Palavras-chave
Talassemia β
Hanseníase
Hemoglobinas anormais
Hanseníase
Hemoglobinas anormais
Como Citar
1.
RAMALHO AS, PINTO JÚNIOR W, MAGNA LA, BEIGUELMAN B. Talassemia e hanseniase. Hansen. Int. [Internet]. 30º de junho de 1983 [citado 23º de novembro de 2024];8(1):61-5. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35590
Resumo
A talassemia β foi investigada em 165 brasileiros descendentes não miscigenados de italianos, 80 dos quais eram doentes de hanseníase, da forma virchowiana, e 85 estudantes universitários (grupo controle). A freqüência da talassemia foi de 6,25% entre os hansenianos e de 5,88% entre os estudantes. Apesar da similaridade da distribuição geográfica tanto da hanseníase quanto do gene da talassemia p em algumas regiões do globo, sobretudo da Ásia, a freqüência de indivíduos com o estigma talassêmico observada nas amostras analisadas não apoia a hipótese de que a hanseníase possa ter contribuído para manter as altas freqüências desse alelo, por intermédio da seleção a favor dos talassêmicos heterozigotos.
Referências
1 ALLISON, A.C. The distribution of the sickle-cell trait in east Africa and elsewhere, and its apparent relationship to the incidence of
subtertian malaria. Trans. Roy. Soc. Trop. Med. Hyg., 48(4):312-318, 1954.
2 ALLISON, A.C. Protection afforded by sickle-cell trait against subtertian malarial infection. Brit. Med. J., 1 (4857) :290-294, 1954.
3 BARNICOT, N.A.; ALLISON, A.C.; BLUMBERG, B.S.; DELIYANNIS, G.; KRIMBAS, C.; BALLAS, A. Haemoglobin types in Greek populations. Ann. Hum. Genet., 26:229-236, 1963.
4 BETKE, K.; MARTI, H.R.; SCHLICHT, I. Estimation of small percentages of foetal haemoglobin. Nature, London, 184(4702):1877-1878, 1959.
5 CROSBY, W.H. & CONRAD, M.E. Iron balance in thalassemia minor. A preliminary report. Ann. N.Y. Acad. Sci., 119:616-623, 1964.
6 DACIE, J.V. & LEWIS, S.M. Hematologia practica. 2. ed. Barcelona, Toray, 1970.
7 HALDANE, J.B.S. Disease and evolution. Ric. Sei., 19:68, 1949.
8 HEINRICH, H.C.; GABBE, E.E.; OPPITZ, K.H. Absorption of inorganic and food iron in children with heterozigous and homozygous
betathalassemia. Z. Kinderheilkd, 115: 1-22, 1973.
9 LAPPÉ, M.; GUSTAFSON, J.M.; ROBLIN, R. Ethical and social issues in screening for genetic disease. New Engl. J. Med., 286(21)1129-1132, 1972.
10 LIE-INJO, L.E.; LOPEZ, C.G.; HART, P.L. Erythrocyte carbonic anhydrase activity in health and disease. Clin. Chim. Acta, 29:541-550, 1970.
11 MALAMOS, B.; FESSAS, P.; STAMATOYANNOPOULOS, G. Types of thalassaemia-trait carriers as revealed by a study of their incidence in Greece. Brit. J. Haemat., 8(1):5-14, 1962.
12 MOTULSKY, A.G. Hereditary red cell traits and malaria. Amer. J. Trop. Med. Hyg., 13(1) 147-158, 1964.
13 MOTULSKY, A.G. Metabolic polymorphisms and the role of infectious diseases in human evolution. Hum. Biol., 32(1):28-62, 1960. 65
14 PEARSON, H.A.; O'BRIEN, R.T.; McINTOSH, S. Screening for thalassemia trait by electronic measurement of mean corpuscular volume. New Engl. J. Med., 288(7):351-353, 1973.
15 SILVESTRONI, E. & BIANCO, I. The distribution of microcythaemias (or thalassemias). In: JON%IS, J.H.P. & DELAFRESNAY, J.F., ed. Abnormal haemoglobin: a symposium. Oxford, Blackwell, 1959.
16 SINGER, K.; AMOZ, M.D.; CHERNOFF, M.D.; SINGER, L.M.S. Studies on abnormal haemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali desnaturation. Blood, 6(5): 413-428, 1951.
17 STEINER, J.; MARTI, H.R.; DEAN, D. Decreased hemoglobin Aa concentration in iron deficiency anemia. Acta Haemat., 45:77-81, 1971.
18 VANDEPITTE, J. & DELAISSE, J. Sicblémie et paludisme. Aperçu du problème et contribution personnelle. Ann. Soc. Beige Méd. Trop., 87(5): 703-735, 1957.
19 WASI, P.; DISTHASONGCHAN, P.; NA-NAKORN, S. The effect of iron deficiency on the levels of hemoglobins A2 and E. J. Lab. Clin. Méd., 71(1):85-91, 1968.
20 WEATHERALL, D.J. Los síndromes talassémicos. Barcelona, Toray, 1967.
21 WEHINGER, H. Untersuchungen über die Erythrociten-Carboanhydrasen bei pathologischen Zustanden in Kindesalten. Z. Kinderheilk, 114:163-174, 1973.
subtertian malaria. Trans. Roy. Soc. Trop. Med. Hyg., 48(4):312-318, 1954.
2 ALLISON, A.C. Protection afforded by sickle-cell trait against subtertian malarial infection. Brit. Med. J., 1 (4857) :290-294, 1954.
3 BARNICOT, N.A.; ALLISON, A.C.; BLUMBERG, B.S.; DELIYANNIS, G.; KRIMBAS, C.; BALLAS, A. Haemoglobin types in Greek populations. Ann. Hum. Genet., 26:229-236, 1963.
4 BETKE, K.; MARTI, H.R.; SCHLICHT, I. Estimation of small percentages of foetal haemoglobin. Nature, London, 184(4702):1877-1878, 1959.
5 CROSBY, W.H. & CONRAD, M.E. Iron balance in thalassemia minor. A preliminary report. Ann. N.Y. Acad. Sci., 119:616-623, 1964.
6 DACIE, J.V. & LEWIS, S.M. Hematologia practica. 2. ed. Barcelona, Toray, 1970.
7 HALDANE, J.B.S. Disease and evolution. Ric. Sei., 19:68, 1949.
8 HEINRICH, H.C.; GABBE, E.E.; OPPITZ, K.H. Absorption of inorganic and food iron in children with heterozigous and homozygous
betathalassemia. Z. Kinderheilkd, 115: 1-22, 1973.
9 LAPPÉ, M.; GUSTAFSON, J.M.; ROBLIN, R. Ethical and social issues in screening for genetic disease. New Engl. J. Med., 286(21)1129-1132, 1972.
10 LIE-INJO, L.E.; LOPEZ, C.G.; HART, P.L. Erythrocyte carbonic anhydrase activity in health and disease. Clin. Chim. Acta, 29:541-550, 1970.
11 MALAMOS, B.; FESSAS, P.; STAMATOYANNOPOULOS, G. Types of thalassaemia-trait carriers as revealed by a study of their incidence in Greece. Brit. J. Haemat., 8(1):5-14, 1962.
12 MOTULSKY, A.G. Hereditary red cell traits and malaria. Amer. J. Trop. Med. Hyg., 13(1) 147-158, 1964.
13 MOTULSKY, A.G. Metabolic polymorphisms and the role of infectious diseases in human evolution. Hum. Biol., 32(1):28-62, 1960. 65
14 PEARSON, H.A.; O'BRIEN, R.T.; McINTOSH, S. Screening for thalassemia trait by electronic measurement of mean corpuscular volume. New Engl. J. Med., 288(7):351-353, 1973.
15 SILVESTRONI, E. & BIANCO, I. The distribution of microcythaemias (or thalassemias). In: JON%IS, J.H.P. & DELAFRESNAY, J.F., ed. Abnormal haemoglobin: a symposium. Oxford, Blackwell, 1959.
16 SINGER, K.; AMOZ, M.D.; CHERNOFF, M.D.; SINGER, L.M.S. Studies on abnormal haemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali desnaturation. Blood, 6(5): 413-428, 1951.
17 STEINER, J.; MARTI, H.R.; DEAN, D. Decreased hemoglobin Aa concentration in iron deficiency anemia. Acta Haemat., 45:77-81, 1971.
18 VANDEPITTE, J. & DELAISSE, J. Sicblémie et paludisme. Aperçu du problème et contribution personnelle. Ann. Soc. Beige Méd. Trop., 87(5): 703-735, 1957.
19 WASI, P.; DISTHASONGCHAN, P.; NA-NAKORN, S. The effect of iron deficiency on the levels of hemoglobins A2 and E. J. Lab. Clin. Méd., 71(1):85-91, 1968.
20 WEATHERALL, D.J. Los síndromes talassémicos. Barcelona, Toray, 1967.
21 WEHINGER, H. Untersuchungen über die Erythrociten-Carboanhydrasen bei pathologischen Zustanden in Kindesalten. Z. Kinderheilk, 114:163-174, 1973.
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