Keywords
Hanseniasis
Macrophage
Mycobacterium leprae
Macrophage
Mycobacterium leprae
How to Cite
1.
Freire-Mata DV. Comportamento in vitro frente ao Mycobacterium leprae dos macrófagos de pessoas sadias e de pacientes com hanseníase. Hansen. Int. [Internet]. 1983 Nov. 30 [cited 2024 Nov. 23];8(2):81-90. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36133
Abstract
The in vitro phagocytic capacity of human macrophages facing M. leprae was analysed in a selected sample of healthy and hanseniasis patients (Vircho-wian and tuberculoid) individuals. Families where at least one of the spouses presented Hansen's disease were selected and 176 white people were studied. The analysis of the macrophages' behavior was performed by reading the slides in the 5th, 10th, 15th, 20th and 30th days after inoculation of M. leprae. The classification is discussed. The results showed a high variability. The main
conclusions reached are: (a) people differ in their capacity to lyse M. leprae, as measured by their macrophages' behavior in vitro; (b) the results obtained give support to Beiguelman's theory of the lysis threshold.
References
1 BECHELLI, L.M.; SOUZA, P.R.; QUAGLIATO, R. Correlação entre os resultados da leitura clínica e do exame
histopatológico da reação de Mitsuda. Rev. Bras. Leprol., 27(4) :172-182, 1959.
2 BEIGUELMAN, B. Fur the r re sul ts on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF HUMAN GENETICS, 3, Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.3 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência à lepra. Cien. Cult., 17(4) :449-460, 1965.
4 BEIGUELMAN, B. The genet ics of resistance to leprosy. Int. J. Lepr., 33(4) :808-812, 1965.
5 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
6 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese-Faculdade de Medicina de Ribeirão
Preto].
7 BEIGUELMAN, B. Lepra e Genética. Cien. Cult., 34:1121-1146, 1982.
8 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin analysis. Acta Leprol. (44) :5-65, 1971.
9 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., /7(4):
584-594, 1968.
10 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
11 BENEWOLENSKAJA, S.W. Uber die in-vitro - Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
12 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp. Immunol., 36(2) :214-220, 1979.
13 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
14 FREIRE-MAIA, D.V. Análise familial do comportamento "in-vitro" dos macrófagos humanos frente ao Mycobacterium leprae. São Paulo, 1972. 142p [Tese-Faculdade de Medicina da UNICAMP].
15 GODAL, T.; MYRVANG, B. ; STANFORD, J.L.; SAMUE, D.R. Recent advances in the immunology of leprosy
with special reference to new approaches in immunoprophylaxis. Hanseníase, 7(1/2):7-31, 1976.
16 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15(1) :
48-64, 1947.
17 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15 (1) :31-47, 1947.
18 HANKS, J.H. Microscopic counts of Mycobacteria conversion factors for the pinhead method. Int. J. Lepr., 36(1) : 76-77, 1968.
19 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr.. 15(1) :21-30,
1947.
20 HANKS, J.H.; CHATTERJEE, B.R.; LECHAT, M.F. A guide to the counting of Mycobacteria in clinical
and experimental materials. Int. J. Lepr., 32(2) :156-167, 1964.
21 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1) :14-24, 1973.
22 REA, T. & LEVAN, N.E. Current concepts in the immunology of leprosy. Hanseniase, 9(1/2):13-25, 1978.
23 RIDLEY, D.S. Review of the five-group system for the classification of leprosy according to immunity. bit. J.
Lepr., 40 (1) :102-103, 1972.
24 RIDLEY, D.S. & JOPLING, W.H. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr., 34(3):255-273, 1966.
25 RIDLEY, D.S. & WATERS, M.F.R. Significance of variations within the lepromatous group. Lepr. Rev., 40 (3) :143-152, 1969.
histopatológico da reação de Mitsuda. Rev. Bras. Leprol., 27(4) :172-182, 1959.
2 BEIGUELMAN, B. Fur the r re sul ts on the genetics of leprosy resistance. In: INTERNATIONAL CONGRESS OF HUMAN GENETICS, 3, Chicago, 1966. Abstracts of Contributed Papers. Chicago, 1966. p.6-7.3 BEIGUELMAN, B. Genética e epidemiologia das doenças transmissíveis com especial referência à lepra. Cien. Cult., 17(4) :449-460, 1965.
4 BEIGUELMAN, B. The genet ics of resistance to leprosy. Int. J. Lepr., 33(4) :808-812, 1965.
5 BEIGUELMAN, B. Hereditariedade da reação de Mitsuda. Rev. Bras. Leprol., 30(4) :153-172, 1962.
6 BEIGUELMAN, B. Hereditariedade e lepra. São Paulo, 1969. n.p. [Tese-Faculdade de Medicina de Ribeirão
Preto].
7 BEIGUELMAN, B. Lepra e Genética. Cien. Cult., 34:1121-1146, 1982.
8 BEIGUELMAN, B. Lepromin reaction: genetics studies including twin analysis. Acta Leprol. (44) :5-65, 1971.
9 BEIGUELMAN, B. Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol., /7(4):
584-594, 1968.
10 BEIGUELMAN, B. & QUAGLIATO, R. Nature and familial character of the lepromin reactions. Int. J. Lepr., 33
(4) :800-807, 1965.
11 BENEWOLENSKAJA, S.W. Uber die in-vitro - Reaktion der embryonalen Gewebe and Leukocyten des Menschen auf Leprabacillen. Arch. Exper. Zellforsch., 13:37-46, 1932.
12 CONVIT, J.; ARANZAZU, N.; PINARDI, M.; ULRICH, M. Immunological changes observed in determinate and
lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp. Immunol., 36(2) :214-220, 1979.
13 DELVILLE, J. In vitro behavior of macrophages from healthy persons against M. leprae and other mycobacteria. Int. J. Lepr., 39:329-339, 1971.
14 FREIRE-MAIA, D.V. Análise familial do comportamento "in-vitro" dos macrófagos humanos frente ao Mycobacterium leprae. São Paulo, 1972. 142p [Tese-Faculdade de Medicina da UNICAMP].
15 GODAL, T.; MYRVANG, B. ; STANFORD, J.L.; SAMUE, D.R. Recent advances in the immunology of leprosy
with special reference to new approaches in immunoprophylaxis. Hanseníase, 7(1/2):7-31, 1976.
16 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from lepromatous lesions. Int. J. Lepr., 15(1) :
48-64, 1947.
17 HANKS, J.H. The fate of leprosy bacilli in fibroblasts cultivated from macular and tuberculoid lesions. Int. J.
Lepr., 15 (1) :31-47, 1947.
18 HANKS, J.H. Microscopic counts of Mycobacteria conversion factors for the pinhead method. Int. J. Lepr., 36(1) : 76-77, 1968.
19 HANKS, J.H. A study of the bacilli in tissue cultures of lepromata in serum media. Int. J. Lepr.. 15(1) :21-30,
1947.
20 HANKS, J.H.; CHATTERJEE, B.R.; LECHAT, M.F. A guide to the counting of Mycobacteria in clinical
and experimental materials. Int. J. Lepr., 32(2) :156-167, 1964.
21 PISANI, R.C.B.; BEIGUELMAN, B.; OPROMOLLA, D.V.A. In vitro behavior of blood derived macrophages
against killed M. leprae. Int. J. Lepr., 41(1) :14-24, 1973.
22 REA, T. & LEVAN, N.E. Current concepts in the immunology of leprosy. Hanseniase, 9(1/2):13-25, 1978.
23 RIDLEY, D.S. Review of the five-group system for the classification of leprosy according to immunity. bit. J.
Lepr., 40 (1) :102-103, 1972.
24 RIDLEY, D.S. & JOPLING, W.H. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr., 34(3):255-273, 1966.
25 RIDLEY, D.S. & WATERS, M.F.R. Significance of variations within the lepromatous group. Lepr. Rev., 40 (3) :143-152, 1969.
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