Efetividade da vitamina E sobre o estresse oxidativo, em hansenianos da forma multibacilar sob tratamento

Luiz Fernando Rimoli; Moacir Fernades Godoy

doi:10.47878/hi.2011.v36.35109

Authors

Luiz Fernando Rimoli Doutor em Medicina Interna. Docente no Centro Universitário da Fundação Educacional de Barretos – SP. Professor de Fisiologia nos Cursos de Graduação em Odontologia e Farmácia e Professor de Fisiologia e Emergências Médicas no Curso de Especialização em Endodontia.
Moacir Fernades Godoy Livre docente. Membro dos Departamentos de Cardiologia e Cirurgia Cardiovascular, Epidemiologia e Saúde Coletiva da Faculdade de Medicina de São José do Rio Preto – SP.

DOI:

https://doi.org/10.47878/hi.2011.v36.35109

Keywords:

vitamin E, oxidative stress, leprosy

Abstract

INTRODUCTION: Leprosy is a chronic contagious infectious disease caused by Mycobacterium leprae, and has not been wiped out in Brazil, which currently ranks second in the absolute number of cases, second only to India. The disease is not leprosy causes oxidative stress, but the therapy used. Several studies show the reduction of oxidative stress in different pathology, the use of vitamin E. In leprosy, however, the literature is scarce about this effect. OBJECTIVE: The aim of this study was the reduction by vitamin E, oxidative stress caused by the use of dapsone, rifampicin and clofazimine for treating leprosy patients, the multibacillary form. PATIENTS AND METHODS: We reviewed the previous presence of oxidative stress in 32 leprosy patients, the multibacillary form, through blood tests and then the patients were divided into two groups randomly, with 16 patients in each group, namely: groups with vitamin E “and” control “. Patients in the group with vitamin E “made use of 800 IU / day orally, vitamin E and” control “group did not use vitamin supplement. After 30, 60 and 90 days of treatment, blood samples were collected from two groups to determine the concentration of methemoglobin and the presence of Heinz bodies. RESULTS: The results were subjected to statistical test Chi-square (χ2). No difference was found between the two groups. CONCLUSION: We conclude that vitamin E dose and duration of treatments, does not confer a protective effect against oxidative stress caused by dapsone, rifampicin and clofazimine used by patients with multibacillary leprosy.

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