Sistema sangüíneo Lewis em pacientes hansenianos

Eliane Aparecida Silva; Eliana Milanesi Rúbio; Somei Ura

doi:10.47878/hi.2000.v25.36433

Authors

Eliane Aparecida Silva Pesquisadora Cientifica, Equipe Técnica de Imunologia, Instituto "Lauro de Souza Lima", Bauru-SP.
Eliana Milanesi Rúbio Professora Doutora, Departamento de Urologia, Faculdade de Medicina, UNESP/Botucatu-SP.
Somei Ura Pesquisador Científico, Equipe Técnica de Clinica Médica, Instituto "Lauro de Souza Lima", Bauru-SP.

DOI:

https://doi.org/10.47878/hi.2000.v25.36433

Keywords:

Mycobacterium leprae, Lewis phenotype, Secretor phenotype, Blood group, Leprosy

Abstract

The distribution of Lewis blood group phenotypes in the saliva and on the erythrocytes of leprosy patients were evaluated, Forty seven patients and forty controls were analyzed by means of an agglutination and agglutination inhibition test for the presence of ABH and Lewis antigens on erythrocytes and in the saliva, The frequency of the Lewis phenotypes and secretor and non-secretor phenotypes were determined among the patients and in the control group. The results were: Le(a- b+) =29,8% (62,5%); Le(a+ b-) = 25,5% (7,5%); Le(a- b-) = 44,7% (30,0%); secretor = 59,5% (85%) and non secretor = 40,5% (15%) respectively. Statistical analysis using the X2 test showed significant difference between patients and controls concerning the Lewis phenotype (x2 = 10,46; D,F. = 2; p= 0,005) and secretor phenotype (x2 = 5,64; D.F. = 1; p = 0,018), Using the Z test
significant differences were found concerning the phenotypes Le (a+ b-) and Le (a- b+) (Z = 2,219; p = 0,027 and Z = 3,058; p = 0,002). The results
indicate that phenotype Le (a+ b-) is associated with susceptibility to leprosy and secretor phenotype with protection. It is speculated that the presence of Leb' in the saliva inhibits the adherence of M, leprae to the mucosa cells thus protecting against infection.

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References

1. ALY, F.Z.M. Oral yeast infection among patients with diabetes melitus. Edinburgh: University of Edinburgh 1992, Tese (Doutorado)
2. ANDRESEN, P. H. The blood group system L. A new blood group L2. A case of epistasy within the blood groups, Acta path. Microbial. Scand., v.25, p 728-731, 1948.
3. BEIGUELMAN, B. Sistema ABO e epidemiologia de lepra. Rev. paul. med., v.65, n.2; p,80-86, 1964.
4. BEIGUELMAN, B, Leprosy and genetics - review. Braz. J. genet., v,6, n.1, p,109-172, 1983.
6. BETH VINCENT, Técnicas aplicadas à imuno-hematologia eritrocitária. In, Alves de Lima, L., Callado,M, R, L., Santos, J, A, Curso de Imuno-ematologia. Botucatu. Faculdade de Medicina, p. 122, 1992.
8. BLACKWELL, C.C. Genetic susceptibility to infections agents, Proc. Proy. Coll. Phys. (Edinburgh), v19, p.129-138, 1989.
7,CHAIN, W, FOXMAN, B., SOHEL, JD, Association of recurrent vaginal candidiasis and secretory ABO and Lewis phenotype. J. Infect Dis., v,17; n.3, p,828-30, 1997,
8. CONGRESSO NACIONAL DE LEPROLOGIA 6s, Madrid, 1953. Memória. Madrid, Association International de Lepra, 1953. 1344p.
9. CRITCHLEY, I, A. AND DOUGLAS, L.J, Role of glycosides as epithelial cell receptors for Candida albicans. J. Gen. Microbial., v.133, p.637-643, 1987
10, DUNSFORD, I., BOWLEY, C,C, apud SALDANHA, S,G, ABO blood groups and salivary secretion of ABH substances among three racial groups in São Paulo, Rev. Brasil. Genet., v,1, p.175-186, 1982,
11. ELLISON, R.C,, ZHANG, Y., MYERS, R,H,, SWANSON, J.L,, HIGGINS, M., ECKFELDT, J, Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI family heart study). Am. J. Cardiol; v,83; n.3; p,345-8, 1999.
13. FEITOSA, M.F. , KRIEGER, H, , BEIGUELMAN, B. Epidemiologia genética da hanseníase e da reação de Mitsuda, Hans. Internat., v.20; n,2, p,5-8, 1995,
15. GAFFNEY, R,A,, SHAEFFER, A.J., DUNCAN, J,L. Lewis blood group antigen expression by cultured normal uretral epithelial cells, J. Urology, v.148, p,1341-46, 1992
16. GIBBONS, R,J,, QURESHI, J,V. Selective binding of blood group-reactive salivary mucins by Streptococcus mutans and other oral organisms, Infect. Immun., v.22, p.665-671, 1978.
17. HENRY, S., ORIOL, R., SAMUELSSON, Bo, Lewis histo-blood group system and associated secretory phenotypes - Review. lox Sang, v.69, p.166-182, 1995.
18. JACOBSON, S.H,, LOMBERG, H. Over-representation of blood group non-secretors in adults with renal scarring, Scand. J. UroL Nephrol., v,24, p.145-150, 1990.
19. KABAYASHI, C., SAKAMOTO, J. KITO, T,, YAMAMURA, Y,, KASHIKAVA, T., FUJITA, M,, WATANABE, T,, NAKAZATO, H,, Lewis blood group — related antigen expression in normal gastric epithelium, intestinal metaplasia, gastric adenoma and gastric carcinoma, Am. J. Gastroenterology, v,88; n.6, p.919-924, 1993
20. KALLENIUS, G,, SVENSON, S,B,, MÖLLBY, R., CEDERGREN, B., HULTBERG, H., WINBERG, J, Structure of carbohidrate part of receptor on human uroepi thel ial cel ls for pyelonephritogenic Escherichia colt. Lancet. v.2, p.604-606, 1981.
19.KAUFFMANN, F., FRETTE, C,, PHAM, Q,T., NAFISSI, S,, BERTRAND, J.P., ORIOL, R. Associations of blood grouprelated antigens to FEV1, wheezing and asthma, Am. J. Resp Crit Cure Med., v.153,, p.76-82, 1996
20.LEE, C, H,,HAGEN, M. A,, CHONG, B. H,, GRACE, C. S. ROZEMBERG, M, C,The Lewis system and secretor status in autoimmune hemolytic anemia complicating infectious mononucleosis. Transfusion, v,20; n.3, p,585-588, 1980.
21.MOLLISON, P.L, Blood transfusion in clinical medicine, Oxford, Blackwell Scientific Publications, 1979,
22.MOURANT, A,E, A "new" human blood group antigen of frequent occurrence, Nature, Lond, v,158, p.237, 1946,
23.MOURANT, A.E., KOPEC, A,C,, DOMAMIEWSKA-SOBEZA, K, Oxiford University Press, The blood groups and other polymorphic systems, 1978.
24.ROBINSON, C.B., MARTIN, W,R., RATLIFF, J,L., HOLLAND, P.V., WU, R,, CROSS, C. E. Elevated levels of serum mucinassociated antigen in adult patients with cystic fibrosis, Am. Rev. Respir. Dis. v.148, p,385-89, 1993,
25.RUIZ, B., CORREA, P., FONTHAM, E.T,H,, ROOD, J. C, M A L C O M , G , T , , T O R R A D O , J , , P E R E Z , A . , RAMAKRISHNAN, T,, HUNTER, F. M, Ascorbic acid, Helicobacter pylori and Lewis phenotype among blacks and whites in New Orleans, Cancer Letters, v,83, p,323-29, 1994.
26.SHEINFELD, J,, SCHAEFFER, A,J., CORDONCARDO, C., ROGATKO, A., FAIR, W.R, Association of the Lewis-blood phenotype with recurrent urinary tract infections in women. N. Engl. J. Med., v,320, p,773-777, 1989,
27.SPIELMANN, W,, TEIXIDOR, D., RENNINGER, W, MATZNETTRE, T, Blutgruppen und Lepra bei moçambiquanischen Võlkerschaften, Hummangenetik,
v.10, p.304-317, 1970.
28.WIENER, A.S, Blood groups and disease, Lancet., v,1., p,813-816, 1962.