Palabras clave
Hanseníase
Complexos Imunes C1q
Complexos Imunes C1q
Cómo citar
1.
KLEEMANN TAE, FERRI RG, CHAVES J, IRULEGUI I, COPPI VAZ CA. Detecção de complexos imunes circulantes na hanseníase utilizando C1q humano e eqüino. Hansen. Int. [Internet]. 30 de noviembre de 1978 [citado 3 de agosto de 2025];3(2):135-40. Disponible en: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36079
Resumen
Observou-se a presença de complexos imunes circulantes (IC) em soros de pacientes de hanseníase virchowiana com e sem eritema nodoso. Estes IC foram detectados por sua reação com o componente CA do complemento, após prévia concentração dos IC por poletileno-glicol (PEG) e solubilização em tampão borato. A presença dos IC foi confirmada por redução e alquilação dos IC seguida de nova difusão contra C,q.
Citas
1. AGNELLO, V.; GABRIEL JR, A.; MINDY TAI, B.A. Detection of immune complexes. J. Invest. Derm., 67(3) :339-345, 1976.
2. AGNELLO, V.; WINCHESTER, R.J.; KUNKEL, H.G. Precipitin reactions of the Clq component of complement with aggregated gamma-globulin and immune complexes in gel diffusion. Immunology, 19:909-919, 1970.
3. BONOMO, L. & DAMMACCO, F. Immune complex cryoglobulinaemia in lepromatous leprosy: a pathogenetic approach to some clinical features of leprosy. Clin. Exp. Immunol., 9:175-181, 1971.
4. BOUT, D.; SANTORO, F.; CARLIER, Y.; CAPRON, A. Imuno-complexos na esquistossomose. III. Caracterização das imunoglobulinas e dos antígenos implicados no IC. Rev. Inst. Med. Trop. São Paulo, 19(1) :35-38, 1977.
5. CHAVES, J.; FERRI, R.G.; KLIEMANN, T.A.E.; IRULEGUI, I. Complexos imunes circulantes na doença de Chagas experimental. Identificação de antígenos parasitários nos complexos. [No prelo]
6. EWALD, R.W. & SCHUBART, A.F. Agglutinating activity of the complement component C',q in the F-II latex fixation test. J. Immunol., 97(1):100-106, 1966.
7. GELBER, R.H.; EPSTEIN, W.V.; FASAL, P.; DRUTZ, D.J. Detection of circulating immune complex-like activity in the sera of patients with erythema nodosum leprosum. In: LEPROSY RESEARCH CONFERENCE, 7th, Menlo Park Ca., 1972. Program apud Int. J. Lepr., 40(2):218-219, 1972.
8. JUNQUEIRA, L.C.; BIGNOLAS, G.; FERRI, R.G.; CHAVES, J.; KLIEMANN, T.A.E. Staining of Clq protein from human and horse complement with dye Sirius Red. [No prelo]
9. MORAN, C.J.; RYDER, G.; TURK, J.L.; WATERS, M.F.R. Evidence for circulating immune complexes in lepromatous leprosy. Lancet, 2(7777): 572-573, 1972.
10. MULLER EBERHARD, H.J. & KUNKEL, H.G. Isolation of a thermolabile serum protein which precipitates gamma-globulin aggregates and participates in immune hemolysis. Proc. Soc. Exp. Biol, Med., 106(2):291-295, 1961.
11. ROJAS-ESPINOSA, O.; MENDEZ- NAVARRETE, I.; ESTRADA-PARRA, S. Presence of Clq-reactive immune complexes in patients with leprosy. Clin. Exp. Immunol., 12:215-223, 1972.
12. WEMAMBU, S.N.C.; TURK, T.L.; WATERS, M.F.R., REES, R.J.W. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933-935, 1969.
13. WINCHESTER, R.J. & AGNELLO, V. Detection of immune complexes by direct precipitation with C,q or IBM rheumatoid factors. Ann. Rheum. Dis., 36(suppl.) :35-36. 1977.
14. ZUBLER, R.H.; PERRIN, L:H.; CREIGHTON, W.D.; LAMBERT, P.H. Use of polyethilene glycol (PEG) to concentrate immune complexes from serum or plasma samples. Ann. Rheum. Dis., 36(suppl.) :23-25, 1977.
2. AGNELLO, V.; WINCHESTER, R.J.; KUNKEL, H.G. Precipitin reactions of the Clq component of complement with aggregated gamma-globulin and immune complexes in gel diffusion. Immunology, 19:909-919, 1970.
3. BONOMO, L. & DAMMACCO, F. Immune complex cryoglobulinaemia in lepromatous leprosy: a pathogenetic approach to some clinical features of leprosy. Clin. Exp. Immunol., 9:175-181, 1971.
4. BOUT, D.; SANTORO, F.; CARLIER, Y.; CAPRON, A. Imuno-complexos na esquistossomose. III. Caracterização das imunoglobulinas e dos antígenos implicados no IC. Rev. Inst. Med. Trop. São Paulo, 19(1) :35-38, 1977.
5. CHAVES, J.; FERRI, R.G.; KLIEMANN, T.A.E.; IRULEGUI, I. Complexos imunes circulantes na doença de Chagas experimental. Identificação de antígenos parasitários nos complexos. [No prelo]
6. EWALD, R.W. & SCHUBART, A.F. Agglutinating activity of the complement component C',q in the F-II latex fixation test. J. Immunol., 97(1):100-106, 1966.
7. GELBER, R.H.; EPSTEIN, W.V.; FASAL, P.; DRUTZ, D.J. Detection of circulating immune complex-like activity in the sera of patients with erythema nodosum leprosum. In: LEPROSY RESEARCH CONFERENCE, 7th, Menlo Park Ca., 1972. Program apud Int. J. Lepr., 40(2):218-219, 1972.
8. JUNQUEIRA, L.C.; BIGNOLAS, G.; FERRI, R.G.; CHAVES, J.; KLIEMANN, T.A.E. Staining of Clq protein from human and horse complement with dye Sirius Red. [No prelo]
9. MORAN, C.J.; RYDER, G.; TURK, J.L.; WATERS, M.F.R. Evidence for circulating immune complexes in lepromatous leprosy. Lancet, 2(7777): 572-573, 1972.
10. MULLER EBERHARD, H.J. & KUNKEL, H.G. Isolation of a thermolabile serum protein which precipitates gamma-globulin aggregates and participates in immune hemolysis. Proc. Soc. Exp. Biol, Med., 106(2):291-295, 1961.
11. ROJAS-ESPINOSA, O.; MENDEZ- NAVARRETE, I.; ESTRADA-PARRA, S. Presence of Clq-reactive immune complexes in patients with leprosy. Clin. Exp. Immunol., 12:215-223, 1972.
12. WEMAMBU, S.N.C.; TURK, T.L.; WATERS, M.F.R., REES, R.J.W. Erythema nodosum leprosum: a clinical manifestation of the Arthus phenomenon. Lancet, 2:933-935, 1969.
13. WINCHESTER, R.J. & AGNELLO, V. Detection of immune complexes by direct precipitation with C,q or IBM rheumatoid factors. Ann. Rheum. Dis., 36(suppl.) :35-36. 1977.
14. ZUBLER, R.H.; PERRIN, L:H.; CREIGHTON, W.D.; LAMBERT, P.H. Use of polyethilene glycol (PEG) to concentrate immune complexes from serum or plasma samples. Ann. Rheum. Dis., 36(suppl.) :23-25, 1977.
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