Keywords
Leprosy
Neoplasms, Nerve Tissue
How to Cite
Abstract
From December 1999 to May 2015, five patients with nerve tumors were sent to Lauro de Souza Lima Institute. It was suspected that they suffered from primary neural leprosy towards the tuberculoid clinical form, a prevalence of 4.5:10000 among the new patients assessed during the study period. All of the patients had similar clinical conditions characterized by mononeuropathy with nerve tumor associated with pain, absence of skin lesions and positive Mitsuda reaction. The authors report the main clinical characteristics and complementary tests: immunologic investigation of Mitsuda’s reaction and the antigen Phenolic GlicoLipid-1 test (PGL-1), bacilloscopic index, neurophysiologic study and image procedures. All patients were submitted to tumor resection and anatomopathological study. Four out of the five patients were diagnosed with peripheral nerve tumor (one of them with malignant schwannoma, two of them with benign schwannomas and the other with neural fibrolipoma), whereas the fifth patient was diagnosed with tuberculoid leprosy
References
2. Souza JF, Toledo LL, Ferreira MCM, Rodrigues LOC, Rezende NA. Neurofibromatose tipo 1: mais comum e grave do que se imagina. Rev Assoc Med Bras [Internet]. 2009 [cited 2018 Abr 10];55(4):394-9. Available from: https://www.scielo.br/pdf/ramb/v55n4/a12v55n4.pdf.
3. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: International Agency for Research on Cancer; 2013.
4. Garbino JA, Marques W Jr, Barreto JA, Heise CO, Rodrigues MMJ, Antunes SL et al. Primary neural leprosy: systematic review. Arq Neuro-Psiquiatr. 2013;71(6):397-404.doi: https://doi.org/10.1590/0004-282X20130046.
5. Santos DF. Aspectos clínicos, moleculares, sorológicos e neurofisiológicos no diagnóstico precoce da neuropatia hansênica [tese]. Uberlândia: Universidade Federal de Uberlândia, Faculdade de Medicina; 2017.
6. Ridley DS, Jopling WH. Classification of leprosy according to immunity (A five-group sistem). Int. J. Lepr [Internet]. 1966 [cited 2018 Abr 10];54(3):255-73. Available from: http://ila.ilsl.br/pdfs/v34n3a03.pdf.
7. Magalhães MJS, Fujioka AJ, Chaves RB. Schwannoma as a cause of Carpal Tunnel Syndrome: a case report. Arq. Bras. Neurocir. 2015;34:309-12. doi:https://doi.org/10.1055/s-0035-1564828.
8. Soares PBN, Marangon LC, Leal RM, Capistrano HM, Marigo HA. Neurilemmoma: a case report. Rev Odontol Bras Central [Internet]. 2012 [cited 2018 Abr 10];21(56):458-61. Available from: http://files.bvs.br/upload/S/0104-7914/2012/v21n56/a3153.pdf.
9. Lorenzoni PJ, Lange MC, Kamoi Kay, CS, Silvado CE, Scola RH, Werneck LC. Fibrolipomatous hamartoma of the median nerve: case report. Arq Neuro-Psiquiatr. 2005;63(3b):881-4. doi: https://doi.org/10.1590/S0004-282X2005000500033.
10. Pineda RM, Rabello CF, Barbosa LA, Bortoline CM, Cintra LC. Malignant peripheral nerve sheath tumor: case report and review of the literature. Rev. Bras. Cancerol. 2001;47(4):435-9.
11. Diogo CJ, Formigo A, Florova E, Fernandes C, Fonte L, Vieira MJM, et al. Malignant peripheral nerve sheath tumor: case report. Rev Bras Clin Med [Internet]. 2012 [cited 2018 Abr 10];10(1):69-72. Available from: http://www.sbcm.org.br/revistas/HTML/RBCM_v10_n1/conteudo.php?artigo=13
12. Garbino JA. The patient with suspicion of primarily neural leprosy. Hansen Int [Internet]. 2007 [cited 2018 Abr 10];32(2):203-6. Available from: http://www.ilsl.br/revista/detalhe_artigo.php?id=10747.
This journal is licensed under a Creative Commons Attribution 4.0 International License.
Downloads
