s e d o n a n ew mo r p h o l o g i c a l c o n c e p t a n d c l a s s i f i c a t i o n o f
granulomatous inflammation: the polar granulomas, on the histogenesis of the tuberculoid
granuloma of the posi t ive Mi tsuda test and on the relat ionship between the degree of
histogenetic differentiation and behaviour of tumors, the Authors concluded that the "benign" or
"malignant" behaviour of hanseniasis depends on the degree of tuberculoid differentiation of the
lesions. If the lesion is histologically well differentiated toward a polar tuberculoid granuloma
(tuberculoid hanseniasis) it will have a "benign" behaviour. On the contrary, if this
differentiation is absent (virchowlan hanseniasis) or poor (interpolar bordeline hanseniasis)
the behaviour of the lesion will be "malignant".
References
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3 - MICHAL ANY, J. & MICHA L ANY , N.S. Patologia da hanseníase. Com especial referência à contribuição dos pioneiros hansenologistas de São Paulo. São Paulo, Platina, 1988. 37p.
4 - M I C H A L A N Y , N.S. & MICHA L ANY , J . Hi s t o p a t o l o g i a d a r e a ç ã o d e Mi t s u d a em adul tos sadios não comunic antes de hansenianos. Hansen. Int., 8:105-123, 1983.
5- ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease; based on 1.529 lepromin tested cases. Rev. Bras. Leprol., 5:45-97, 1937.
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