Palabras clave
Hanseníase
Macrófagos
Genética
Mycobacterium Ieprae
Macrófagos
Genética
Mycobacterium Ieprae
Cómo citar
1.
Freire-Mata DV. Analise familial do comportamento in vitro dos macrófagos humanos frente ao Mycobacterium leprae. Hansen. Int. [Internet]. 30 de noviembre de 1983 [citado 23 de noviembre de 2024];8(2):91-100. Disponible en: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36134
Resumen
A análise genética do comportamento dos macrófagos face ao M. Ieprae foi discutida, confrontando-se os resultados obtidos com as indicações que favorecem a hipótese de ser a capacidade lisogênica dos macrófagos frente ao M. Ieprae dependente de um componente genético importante. Foi demonstrada a existência de familiaridade do caráter, mas os dados não se conformam com alguns modelos genéticos simples (gene autossômico, dominante ou incompletamente dominante; e gene ligado ao sexo, dominante ou recessivo). Os dados não contrariam a hipótese de a capacidade lisogênica dos macrófagos ser condicionada por um gene principal, autossômico e recessivo, com expressividade variável, mas essa hipótese, por ser muito simplista para explicar a variabilidade existente na capacidade de lise dos diferentes indivíduos, deve ser considerada com reservas.
Citas
1 ANANTHAKRISHNAN, R.; WALTER, H. ; KELLERMANN, G. ; MATZNETTER, T. Further studies on associations between leprosy and genetic markers in human serum. Hum. Genet., 19:183-192, 1973.
2 BEIGUELMAN, B. An appraisal of genetic studies on leprosy. Acta Genet. Med. Gemellol., 21 :21-52, 1972.
3 BEIGUELMAN, B. Dinâmica dos genes nas populações e nas famílias. São Paulo, Edart, 1968. 212p.
4 BEIGUELMAN, B. Further results on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF
HUMAN GENETICS, 3., Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.
5 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência it lepra. Cien.
Cult., 17(4) :449-460, 1965.
6 BEIGUELMAN, B. The genetics of resistance to leprosy. Int. J. Lepr., 33 (4) :808-812, 1965.
7 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
8 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese — Faculdade de Medicina de Ribeirão
Preto]
9 BEIGUELMAN, B. Lepra e genética. Cien. Cult., 34:1121-1146, 1982.
10 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin pair analysis. Acta Leprol., (44) :5-65, 1971.
11 BEIGUELMAN, B. Leprosy and genetics: a review of past research with remarks concerning future investigations. Bull. Wld. Hlth. Org., 87: 461-476, 1967.
12 BEIGUELMAN, B. Sistema ABO e epidemiologia da lepra. Rev. Paul. Med., 65(2) :80-86, 1964.
13 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., 17(4) :
584-594, 1968.
14 BEIGUELMAN, B.; DALL'AGLIO, F.F.; SILVA, E. Estudo das formas polares de lepra pela análise de pares de
irmãos. Rev. Paul. Med. , 72(3) : 111-119, 1968.
15 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
16 BENEWOLENSKAJA, S.W. Ober die in-vitro-Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
17 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp., Immunol., 86(2) :214-220, 1979.
18 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
19 DE VRIES, R.R.P.; FAT, R.F.M.L.A.; NIJENHUIS, L.E.; VAN ROOD, J.J. HLA-linked genetic control of host
response to Mycobacterium leprae. Lancet, 2:1328-1330, 1976.
20 FAYE, I.; RUSHER, H.; TSALA, M.P.; BLOC, G. Lèpre at groupe sanguin à Dakar. Bull. Soc. Med. Afr. Noire Langue Franc., 16(4) :551-553, 1971.
21 FREIRE-MAIA, D.V. Comportamento in vitro dos macrófagos humanos frente ao M. leprae. Estudo em pessoas sadias e pacientes com hanseníase virchoviana e tuberculóide. Hansen. Int., 8 (2) :81-90, 1983.
22 GOEDDE, H.W.; BENKMANN, H.G.; HIRTH, L.; ROHDE, R.; ROUGEMONT, A.; DELBRUCK, H. Phenotypes
of Gc and Tf in leprosy patients of Mali and Ethiopia. Hum. Hered., 24:383-386, 1975.
23 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15: 48-64, 1947.
24 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15(1) :31-47, 1947.
25 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr., 15(1) :21-30,
1947.
26 LANGUILLON, J.; LINHARD, J.; DIEBOLT, G. Groupes sanguins: hémoglobines anormales et lèpre. Bull.
Soc. Med. Afr. Noire Langue Franc., 16(4) :581-584, 1971.
27 LECHAT, M.F.; BIAS, W.B.; GUINTO, R.S.; COHEN, B.H.; TOLENTINO, J.G.; ABALOS, R.M. A study of various blood group systems in leprosy patients and controls in Cebu, Philippines. Int. J. Lepr., 36(1) : 17-31, 1968.
28 MORTON, N.E.; LEW, R.; HUSSELS, I.E.; LITTLE, G.F. Pingelap and Mokie Atolls: historical genetics. Amer. J. Hum.-Genet., 24:277-289, 1972.
29 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1):14-24, 1973.
30 REA, T.H. & TERESAK, P.I. HLA-DR antigens in tuberculoid and lepromatous leprosy. Lepr. Rev., 51(2) :117-123, 1980.
31 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and
classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97,
1937.
32 SALZANO, F.M.; SURE, M.V.; FERLAUTO, M. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17:530-544, 1967.
33 SCHWANTES, A.R.; SALZANO, F.M.; CASTRO, I.V.; TONDO, C.V. Haptoglobins and leprosy. Acta Genet. (Basel), 17:127-136, 1967.
34 SERJEANTSON, S.; WILSON, S.R.; KEATS, B.J.B. The genetics of leprosy. Ann. Hum. Biol., 6:375-393, 1979.
35 SMITH, D.G. The genetics hypothesis for susceptibility to lepromatous leprosy. Hum. Genet., 50(2) :163-177, 1979.
36 SPICKETT, S.G. Genetics and the epidemiology of leprosy. I. The incidence of leprosy. Lepr. Rev., 33(2):76-93,
1962.
37 SPICKETT, S.G. Genetics and the epidemiology of leprosy. II. The form of leprosy. Lepr. Rev., 34(3) :173-181,
1962.
38 SPIELMANN, W.; TEIXIDOR, D.; RENNINGER, W.; MATZNETTER, T. Blutgruppen and Lepra bei Moçambiquanischen Volkerschaften. Human genetik, 10(4):304-317, 1970.
39 VOGEL, T. ABO blood groups and leprosy. J. Med. Genet., 5:56-57, 1968.
40 WAL TER, H. ; BAJATZADEH, M. ; KELLERMANN, G. ; MATZNETTER, T. Associations between leprosy and serum protein groups. Humangenetik, 10:298-303, 1970.
41 YOUNGCHAIYUD, U. ; CHANDANAYINGYONG, D.; VIBHATAVAN IJA, T. The incidence of HLA antigens in leprosy. Vox Sang., 32(6):342-345, 1977.
2 BEIGUELMAN, B. An appraisal of genetic studies on leprosy. Acta Genet. Med. Gemellol., 21 :21-52, 1972.
3 BEIGUELMAN, B. Dinâmica dos genes nas populações e nas famílias. São Paulo, Edart, 1968. 212p.
4 BEIGUELMAN, B. Further results on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF
HUMAN GENETICS, 3., Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.
5 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência it lepra. Cien.
Cult., 17(4) :449-460, 1965.
6 BEIGUELMAN, B. The genetics of resistance to leprosy. Int. J. Lepr., 33 (4) :808-812, 1965.
7 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
8 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese — Faculdade de Medicina de Ribeirão
Preto]
9 BEIGUELMAN, B. Lepra e genética. Cien. Cult., 34:1121-1146, 1982.
10 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin pair analysis. Acta Leprol., (44) :5-65, 1971.
11 BEIGUELMAN, B. Leprosy and genetics: a review of past research with remarks concerning future investigations. Bull. Wld. Hlth. Org., 87: 461-476, 1967.
12 BEIGUELMAN, B. Sistema ABO e epidemiologia da lepra. Rev. Paul. Med., 65(2) :80-86, 1964.
13 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., 17(4) :
584-594, 1968.
14 BEIGUELMAN, B.; DALL'AGLIO, F.F.; SILVA, E. Estudo das formas polares de lepra pela análise de pares de
irmãos. Rev. Paul. Med. , 72(3) : 111-119, 1968.
15 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
16 BENEWOLENSKAJA, S.W. Ober die in-vitro-Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
17 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp., Immunol., 86(2) :214-220, 1979.
18 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
19 DE VRIES, R.R.P.; FAT, R.F.M.L.A.; NIJENHUIS, L.E.; VAN ROOD, J.J. HLA-linked genetic control of host
response to Mycobacterium leprae. Lancet, 2:1328-1330, 1976.
20 FAYE, I.; RUSHER, H.; TSALA, M.P.; BLOC, G. Lèpre at groupe sanguin à Dakar. Bull. Soc. Med. Afr. Noire Langue Franc., 16(4) :551-553, 1971.
21 FREIRE-MAIA, D.V. Comportamento in vitro dos macrófagos humanos frente ao M. leprae. Estudo em pessoas sadias e pacientes com hanseníase virchoviana e tuberculóide. Hansen. Int., 8 (2) :81-90, 1983.
22 GOEDDE, H.W.; BENKMANN, H.G.; HIRTH, L.; ROHDE, R.; ROUGEMONT, A.; DELBRUCK, H. Phenotypes
of Gc and Tf in leprosy patients of Mali and Ethiopia. Hum. Hered., 24:383-386, 1975.
23 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15: 48-64, 1947.
24 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15(1) :31-47, 1947.
25 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr., 15(1) :21-30,
1947.
26 LANGUILLON, J.; LINHARD, J.; DIEBOLT, G. Groupes sanguins: hémoglobines anormales et lèpre. Bull.
Soc. Med. Afr. Noire Langue Franc., 16(4) :581-584, 1971.
27 LECHAT, M.F.; BIAS, W.B.; GUINTO, R.S.; COHEN, B.H.; TOLENTINO, J.G.; ABALOS, R.M. A study of various blood group systems in leprosy patients and controls in Cebu, Philippines. Int. J. Lepr., 36(1) : 17-31, 1968.
28 MORTON, N.E.; LEW, R.; HUSSELS, I.E.; LITTLE, G.F. Pingelap and Mokie Atolls: historical genetics. Amer. J. Hum.-Genet., 24:277-289, 1972.
29 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1):14-24, 1973.
30 REA, T.H. & TERESAK, P.I. HLA-DR antigens in tuberculoid and lepromatous leprosy. Lepr. Rev., 51(2) :117-123, 1980.
31 ROTBERG, A. Some aspects of immunity in leprosy and their importance in epidemiology, pathogenesis and
classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Bras. Leprol., 5(n. esp.) :45-97,
1937.
32 SALZANO, F.M.; SURE, M.V.; FERLAUTO, M. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17:530-544, 1967.
33 SCHWANTES, A.R.; SALZANO, F.M.; CASTRO, I.V.; TONDO, C.V. Haptoglobins and leprosy. Acta Genet. (Basel), 17:127-136, 1967.
34 SERJEANTSON, S.; WILSON, S.R.; KEATS, B.J.B. The genetics of leprosy. Ann. Hum. Biol., 6:375-393, 1979.
35 SMITH, D.G. The genetics hypothesis for susceptibility to lepromatous leprosy. Hum. Genet., 50(2) :163-177, 1979.
36 SPICKETT, S.G. Genetics and the epidemiology of leprosy. I. The incidence of leprosy. Lepr. Rev., 33(2):76-93,
1962.
37 SPICKETT, S.G. Genetics and the epidemiology of leprosy. II. The form of leprosy. Lepr. Rev., 34(3) :173-181,
1962.
38 SPIELMANN, W.; TEIXIDOR, D.; RENNINGER, W.; MATZNETTER, T. Blutgruppen and Lepra bei Moçambiquanischen Volkerschaften. Human genetik, 10(4):304-317, 1970.
39 VOGEL, T. ABO blood groups and leprosy. J. Med. Genet., 5:56-57, 1968.
40 WAL TER, H. ; BAJATZADEH, M. ; KELLERMANN, G. ; MATZNETTER, T. Associations between leprosy and serum protein groups. Humangenetik, 10:298-303, 1970.
41 YOUNGCHAIYUD, U. ; CHANDANAYINGYONG, D.; VIBHATAVAN IJA, T. The incidence of HLA antigens in leprosy. Vox Sang., 32(6):342-345, 1977.
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