Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients

Autores

  • Fabiana Covolo de Souza Pesquisador Científico- ILSL- Bauru- SP.
  • Elaine Valim Camarinha Marcos Pesquisador Científico- ILSL- Bauru- SP.
  • Somei Ura Pesquisador Científico e Diretor da Divisão de Pesquisa e Ensino – ILSL-Bauru-SP.
  • Maria Esther Sales Nogueira Pesquisador Científico e Diretor da Divisão de Pesquisa e Ensino – ILSL-Bauru-SP.

DOI:

https://doi.org/10.47878/hi.2010.v35.35121

Palavras-chave:

Leprosy, HLA, Lepromin, Mycobacterium leprae

Resumo

The purpose of this study was to identify the gene encoding HLA-DQ1 involved in the absence of cellular immune response in 60 Mitsuda negative leprosy patients (50LL and 10BL). The results showed the presence of HLA-DQB1*0501 in 48.30% of patients, followed by HLA-DQB1*0602 in 31.66%, both subtypes of the phenotype HLA-DQB1*01. Despite the prevalence of these alleles, we can not say that they are responsible for the lack of response to the Mitsuda antigen. We suggest further studies to confirm the results.

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Publicado

30-06-2010

Como Citar

1.
Souza FC de, Marcos EVC, Ura S, Nogueira MES. Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients. Hansen. Int. [Internet]. 30º de junho de 2010 [citado 7º de dezembro de 2022];35(1):41-4. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121

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