Keywords
Hanseniasis
Machophages
Genetics
Mycobacterium leprae
Machophages
Genetics
Mycobacterium leprae
How to Cite
1.
Freire-Mata DV. Analise familial do comportamento in vitro dos macrófagos humanos frente ao Mycobacterium leprae. Hansen. Int. [Internet]. 1983 Nov. 30 [cited 2024 Oct. 31];8(2):91-100. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36134
Abstract
The lysogenic capacity of human macrophages facing M. leprae in vitro may be dependent on an important genetic component. Although the family aggregation of the trait is demonstrated, this is a necessary but not sufficient condition to prove genetic influence. The data do not fit some simple genetic models (autosomal dominant or incompletely dominant gene; dominant or recessive sex-linked gene). The results obtained are consistent with the hypothesis that the macrophages' lysogenic capacity is mainly due to a major gene with variable expressivity. This hypothesis may be too simple to account for the whole variability detected and therefore must be considered just as a working hypothesis.
References
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2 BEIGUELMAN, B. An appraisal of genetic studies on leprosy. Acta Genet. Med. Gemellol., 21 :21-52, 1972.
3 BEIGUELMAN, B. Dinâmica dos genes nas populações e nas famílias. São Paulo, Edart, 1968. 212p.
4 BEIGUELMAN, B. Further results on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF
HUMAN GENETICS, 3., Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.
5 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência it lepra. Cien.
Cult., 17(4) :449-460, 1965.
6 BEIGUELMAN, B. The genetics of resistance to leprosy. Int. J. Lepr., 33 (4) :808-812, 1965.
7 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
8 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese — Faculdade de Medicina de Ribeirão
Preto]
9 BEIGUELMAN, B. Lepra e genética. Cien. Cult., 34:1121-1146, 1982.
10 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin pair analysis. Acta Leprol., (44) :5-65, 1971.
11 BEIGUELMAN, B. Leprosy and genetics: a review of past research with remarks concerning future investigations. Bull. Wld. Hlth. Org., 87: 461-476, 1967.
12 BEIGUELMAN, B. Sistema ABO e epidemiologia da lepra. Rev. Paul. Med., 65(2) :80-86, 1964.
13 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., 17(4) :
584-594, 1968.
14 BEIGUELMAN, B.; DALL'AGLIO, F.F.; SILVA, E. Estudo das formas polares de lepra pela análise de pares de
irmãos. Rev. Paul. Med. , 72(3) : 111-119, 1968.
15 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
16 BENEWOLENSKAJA, S.W. Ober die in-vitro-Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
17 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp., Immunol., 86(2) :214-220, 1979.
18 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
19 DE VRIES, R.R.P.; FAT, R.F.M.L.A.; NIJENHUIS, L.E.; VAN ROOD, J.J. HLA-linked genetic control of host
response to Mycobacterium leprae. Lancet, 2:1328-1330, 1976.
20 FAYE, I.; RUSHER, H.; TSALA, M.P.; BLOC, G. Lèpre at groupe sanguin à Dakar. Bull. Soc. Med. Afr. Noire Langue Franc., 16(4) :551-553, 1971.
21 FREIRE-MAIA, D.V. Comportamento in vitro dos macrófagos humanos frente ao M. leprae. Estudo em pessoas sadias e pacientes com hanseníase virchoviana e tuberculóide. Hansen. Int., 8 (2) :81-90, 1983.
22 GOEDDE, H.W.; BENKMANN, H.G.; HIRTH, L.; ROHDE, R.; ROUGEMONT, A.; DELBRUCK, H. Phenotypes
of Gc and Tf in leprosy patients of Mali and Ethiopia. Hum. Hered., 24:383-386, 1975.
23 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15: 48-64, 1947.
24 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15(1) :31-47, 1947.
25 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr., 15(1) :21-30,
1947.
26 LANGUILLON, J.; LINHARD, J.; DIEBOLT, G. Groupes sanguins: hémoglobines anormales et lèpre. Bull.
Soc. Med. Afr. Noire Langue Franc., 16(4) :581-584, 1971.
27 LECHAT, M.F.; BIAS, W.B.; GUINTO, R.S.; COHEN, B.H.; TOLENTINO, J.G.; ABALOS, R.M. A study of various blood group systems in leprosy patients and controls in Cebu, Philippines. Int. J. Lepr., 36(1) : 17-31, 1968.
28 MORTON, N.E.; LEW, R.; HUSSELS, I.E.; LITTLE, G.F. Pingelap and Mokie Atolls: historical genetics. Amer. J. Hum.-Genet., 24:277-289, 1972.
29 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1):14-24, 1973.
30 REA, T.H. & TERESAK, P.I. HLA-DR antigens in tuberculoid and lepromatous leprosy. Lepr. Rev., 51(2) :117-123, 1980.
31 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and
classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97,
1937.
32 SALZANO, F.M.; SURE, M.V.; FERLAUTO, M. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17:530-544, 1967.
33 SCHWANTES, A.R.; SALZANO, F.M.; CASTRO, I.V.; TONDO, C.V. Haptoglobins and leprosy. Acta Genet. (Basel), 17:127-136, 1967.
34 SERJEANTSON, S.; WILSON, S.R.; KEATS, B.J.B. The genetics of leprosy. Ann. Hum. Biol., 6:375-393, 1979.
35 SMITH, D.G. The genetics hypothesis for susceptibility to lepromatous leprosy. Hum. Genet., 50(2) :163-177, 1979.
36 SPICKETT, S.G. Genetics and the epidemiology of leprosy. I. The incidence of leprosy. Lepr. Rev., 33(2):76-93,
1962.
37 SPICKETT, S.G. Genetics and the epidemiology of leprosy. II. The form of leprosy. Lepr. Rev., 34(3) :173-181,
1962.
38 SPIELMANN, W.; TEIXIDOR, D.; RENNINGER, W.; MATZNETTER, T. Blutgruppen and Lepra bei Moçambiquanischen Volkerschaften. Human genetik, 10(4):304-317, 1970.
39 VOGEL, T. ABO blood groups and leprosy. J. Med. Genet., 5:56-57, 1968.
40 WAL TER, H. ; BAJATZADEH, M. ; KELLERMANN, G. ; MATZNETTER, T. Associations between leprosy and serum protein groups. Humangenetik, 10:298-303, 1970.
41 YOUNGCHAIYUD, U. ; CHANDANAYINGYONG, D.; VIBHATAVAN IJA, T. The incidence of HLA antigens in leprosy. Vox Sang., 32(6):342-345, 1977.
2 BEIGUELMAN, B. An appraisal of genetic studies on leprosy. Acta Genet. Med. Gemellol., 21 :21-52, 1972.
3 BEIGUELMAN, B. Dinâmica dos genes nas populações e nas famílias. São Paulo, Edart, 1968. 212p.
4 BEIGUELMAN, B. Further results on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF
HUMAN GENETICS, 3., Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.
5 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência it lepra. Cien.
Cult., 17(4) :449-460, 1965.
6 BEIGUELMAN, B. The genetics of resistance to leprosy. Int. J. Lepr., 33 (4) :808-812, 1965.
7 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
8 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese — Faculdade de Medicina de Ribeirão
Preto]
9 BEIGUELMAN, B. Lepra e genética. Cien. Cult., 34:1121-1146, 1982.
10 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin pair analysis. Acta Leprol., (44) :5-65, 1971.
11 BEIGUELMAN, B. Leprosy and genetics: a review of past research with remarks concerning future investigations. Bull. Wld. Hlth. Org., 87: 461-476, 1967.
12 BEIGUELMAN, B. Sistema ABO e epidemiologia da lepra. Rev. Paul. Med., 65(2) :80-86, 1964.
13 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., 17(4) :
584-594, 1968.
14 BEIGUELMAN, B.; DALL'AGLIO, F.F.; SILVA, E. Estudo das formas polares de lepra pela análise de pares de
irmãos. Rev. Paul. Med. , 72(3) : 111-119, 1968.
15 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
16 BENEWOLENSKAJA, S.W. Ober die in-vitro-Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
17 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp., Immunol., 86(2) :214-220, 1979.
18 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
19 DE VRIES, R.R.P.; FAT, R.F.M.L.A.; NIJENHUIS, L.E.; VAN ROOD, J.J. HLA-linked genetic control of host
response to Mycobacterium leprae. Lancet, 2:1328-1330, 1976.
20 FAYE, I.; RUSHER, H.; TSALA, M.P.; BLOC, G. Lèpre at groupe sanguin à Dakar. Bull. Soc. Med. Afr. Noire Langue Franc., 16(4) :551-553, 1971.
21 FREIRE-MAIA, D.V. Comportamento in vitro dos macrófagos humanos frente ao M. leprae. Estudo em pessoas sadias e pacientes com hanseníase virchoviana e tuberculóide. Hansen. Int., 8 (2) :81-90, 1983.
22 GOEDDE, H.W.; BENKMANN, H.G.; HIRTH, L.; ROHDE, R.; ROUGEMONT, A.; DELBRUCK, H. Phenotypes
of Gc and Tf in leprosy patients of Mali and Ethiopia. Hum. Hered., 24:383-386, 1975.
23 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15: 48-64, 1947.
24 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15(1) :31-47, 1947.
25 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr., 15(1) :21-30,
1947.
26 LANGUILLON, J.; LINHARD, J.; DIEBOLT, G. Groupes sanguins: hémoglobines anormales et lèpre. Bull.
Soc. Med. Afr. Noire Langue Franc., 16(4) :581-584, 1971.
27 LECHAT, M.F.; BIAS, W.B.; GUINTO, R.S.; COHEN, B.H.; TOLENTINO, J.G.; ABALOS, R.M. A study of various blood group systems in leprosy patients and controls in Cebu, Philippines. Int. J. Lepr., 36(1) : 17-31, 1968.
28 MORTON, N.E.; LEW, R.; HUSSELS, I.E.; LITTLE, G.F. Pingelap and Mokie Atolls: historical genetics. Amer. J. Hum.-Genet., 24:277-289, 1972.
29 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1):14-24, 1973.
30 REA, T.H. & TERESAK, P.I. HLA-DR antigens in tuberculoid and lepromatous leprosy. Lepr. Rev., 51(2) :117-123, 1980.
31 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and
classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97,
1937.
32 SALZANO, F.M.; SURE, M.V.; FERLAUTO, M. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17:530-544, 1967.
33 SCHWANTES, A.R.; SALZANO, F.M.; CASTRO, I.V.; TONDO, C.V. Haptoglobins and leprosy. Acta Genet. (Basel), 17:127-136, 1967.
34 SERJEANTSON, S.; WILSON, S.R.; KEATS, B.J.B. The genetics of leprosy. Ann. Hum. Biol., 6:375-393, 1979.
35 SMITH, D.G. The genetics hypothesis for susceptibility to lepromatous leprosy. Hum. Genet., 50(2) :163-177, 1979.
36 SPICKETT, S.G. Genetics and the epidemiology of leprosy. I. The incidence of leprosy. Lepr. Rev., 33(2):76-93,
1962.
37 SPICKETT, S.G. Genetics and the epidemiology of leprosy. II. The form of leprosy. Lepr. Rev., 34(3) :173-181,
1962.
38 SPIELMANN, W.; TEIXIDOR, D.; RENNINGER, W.; MATZNETTER, T. Blutgruppen and Lepra bei Moçambiquanischen Volkerschaften. Human genetik, 10(4):304-317, 1970.
39 VOGEL, T. ABO blood groups and leprosy. J. Med. Genet., 5:56-57, 1968.
40 WAL TER, H. ; BAJATZADEH, M. ; KELLERMANN, G. ; MATZNETTER, T. Associations between leprosy and serum protein groups. Humangenetik, 10:298-303, 1970.
41 YOUNGCHAIYUD, U. ; CHANDANAYINGYONG, D.; VIBHATAVAN IJA, T. The incidence of HLA antigens in leprosy. Vox Sang., 32(6):342-345, 1977.
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