Conversion of the C3 component of complement in sera of hanseniasis patients
DOI:
https://doi.org/10.47878/hi.1983.v8.35578Palabras clave:
Hanseniasi, Complement 3Resumen
The levels of total C3 (native C3 plus its degradation products) and the degree of conversion of native C3 into its breakdown products were studied in sera of Virchowian (V), tuberculoid (T), indeterminate (I), and Virchowian with erythema nodosum Hansenicum (ENH) patients. Sera from normal individuals (N) were also analysed. While the levels of total C3 were not significantly different among the groups, the percentage of conversion of C3 into its degradation products was significantly higher in V and ENH sera. The activation of the complement system and the involvement of immune complexes (IC) are discussed.
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2 BJOVARTN, B.; BARNETSON, R.S.; KRONVALL, G.; ZUBLER, R.G.; LAMBERT, P.H. Immune complexes and hypercatabolism in patients with leprosy. Clin. Exp. Immunol., 26(3): 388-396, 1976.
3 CONOVER, W.J. Several independent samples. In: Practical nonparametric statistics. New York, Wiley & Sons, 1971. p. 256-263.
4 GELBER, R.H.; EPSTEIN, W.V.; FA- SAL, P.; DRUTZ, D.J. Detection of circulating immune complex-like activity in the sera of patients with erythema nodosum leprosum. In: LEPROSY RESEARCH CONFERENCE, 7., Menlo Park Ca., 1972. Program apud Int. J. Lepr., 40(2): 218-219, 1972.
5 KLIEMANN, T.A.E. Estudo do complemento sérico e da IgA salivar em hansenianos. São Paulo, 1975, 139p. [Tese — Instituto de Biociências da Universidade de São Paulo]
6 KLIEMANN, T.A.E.; FERRI, R.G.; CHAVES, J.; IRULEGUI, I.; VAZ, C.A.C. Detecção de complexos imunes na hanseníase utilizando Clq humano e eqüino. Hansen. Int., 3 (2) :135-140, 1978.
7 MANCINI, G.; CARBONARA, A.O.; HEREMANS, J.F. Immunoehemical quantification of antigens by single radial immunodiffusion. Immunochemistry, 2:235-254, 1965.
8 MARDINEY, M.R. & M$LLER-EBERHARD, H.J. Mouse 131C-globulin: production of antiserum and characterization in the complement reaction. J. Immunol., 94:877-882, 1965.
9 MORAN, C.J.; RYDER, G.; TURK, J.L.; WATERS, M.F.R. Evidence for circulating immune complexes in lepromatous leprosy. Lancet, 2 (7777) : 572-573, 1973.
10 ROJAS-ESPINOSA, O.; MENDEZ-NAVARRETE, I.; ESTRADA-PARRA, S. Presence of Clq-reactive immune complexes in patients with leprosy. Clin. Exp. Immunol., 12:215-223, 1972.
11 SHEAGREN, J.N.; BLOCK, J.B.; TRAUTMAN, J.R.; WOLFF, S.M. Immunologic reactivity in patients with leprosy. Ann. Intern. Med., 70: 295-302, 1969.
12 WEEKE, B. Crossed immunoeleetrophoresin. Scand. J. Immunol., 1 (suppl.) : 47-56, 1973.
13 WEMAMBU, S.N.C.; TURK, J.L.; WATERS, M.F.R.; REES, R.J.W. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933-935, 1969.
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1983-06-30
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Kliemann TAE, Martinez ELW, Irulegu I, Souza ZWT de, Cavalcanti ZM de O. Conversion of the C3 component of complement in sera of hanseniasis patients. Hansen. Int. [Internet]. 30 de junio de 1983 [citado 19 de mayo de 2024];8(1):5-8. Disponible en: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35578
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