Anticorpos antipolissacarídeo de Neisseria meningitidis grupos A e C, em vacinados e em pacientes com doença meningocócica previamente vacinados ou não

Augusta Kiyomi Takeda; Vinício Carlos Rossi; José Manoel de Paiva Diniz; Maria das Graças Fernandes Adelino; Augusto Taunay

doi:10.53393/rial.1975.35.37085

, ORIGINAL ARTICLE

Antibodies to polysaccharide of Neisseria meningitidis, serogroups A and C in normal vaccinated persons and in paiients with meningococcal diseases previously vaccinated or not

ORIGINAL ARTICLE

https://doi.org/10.53393/rial.1975.35.37085

Published 1976-12-30

Augusta Kiyomi Takeda⁺⁻
Vinício Carlos Rossi⁺⁻
José Manoel de Paiva Diniz⁺⁻
Maria das Graças Fernandes Adelino⁺⁻
Augusto Taunay⁺⁻

Augusta Kiyomi Takeda

Instituto Adolfo Lutz

Vinício Carlos Rossi

Hospital Infantil Cândido Fontoura, São Paulo, SP

José Manoel de Paiva Diniz

Instituto Adolfo Lutz

Maria das Graças Fernandes Adelino

Instituto Adolfo Lutz

Augusto Taunay

Instituto Adolfo Lutz

pdf (Português (Brasil))

Keywords

Neisseria meningitidis, serogroups A and C
meningitis, meningoooccic
vaccine, meningococcaI polysaccharide

How to Cite

1.

Takeda AK, Rossi VC, Diniz JM de P, Adelino M das GF, Taunay A. Antibodies to polysaccharide of Neisseria meningitidis, serogroups A and C in normal vaccinated persons and in paiients with meningococcal diseases previously vaccinated or not. Rev Inst Adolfo Lutz [Internet]. 1976 Dec. 30 [cited 2024 Jul. 23];35(1-2):139-46. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/37085

Abstract

The response to the antigenic stimulus of meníngococcic polysaccharide vaccine was evaIuated through passive haemaggIutination in individuaIs in the age group of O to older than 21 years old, Vaccine A was found to be more immunogenic than vaccine C. No cross reactíons were found between A and C polysaccharídes, The reaction proved to be specífíc for both groups of meningococcus, thus allowing correct diagnosis of meningococcíc dísease in many ínstances where other diagnostic test have faíled. The passíve haemagglutination was inefective as a díagnostícal test in patíents who had been vaccinated with AC antimeníngococcíc vaccine, because most of these patíents presented low haemagglutinating títles without serologícal conversion and, when it was present, It was not possible to know weather it was due do the vaccine or to the descase.

https://doi.org/10.53393/rial.1975.35.37085

pdf (Português (Brasil))

References

1. CARBONARE, S.B.; TAKEDA, A.K. JORDAO, F.B.M. & TAUNAY, A.E. - Especificidade imunológica dos polissacarídeos extraídos de diferentes grupos de Neisseria meningitidis. Rev. Inst. Adolfo Lutz, 34: 119-25, 1974.

2. COHEN, R.L. & ARTENSTEIN, M.S. Hemagglutination inhibition for seregrouping of Neisseria meningitidis. Appl. Microbiol., 23: 289-92, 1972.

3. EDWARDS, E.A. & DRISCOLL, W.S. Group-specific hemagglutination test for Neisseria meningitidis antibodies. Proc , Soc. exp. Biol. teea., 126: 876-9, 1967.

4., EICKHOFF, T. C. Sero-epidemiologic studies of meningococcal infection with the indirect hemagglutination test. J. infect, Dis., 123 (5): 519-26, 1971.

5. HAMMOND, B.W.; KINGSBURY, D.T. & WEISS, E. - Modification of meníngocoe cal polysaccharide antigens for use in passive hemagglutination tests. J. Immun., 101: 808-9, 1968.

6. HUNTLEY, B. & REED, D. - A'n indirect hemagglutination test for group B meningococcus. Am. J. Epidem. 86: 142-8, 1967.

7. JONES, D.M. & TOBION, D.M. - Incidence of hemagglutination antibodies to meningococci in North-West England. J. clin. Path., 25: 955-8, 1972.

8. ROSSI, V.C.; DINIZ, J.M.P.; ADELINO, M.G.F.; TAKEDA, A.K.; TAUNAY, A. E. & CANDIO, S. - Resposta humoral aos polissacarídeos obtidos da N. meningitidis dos grupos A e C utilizados na vacinação e revacinação antimeningocócíca. Rev. Inst. Adolfo Lutz, 37, 1977. [No prelo]

9. SANBORN, W. R. & VEDROS, N. A. - Possibilities of aplication of complement fluorescent antibody test to epidemíology
fixation, indirect hemagglutination and of meningococcal infection. Hlth. Lab. Sei., 3: 311-7, 1966.

10. TAKEDA, A.K. TAUNAY, A. E. SCALABRINI, L.G.P. & CASTRO, I.0. - Anticorpos antipolissacarídeo C de Neisserie meningitidis: detecção através da hemaglutinação passiva em soros de pacientes e de vacinados. Rev. Inst. Adolfo Lutz, 34: 127-33, 1974.