CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY
Vol. 1 Núm. 1 (1976), Artigos de investigação científica
Vol. 1 Núm. 1 (1976)

CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY

Artigos de investigação científica
https://doi.org/10.47878/hi.1976.v1.35675
Publicado 1976-06-30
B. BEIGUELMAN
Department of Medical Genetics, State University of Campinas, SP, Brasil.
R. C. B. PISANI
Department of Medical Genetics, State University of Campinas, SP, Brasil.
PDF (Português (Brasil))

Palabras clave

Hanseniasis
Therapy
Dapsone
Genetics
Chromosome analysis
Chromosomal aberrations

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1.
BEIGUELMAN B, PISANI RCB. CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY . Hansen. Int. [Internet]. 30 de junio de 1976 [citado 24 de noviembre de 2024];1(1):53-60. Disponible en: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35675
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Resumen

Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood.

https://doi.org/10.47878/hi.1976.v1.35675
PDF (Português (Brasil))

Citas

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8. MOLESWORTH, B. D.; NARAYANASWAMI, P. S.; SIMPSON, I. A. The treatment of lepromatous leprosy with 4:4'-Diaminodiphenyl sulfone in oil: findings in 100 cases treated for one year, with a note on the technique of sulfone determinations. Int. J. Leprosy, 17(3) :197-210, 1949.
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