Type I reaction in lepromatous patients ten years after cure

Authors

  • Somei Ural Médico dermatologista e Pesquisador cientifico - Instituto Lauro de Souza Lima - Secretaria de Estado da Saúde - Bauru - SP
  • Diltor Vladimir Araujo Opromolla Medico dermatologista e Diretor da Divisão de Pesquisa e Ensino - Instituto Lauro de Souza Lima - Secretaria de Estado da Saúde.
  • Deise Aparecida dos Santos Codoy Médica dermatologista - Instituto Lauro de Souza Lima - Secretaria de Estado da Saúde.
  • Raul Negrão Fleury Médico anátomo patologista e pesquisador cientifico - Instituto Lauro de Souza Lima - Secretaria de Estado da Saúde.

DOI:

https://doi.org/10.47878/hi.2001.v26.36406

Keywords:

Lepromatous leprosy, borderline leprosy, type I reaction, immunotherapy

Abstract

A case of lepromatous leprosy patient treated with rifampin and dapsone for six months, and then treated with dapsone only for 14 years, is presented. The patient remained without lesions and with negative bacilloscopy for 10 years, and after this period he started again to show lesions, now with borderline aspect and appearance of bacilli. The authors suggest that the patient has always been a borderline whose disease has become more severe to the point that he presented a lepromatous aspect. When bacilli started to show up again, the patient's cellular immunity destroyed them so that borderline lesions appeared, as it must have happened in the initial phase of the disease. They also discuss the possible causes that led bacilli, probably persistent, to multiply again.

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References

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3 OPROMOLLA, D. V. A. et al. A controlled trial to compare the therapeutic effects of Dapsone in combination with daily or once- monthly rifampicin in patients with lepromatous leprosy. Int J. Leprosy, v.49, n.4, p.393-397, 1981.
4 WORLD HEALTH ORGANIZATION. Subcommittee on clinical trials of the chemotherapy of leprosy (THELEP) scientific working group of the UNDP/Word bank / WHO Special Programme for the research and training in tropical disemPq. Persisting Mycobacterium leprae among THELEP trials patients in Bamako and Chingleput. Leprosy Rev., v.58, p.325-337, 1987.
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Published

2001-11-30

How to Cite

1.
Ural S, Opromolla DVA, Codoy DA dos S, Fleury RN. Type I reaction in lepromatous patients ten years after cure. Hansen. Int. [Internet]. 2001 Nov. 30 [cited 2024 May 13];26(2):117-20. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36406

Issue

Section

Estudos clínicos

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