CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY

Authors

  • B. BEIGUELMAN Department of Medical Genetics, State University of Campinas, SP, Brasil.
  • R. C. B. PISANI Department of Medical Genetics, State University of Campinas, SP, Brasil.

DOI:

https://doi.org/10.47878/hi.1976.v1.35675

Keywords:

Hanseniasis, Therapy, Dapsone, Genetics, Chromosome analysis, Chromosomal aberrations

Abstract

Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood.

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References

1. BEIGUELMAN, B.; MARCHI, A.; HAMA, T.; AMIN, C.C.; GODOI, M. N. C.; BAPTISTA, T. A. Fecundidade e lepra. Rev. Paul. Med., 66(4) : 207-213, 1965.
2. BEIGUELMAN, B.; PINTO JR., W.; EL-GUINDY, M. M.; KRIEGER, H. Factors influencing the level of dapsone in blood. Bull. World Health Organ., 51 :467-471, 1974.
3. BEIGUELMAN, B.; PISANI, R. C. B.; EL-GUINDY, M. M. In vitro effect of DDS on human chromosomes. Int. J. Leprosy, 48(1):41-44, 1975.
4. BLOOM, A. D. Induced chromosomal aberrations in man. In: HARRIS, H. & HIRSCHHORN, K., ed. Advances in human genetics. New York, Plenum Press, 1972. cap. 3, p. 99-172.
5. BLOOM, A. D.; NEEL, J. V.; TSUCHIMOTO, T.; MEILINGER, K. Chromosomal breakage in leukocytes of South American Indians. Cytogenetics, 12:175-186, 1973.
6. COURT-BROWN, W. M. Human population cytogenetics. Amsterdam, North- Holland Publ., 1967. 107p.
7. LUBS, H. A. & SAMUELSON, H. A. Chromosome abnormalities in lymphocytes from normal human subjects. Cytogenetics, 6:402-411, 1967.
8. MOLESWORTH, B. D.; NARAYANASWAMI, P. S.; SIMPSON, I. A. The treatment of lepromatous leprosy with 4:4'-Diaminodiphenyl sulfone in oil: findings in 100 cases treated for one year, with a note on the technique of sulfone determinations. Int. J. Leprosy, 17(3) :197-210, 1949.
9. NICHOLS, W. W. Virus-induced chromosome abnormalities. Ann. Rev. Microbiol., 24:479-500, 1970.
10. RABELLO, M.N. Estudo citogenético de indivíduos profissionalmente expostos ao DDT. São Paulo, 1974. 142p. [Tese-Universidade de São Paulo]

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Published

1976-06-30

How to Cite

1.
BEIGUELMAN B, PISANI RCB. CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY . Hansen. Int. [Internet]. 1976 Jun. 30 [cited 2024 Jul. 22];1(1):53-60. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675

Issue

Vol. 1 No. 1 (1976)

Section

Artigos de investigação científica

License

This journal is licensed under a Creative Commons Attribution 4.0 International License.