Determinação espectrofotométrica de eritromicina em medicamentos

Waldomiro Pregnolatto; Neusa Santesso Garrido

doi:10.53393/rial.1974.34.37057

Vol. 34 No. 1-2 (1974), ORIGINAL ARTICLE

Vol. 34 No. 1-2 (1974)

Spectrophotometric determination of erythromycin in pharmaceuticals

ORIGINAL ARTICLE

https://doi.org/10.53393/rial.1974.34.37057

Published 1974-12-30

Waldomiro Pregnolatto⁺⁻
Neusa Santesso Garrido⁺⁻

Waldomiro Pregnolatto

Instituto Adolfo Lutz

Neusa Santesso Garrido

Instituto Adolfo Lutz

pdf (Português (Brasil))

Keywords

erythromycin in pharmaceuticals, spectrophotometric determination
thin-layer chromatography to determine erythromycin

How to Cite

1.

Pregnolatto W, Garrido NS. Spectrophotometric determination of erythromycin in pharmaceuticals. Rev Inst Adolfo Lutz [Internet]. 1974 Dec. 30 [cited 2024 Jul. 3];34(1-2):47-51. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/37057

Abstract

A simple method to determine the dosage of erythromycin in pharmaceuticals is herein described. The method comprises the spectrophotometric detection at 540 nm of the compound resulting from a reaction between erythromycin and xanthydrol, in an acid medium. Theideal condition for the reaction to take place were established and the possibility of ínterference by some chemical element that might be found in mixture with the erythromycin contained in such pharmaceuticals were investigated. Recovery tests were made, Error rate method is around 2%. The necessary conditions for thin-layer chromatography separation and determination of erythromycin ant its salts when mixed with tetracyclin and espiramycin were als o established.

https://doi.org/10.53393/rial.1974.34.37057

pdf (Português (Brasil))

References

1. FORD, J.H.; PRESCOTT, G.C. HINMAN, J . W. & CARON, E. L. - Colorimetric determination of erythromycin. Analyt. Chem., 25 (8): 1195-7, 1953.

2. KAKEMI, K.; UNO, T. & YAMASHINA, H. - Chemical methods for the determination of antibiotics. VI. Colorimetric determination of erythromycin. J. Ptuirm , Soe. Japan, 76 (10): 1116-8, 1956 apud Analyt. Abstr., 4: 3104, 1957.

3. KORCHAGIN, V.B.; SEMENOV, S.M. & SA VUSHKINA, L. N. -
Colorimetric determination of erythromycin. Antibiotilci, 6 (4): 311-4, 1961 apud Analyt. Abstr, 8: 4818, 1961.

4. KUZEL, N. R.; WOODSIDE, J. M.; COMER, J . P. & KENNEDY, E. E. - Spectrophotometric determination of erythromycin in pharmaceutical products. Antibiot. & ctiernotner., 4 (12): 1234-41, 1954 apud Analyt. Abstr., 2: 1308, 1955.

5. OCHAB, S.; MAL YZS, D. & BOROWIECKA, B. - Determination of erythromycin ín the presence of tetracycline in pharmaceuticals. Chem. Anal., Warsaw, 8 (4): 597-600, 1963 apud Analyt. Abstr., 11: 3926, 1964.

6. PESEZ, M. - Colorimetric determination of erythromycin by means of methylsulphate. Ann. Ptuirm, Franç., 13 (7-8): 513-6, 1955 apud Analyt. Abstr., 3: 1857, 1956.

7. TEPE, J.B. & ST. JOHN, C.V. - Determina tion of erythromycin by ul tra violet spectrophotometry. Analyt. Chem., 27 (5): 744-6, 1955.

8. WASHBURN, W.H. - The infra-red determination of erythromycin. J. Amer. Pharm. Ass. Sei. Ed. 43 (1): 48-9, 1954 apud Analyt. Abstr., 1: 1632, 1954.

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